Thiopurine S-Methyltransferase Polymorphisms Predict Hepatotoxicity in Azathioprine-Treated Patients with Autoimmune Diseases. [PDF]
J Pers Med, 2022 Sheu HS +8 more
europepmc +1 more source
Molybdenum Cofactor Catabolism Unravels the Physiological Role of the Drug Metabolizing Enzyme Thiopurine S-Methyltransferase. [PDF]
Clin Pharmacol Ther, 2022 Pristup J +15 more
europepmc +1 more source
Therapeutic decision making in autoimmune and inflammatory disorders of the central nervous system in children. [PDF]
, 2016 Autoimmune and inflammatory disorders of the central nervous system can result in significant morbidity and mortality. Through the recognition of syndromes using diagnostic biomarkers, the clinician is now able to use immune suppressive therapies to ...
Dale, Rc, Lim, M., Nosadini, M
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A phase II clinical trial of 6-mercaptopurine (6MP) and methotrexate in patients with BRCA defective tumours: a study protocol [PDF]
, 2014 BACKGROUND: BRCA1 and BRCA2 genes are critical in homologous recombination DNA repair and have been implicated in familial breast and ovarian cancer tumorigenesis. Tumour cells with these mutations demonstrate increased sensitivity to cisplatin and poly (
+11 more
core +2 more sources
Acta Medica Iranica, 2017 Thiopurine drugs remain pivotal therapies for the wide varieties of diseases such as inflammatory bowel disease (IBD). Here, thiopurine S-methyltransferase (TPMT) phenotype, the main metabolizing enzyme of thiopurine-drugs, was studied.
Fariborz Bahrehmand +6 more
doaj
Indian Journal of Rheumatology, 2019 Azathioprine, an analog of mercaptopurine, is used for various inflammatory/autoimmune diseases in diverse fields such as rheumatology, ophthalmology, gastroenterology, and neurology.
Debashish Mishra +4 more
doaj +1 more source
Rifampin modulation of xeno- and endobiotic conjugating enzyme mRNA expression and associated microRNAs in human hepatocytes [PDF]
, 2018 Rifampin is a pleiotropic inducer of multiple drug metabolizing enzymes and transporters. This work utilized a global approach to evaluate rifampin effects on conjugating enzyme gene expression with relevance to human xeno- and endo-biotic metabolism ...
Desta, Zeruesenay +7 more
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Current Status of Autoimmune Hepatitis in Japan [PDF]
, 2008 Autoimmune hepatitis (AIH) is a chronic and progressive disease characterized by histological interface hepatitis, hypergammaglobulinemia, and circulating autoantibodies. Multiple factors, including molecular mimicry, a genetic background including major
Miyake, Yasuhiro, Yamamoto, Kazuhide
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Pharmacogenomics and Personalized Medicine, 2020 Changhee Ha,1 Eun Sil Kim,2 Yiyoung Kwon,2 Yon Ho Choe,2 Mi Jin Kim,2 Soo-Youn Lee1,3 1Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; 2Department of Pediatrics, Samsung ...
Ha C +5 more
doaj
Bone marrow inhibition induced by azathioprine in a patient without mutation in the thiopurine S-methyltransferase pathogenic site: A case report. [PDF]
World J Clin Cases, 2021 Zhou XS, Lu YY, Gao YF, Shao W, Yao J.
europepmc +1 more source