Results 111 to 120 of about 5,310 (212)

TPMT Genetic Variability and Its Association with Hematotoxicity in Indonesian Children with Acute Lymphoblastic Leukemia in Maintenance Therapy

Pharmacogenomics and Personalized Medicine, 2021
Dewi Selvina Rosdiana,1 Rianto Setiabudy,1 Rizka Andalusia,2,3 Djajadiman Gatot,4 Melva Louisa,1 Saptawati Bardosono,5 Instiaty Instiaty1 1Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia ...
Rosdiana DS, Setiabudy R, Andalusia R, Gatot D, Louisa M, Bardosono S, Instiaty I   +6 more
doaj  

Enhanced specificity of TPMT*2 genotyping using unidirectional wild-type and mutant allele-specific scorpion primers in a single tube.

PLoS ONE, 2014
Genotyping of thiopurine S-methyltransferase (TPMT) is recommended for predicting the adverse drug response of thiopurines. In the current study, a novel version of allele-specific PCR (AS-PCR), termed competitive real-time fluorescent AS-PCR (CRAS-PCR ...
Dong Chen, Zhao Yang, Han Xia, Jun-Fu Huang, Yang Zhang, Tian-Nun Jiang, Gui-Yu Wang, Zheng-Ran Chuai, Wei-Ling Fu, Qing Huang   +9 more
doaj   +1 more source

Relationship Between Thiopurine S-Methyltransferase Genotype/Phenotype and 6-Thioguanine Nucleotide Levels in 316 Patients With Inflammatory Bowel Disease on 6-Thioguanine. [PDF]

Ther Drug Monit, 2021
Bayoumy AB, Mulder CJJ, Loganayagam A, Sanderson JD, Anderson S, Boekema PJ, Derijks LJJ, Ansari AR.   +7 more
europepmc   +1 more source

Sequential group trial to determine gastrointestinal site of absorption and systemic exposure of azathioprine [PDF]

, 2000
Azathioprine (AZA) is used in the treatment of patients with refractory inflammatory bowel disease; however, its use is limited because of systemic toxicity associated with long-term use.
Abell, Thomas, Brown, Rex O., Gervasio, Jane M., Haberer, Lynda J., Hak, Lawrence J., Lima, John, Tabbaa, M. G., Werkman, Robert   +7 more
core   +1 more source

Scorpion primer PCR analysis for genotyping of allele variants of thiopurine s‑methyltransferase*3. [PDF]

Mol Med Rep, 2020
Yao P, Qu XM, Ren S, Ren XD, Su N, Zhao N, Wang L, Cheng L, Weng BB, Sun FJ, Huang Q.   +10 more
europepmc   +1 more source

Identifikasi Gen Selenometil Transferase (Smt) Pada Isolat Geobacillus SP. 20k Yang Resisten Terhadap Selenium [Identification of Seleno Methyltransferase {Smt) Gene From Geobacillus SP. 20k Resistant to Selenium] [PDF]

, 2010
The trace element Selenium is toxic at high concentration.Most of organisms living in selenium rich environment are selenium resistant.One of the resistance mechanisms is methylation,in which selenium is methylated and transformed to non-toxic selenium ...
Dewi, R. M. (Ratih), Kasim, E. (Ernawati), Nurhidayat, N. (Novik), Triana, E. (Evi), Yulinery, T. (Titin)   +4 more
core  

The Identification of a Novel Thiopurine S-Methyltransferase Allele, TPMT*45, in Korean Patient with Crohn's Disease. [PDF]

Pharmgenomics Pers Med, 2020
Ha C, Kim ES, Kwon Y, Choe YH, Kim MJ, Lee SY.   +5 more
europepmc   +1 more source

Personalised medicine, unmet need or business strategy?

, 2013
Personalised medicine is a discipline that integrates pharmaceutical development with existing knowledge about the genetic and phenotypic factors that influence drug response.
Sáinz de la Fuente, G. (Graciela)
core  

Thiopurine S-Methyltransferase Assay by HPLC in Acute Lymphoblastic Leukemia Patients and a Healthy Iranian Population

Acta Medica Iranica, 2018
Thiopurine s-methyltransferase (TPMT) plays a key role in the metabolism of the drug; 6-MP in children with acute lymphoblastic leukemia (ALL). The wild-type TPMT*1 allele and mutant alleles are associated with normal and intermediate enzyme activity ...
Sima Mozafari, Nahid Einollahi, Elham Shahgholi, Safoura Vardasbi, Abolfazl Golestani   +4 more
doaj  

UEG Week 2025 Moderated Posters

United European Gastroenterology Journal, Volume 13, Issue S8, Page S189-S802, October 2025.
wiley   +1 more source