Drug Development Research, Volume 87, Issue 4, June 2026.ABSTRACT Santamarine (SAMA), a Michelia compressa‐derived sesquiterpene lactone, exhibits ROS‑mediated anticancer activity; however, its potential mechanisms and synergy with cisplatin in oral cancer have not been explored. This study investigated SAMA and cisplatin's combined effects and underlying ROS/MAPK mechanisms of action on oral cancer cells ...
Hsin‐I. Lu +8 more
wiley +1 more source
The Role of Peroxiredoxins in the Mechanisms of Oxidative Stress in Patients After Aneurysmal Subarachnoid Hemorrhage. [PDF]
Int J Mol SciZaczkowski K +8 more
europepmc +1 more source
Multi‐Omics Analyses Elucidate the Venom Components of the Wasp Vespa mandarinia
Ecology and Evolution, Volume 16, Issue 6, June 2026.The wasp Vespa mandarinia was widely reared in Yunnan province. The venom was responsible for their aggressive behavior. Tweety proteases, hyaluronidase, venom dipeptidyl peptidase 4, and phospholipase A1 and A2 isozyme were identified. In addition, organic heterocyclic compounds, organic acids, and derivatives were found.
Yuan‐Chong Shi +4 more
wiley +1 more source
MESH1-mediated coenzyme A degradation drives ferroptosis sensitivity and muscle pathology. [PDF]
J Clin InvestLin CC +22 more
europepmc +1 more source
Thioredoxin and its partner protein are essential for zoospore flagellar formation in Actinoplanes missouriensis. [PDF]
Commun BiolKimura T +4 more
europepmc +1 more source
TCM‐Guided Targeted Therapies Against NLRP3 Inflammasome in NAFLD
Immunity, Inflammation and Disease, Volume 14, Issue 6, June 2026.This graphical abstract illustrates TCM syndrome differentiation‐guided targeted strategies against NLRP3 inflammasome‐mediated non‐alcoholic fatty liver disease (NAFLD). Metabolic dysfunction and gut‐liver axis dysregulation drive NAFLD progression, activating the NLRP3 inflammasome (comprising NLRP3, ASC, caspase‐1) to trigger cytokine release (IL‐1β,
Yanxia Zhang
wiley +1 more source
Familial glucocorticoid deficiency due to a novel <i>TXNRD2</i> variant: expanding the spectrum of a rare genetic cause. [PDF]
Front Endocrinol (Lausanne)Al Alwan I +11 more
europepmc +1 more source
Vacuolization as a Novel Approach to Cancer Therapy
Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 6, June 2026.This review discusses the novel strategy of inducing vacuole formation in cancer cells using small molecules, that induce nonapoptotic cell death mechanisms, such as paraptosis, oncosis, autophagy, and methuosis, and its potential in overcoming resistance to apoptosis‐based cancer therapies.
Mariah Pasternak +9 more
wiley +1 more source
Unveiling the thioredoxin fold: a systematic review and bioinformatic analysis of protein disulfide isomerase and Dsb family proteins. [PDF]
Front BioinformCuevas Ortiz D +8 more
europepmc +1 more source
Dysregulation of Non‐Muscle Myosin IIA Assembly and Phosphorylation in S100A4 Null Mouse Lens
Journal of Cellular Physiology, Volume 241, Issue 6, June 2026.This study identifies S100A4 as a critical regulator of NMIIA assembly, phosphorylation, and actin cytoskeletal organization in the ocular lens. Loss of S100A4 disrupts lens fiber cell architecture and impairs lens transparency, revealing a previously unrecognized role for S100A4 in maintaining lens homeostasis and structural integrity.
Rupalatha Maddala +3 more
wiley +1 more source