Results 1 to 10 of about 8,679 (187)

Anticancer Activity and Safety Profile of Novel 1-(4-Fluorophenoxyacetyl)-4-substituted Thio/Semicarbazide Derivatives [PDF]

Molecules
Compounds with thiosemicarbazide and semicarbazide scaffolds are among the most promising structures in medicinal chemistry due to the possibility of forming multiple hydrogen bonds.
Paweł Kozyra, Ewelina Humeniuk, Zbigniew Karczmarzyk, Adrian Borzęcki, Grzegorz Adamczuk, Agnieszka Korga-Plewko, Waldemar Wysocki, Monika Pitucha   +7 more
doaj   +2 more sources

Synthesis of 1,2,4-Triazole-3-Thiol Derivatives from Thiosemicarbazides and Carboxylic Acids Using Polyphosphate Ester [PDF]

Molecules
Conditions have been established for the direct reaction of thiosemicarbazides with carboxylic acids in the presence of polyphosphate ester (PPE) to synthesize 1,2,4-triazole-3-thiol derivatives.
Bogdan A. Tretyakov, Viktoria I. Tikhonova, Svyatoslav Y. Gadomsky, Nataliya A. Sanina   +3 more
doaj   +2 more sources

Crystal structure of 2′-hydroxyacetophenone 4-methylthiosemicarbazide [PDF]

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the organic molecule of the title hydrate, C11H15N3OS·H2O, {systematic name: 3-ethyl-1-{(E)-[1-(2-hydroxyphenyl)ethylidene]amino}thiourea monohydrate}, a dihedral angle of 5.39 (2)° is formed between the hydroxybenzene ring and the non-H atoms ...
Junita Jamsari, Nur Fatihah Abas, Thahira Begum S. A. Ravoof, Edward R. T. Tiekink   +3 more
doaj   +3 more sources

Synthesis and Biological Evaluation of New Compounds with Nitroimidazole Moiety [PDF]

Molecules
Heterocyclic compounds, particularly those containing azole rings, have shown extensive biological activity, including anticancer, antibacterial, and antifungal properties.
Katarzyna Dziduch, Sara Janowska, Sylwia Andrzejczuk, Paulina Strzyga-Łach, Marta Struga, Marcin Feldo, Oleg Demchuk, Monika Wujec   +7 more
doaj   +2 more sources

New Thiosemicarbazide Derivatives with Multidirectional Biological Action. [PDF]

Molecules
Over the years, several new medicinal substances have been introduced for the treatment of diseases caused by bacteria and parasites. Unfortunately, due to the production of numerous defense mechanisms by microorganisms and parasites, they still pose a serious threat to humanity around the world.
Lasek P, Kosikowska U, Kołodziej P, Kubiak-Tomaszewska G, Krzyżanowska N, Szostek T, Struga M, Feldo M, Bogucka-Kocka A, Wujec M.   +9 more
europepmc   +5 more sources

Preparation of new Schiff bases based on thiosemicarbazide and evaluation of their inhibitory properties on corrosion of carbon steel in acidic environment [PDF]

شیمی کاربردی روز, 2023
In this work, two Schiff bases named 1-(2-hydroxybenzylidene)-4-phenylthiosemicarbazide (2-HTSC) and 1-(3-hydroxybenzylidene)-4-phenylthiosemicarbazide (3-HTSC) were synthesized and evaluated their inhibitory properties on corrosion of carbon steel in 15%
Homayoon Eslamizadeh, Asadollah Mohammadi, Somayeh Mohammadi   +2 more
doaj   +1 more source

Lipophilicity Studies on Thiosemicarbazide Derivatives [PDF]

Molecules, 2017
The lipophilicity of two series of thiosemicarbazide derivatives was assessed by the RP-HPLC method with the RP-18 chromatographic column and the methanol–water mixture as the mobile phase. Distribution coefficients logPHPLC were compared to calculated values generated by commonly used AClogP software and quantum chemical calculations.
Agata Paneth, Anna Hawrył, Tomasz Plech, Mirosław Hawrył, Ryszard Świeboda, Dominika Janowska, Monika Wujec, Piotr Paneth   +7 more
openaire   +4 more sources

Exploring Novel Pyridine Carboxamide Derivatives as Urease Inhibitors: Synthesis, Molecular Docking, Kinetic Studies and ADME Profile

Pharmaceuticals, 2022
The rapid development of resistance by ureolytic bacteria which are involved in various life-threatening conditions such as gastric and duodenal cancer has induced the need to develop a new line of therapy which has anti-urease activity.
Ayesha Naseer, Faisal Abdulrhman Osra, Asia Naz Awan, Aqeel Imran, Abdul Hameed, Syed Adnan Ali Shah, Jamshed Iqbal, Zainul Amiruddin Zakaria   +7 more
doaj   +1 more source

Synthesis and Biological Evaluation of 1-(2-(6-Methoxynaphthalen-2-yl)-6-methylnicotinoyl)-4-Substituted Semicarbazides/Thiosemicarbazides as Anti-Tumor Nur77 Modulators

Molecules, 2022
Nur77 is an orphan nuclear receptor that participates in the occurrence and development of a variety of tumors. Many agonists of Nur77 have been reported to have significant anticancer effects.
Hongyu Hu, Jiangang Huang, Yin Cao, Zhaolin Zhang, Fengming He, Xianfu Lin, Qi Wu, Shengxian Zhao   +7 more
doaj   +1 more source

Synthesis and Structure Determination of Substituted Thiazole Derivatives as EGFR/BRAF^V600E Dual Inhibitors Endowed with Antiproliferative Activity

Pharmaceuticals, 2023
2,3,4-trisubstituted thiazoles 3a–i, having a methyl group in position four, were synthesized by the reaction of 1,4-disubstituted thiosemicarbazides with chloroacetone in ethyl acetate/Et3N at room temperature or in ethanol under reflux.
Lamya H. Al-Wahaibi, Essmat M. El-Sheref, Alaa A. Hassan, S. Bräse, M. Nieger, Bahaa G. M. Youssif, Mahmoud A. A. Ibrahim, Hendawy N. Tawfeek   +7 more
doaj   +1 more source