Results 31 to 40 of about 8,698 (205)

Synthesis, characterization, antimicrobial, and pharmacological evaluation of some 2, 5-disubstituted sulfonyl amino 1,3,4-oxadiazole and 2-amino-disubstituted 1,3,4-thiadiazole derivatives

Journal of Advanced Pharmaceutical Technology & Research, 2014
The presence of heterocyclic structures in diverse types of compounds, this is strongly indicative of the profound effect like structure exerts on physiologic activity, and recognition of this is abundantly reflected in efforts to find useful synthetic ...
Dilipkumar Pal, Rohit Tripathi, Desh Deepak Pandey, Preety Mishra   +3 more
doaj   +1 more source

Reactivity of 4,5-Dichlorophthalic Anhydride towards Thiosemicarbazide and Amines: Synthesis, Spectroscopic Analysis, and DFT Study

Molecules, 2022
The cyclic anhydrides are broadly employed in several fields, such as the chemical, plastic, agrochemical, and pharmaceutical industries. This study describes the chemical reactivity of 4,5-dichlorophthalic anhydride towards several nucleophiles ...
Hatem A. Abuelizz, Ahmed H. Bakheit, Mohamed Marzouk, Mohamed M. Abdellatif, Rashad Al-Salahi   +4 more
doaj   +1 more source

Pharmacological and Structure-Activity Relationship Evaluation of 4-aryl-1-Diphenylacetyl(thio)semicarbazides [PDF]

, 2014
This article describes the synthesis of six 4-aryl-(thio)semicarbazides (series a and b) linked with diphenylacetyl moiety along with their pharmacological evaluation on the central nervous system in mice and computational studies, including ...
Fidecka, Sylwia, Kuśmierz, Edyta, Kędzierska, Ewa, Orzelska, Jolanta, Paneth, Agata, Paneth, Piotr, Plech, Tomasz, Wróbel, Andrzej, Wujec, Monika   +8 more
core   +2 more sources

4α,14α,Dimethyl-5α-cholest-8-en-3-one thiosemicarbazone

Molbank, 2006
n ...
Noureddine Mazoir, My Youssef Ait Itto, Matías Reina Artiles, Ahmed Benharref   +3 more
doaj   +1 more source

UV-visible and $^1H-^{15}N$ NMR spectroscopic studies of colorimetric thiosemicarbazide anion sensors [PDF]

, 2015
Four model thiosemicarbazide anion chemosensors containing three N – H bonds, substituted with phenyl and/or 4-nitrophenyl units, were synthesised and studied for their anion binding abilities with hydroxide, fl uoride, acetate, dihydrogen phosphate
Agnieszka Podborska, Amendola, Amendola, Amendola, Amendola, Boiocchi, Boiochhi, Bonizzoni, Bordwell, Caltagirone, Cametti, Camiolo, Cho, Damjan Makuc, David C. Magri, de Silva, Duke, Duke, Duke, Esteban-Gómez, Esteban-Gómez, Evans, Evans, Gale, Gale, Gale, Gale, Gale, Gunnlaugsson, Gunnlaugsson, Gunnlaugsson, He, Janez Plavec, Konrad Szaciłowski, Kristina N. Farrugia, Kubik, Kubik, Li, Li, Li, Liu, Makuc, Makuc, Makuc, Makuc, Martin, Martínez-Máñez, Mason, Misra, Miyaji, Nie, Paduka Ali, Pandurangan, Pandurangan, Piela, Santos-Figueroa, Sessler, Shao, Suksai, Tetilla, Wenzel, Witanowski, Wu   +62 more
core   +1 more source

Synthesis of Novel Triazinoindole-Based Thiourea Hybrid: A Study on α-Glucosidase Inhibitors and Their Molecular Docking

Molecules, 2019
A new class of triazinoindole-bearing thiosemicarbazides (1−25) was synthesized and evaluated for α-glucosidase inhibitory potential. All synthesized analogs exhibited excellent inhibitory potential, with IC50 values ranging from 1.30 ± 0.
Muhammad Taha, Foziah J. Alshamrani, Fazal Rahim, Shawkat Hayat, Hayat Ullah, Khalid Zaman, Syahrul Imran, Khalid Mohammed Khan, Farzana Naz   +8 more
doaj   +1 more source

N-Substituted 2-(Benzenosulfonyl)-1-Carbotioamide Derivatives Exert Antimicrobial and Cytotoxic Effects via Aldehyde Dehydrogenase Pathway: Synthesis, In Silico and In Vitro Studies

Pharmaceuticals, 2023
A series of N-Substituted 2-(benzenosulfonyl)-1-carbotioamide derivatives (WZ1–WZ4) were synthesized and characterized using spectral methods. A comprehensive activity study was performed for each compound.
Lucja Walczak-Nowicka, Anna Biernasiuk, Wojciech Ziemichód, Zbigniew Karczmarzyk, Mateusz Kwaśnik, Paweł Kozyra, Waldemar Wysocki, Agnieszka Stenzel-Bembenek, Dorota Kowalczuk, Mariola Herbet, Monika Pitucha   +10 more
doaj   +1 more source

An Efficient and One Spot Synthesis of Silica Supported Synthesis of Fluorinated 1,3,4-Thiadiazole Derivative Under Microwave Irradiation

To Chemistry Journal, 2020
An efficient and one pot reaction of fluorinated 1,3,4-Thiadiazole derivatives  was synthesis by fluorinated  aromatic carboxylic with thiosemicabazide in the presence of phosphorus oxychloride as a catalyst under Microwave irradiation with silica ...
Bharat K Dhotre, Bhagwan Singh Dobhalb, Santosh Raut, Amol Kalea, Pathan Mohd Arif   +4 more
doaj   +2 more sources

Synthesis, Molecular Docking and Anticancer Activity of Diflunisal Derivatives as Cyclooxygenase Enzyme Inhibitors

Molecules, 2018
Cyclooxygenase enzymes play a vital role in inflammatory pathways in the human body. Apart from their relation with inflammation, the additional involvement of COX-2 enzyme with cancer activity was recently discovered.
Göknil Pelin Coşkun, Teodora Djikic, Taha Bartu Hayal, Nezaket Türkel, Kemal Yelekçi, Fikrettin Şahin, Ş. Güniz Küçükgüzel   +6 more
doaj   +1 more source

Novel bis(thiosemicarbazones) of the 3,5-diacetyl-1,2,4-triazol series and their platinum(ii) complexes: chemistry, antiproliferative activity and preliminary nephrotoxicity studies [PDF]

, 2011
Dalton Transactions 40.21 (2011): 5738-5745. Reproduced by permission of The Royal Society of ChemistryThe preparation and characterization of three novel 4N- monosubstituted bis(thiosemicarbazone) ligands of 3,5-diacetyl-1,2,4-triazol series and their ...
Hernández, Carolina, Matesanz, Ana I., Rodríguez, Ana, Souza, Pilar   +3 more
core   +2 more sources