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Application of third-generation sequencing to herbal genomics [PDF]
Frontiers in Plant Science, 2023 There is a long history of traditional medicine use. However, little genetic information is available for the plants used in traditional medicine, which limits the exploitation of these natural resources. Third-generation sequencing (TGS) techniques have
Longlong Gao +3 more
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Identification of rare thalassemia variants using third-generation sequencing
Frontiers in Genetics, 2023 Routine PCR, Sanger sequencing, and specially designed GAP-PCR are often used in the genetic analysis of thalassemia, but all these methods have limitations.
Qin Liu +11 more
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Benchmarking second and third-generation sequencing platforms for microbial metagenomics
Scientific Data, 2022 Measurement(s) mock community • Metagenomic profiling Technology Type(s) Illumina HiSeq 3000 • ThermoFisher Ion Proton and GeneStudio S5 • MGI DNBseq G400 and T7 • Oxford Nanopore Sequencing • PacBio Sequel System • Genome mapping and assembly Sample ...
Victoria Meslier +7 more
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Viral oncogenes, viruses, and cancer: a third-generation sequencing perspective on viral integration into the human genome [PDF]
Frontiers in Oncology, 2023 The link between viruses and cancer has intrigued scientists for decades. Certain viruses have been shown to be vital in the development of various cancers by integrating viral DNA into the host genome and activating viral oncogenes.
Ruichen Ye +9 more
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The Third-Generation Sequencing Challenge: Novel Insights for the Omic Sciences [PDF]
BiomoleculesThe understanding of the human genome has been greatly improved by the advent of next-generation sequencing technologies (NGS). Despite the undeniable advantages responsible for their widespread diffusion, these methods have some constraints, mainly ...
Carmela Scarano +5 more
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Analysis of rare thalassemia genetic variants based on third-generation sequencing [PDF]
Scientific Reports, 2022 Thalassemia is a group of common hereditary anemias that cause significant morbidity and mortality worldwide. However, precisely diagnosing thalassemia, especially rare thalassemia variants, is still challenging.
Cuiting Peng +11 more
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Diagnostics, 2023 Thalassemia is one of the most heterogeneous diseases, with more than a thousand mutation types recorded worldwide. Molecular diagnosis of thalassemia by conventional PCR-based DNA analysis is time- and resource-consuming owing to the phenotype ...
Syahzuwan Hassan +7 more
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Application of third-generation sequencing in cancer research [PDF]
Medical Review, 2021 In the past several years, nanopore sequencing technology from Oxford Nanopore Technologies (ONT) and single-molecule real-time (SMRT) sequencing technology from Pacific BioSciences (PacBio) have become available to researchers and are currently being ...
Chen Zhiao, He Xianghuo
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Third Generation Sequencing of Epigenetic DNA.
Angewandte Chemie, 2022 The discovery of epigenetic bases has revolutionised the understanding of disease and development. Among the most studied epigenetic marks are cytosines covalently modified at the 5 position.
Bethany Searle +3 more
semanticscholar +4 more sources
3GOLD: optimized Levenshtein distance for clustering third-generation sequencing data [PDF]
BMC Bioinformatics, 2022 Background Third-generation sequencing offers some advantages over next-generation sequencing predecessors, but with the caveat of harboring a much higher error rate. Clustering-related sequences is an essential task in modern biology.
Robert Logan +6 more
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