Results 21 to 30 of about 1,856 (207)
Third‐Generation Sequencing of Epigenetic DNA
Angewandte Chemie, 2023 AbstractThe discovery of epigenetic bases has revolutionised the understanding of disease and development. Among the most studied epigenetic marks are cytosines covalently modified at the 5 position. In order to gain insight into their biological significance, the ability to determine their spatiotemporal distribution within the genome is essential ...
Bethany Searle +3 more
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The Third-Generation Sequencing Challenge: Novel Insights for the Omic Sciences
BiomoleculesThe understanding of the human genome has been greatly improved by the advent of next-generation sequencing technologies (NGS). Despite the undeniable advantages responsible for their widespread diffusion, these methods have some constraints, mainly ...
Carmela Scarano +5 more
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A window into third generation sequencing [PDF]
Human Molecular Genetics, 2010 First- and second-generation sequencing technologies have led the way in revolutionizing the field of genomics and beyond, motivating an astonishing number of scientific advances, including enabling a more complete understanding of whole genome sequences and the information encoded therein, a more complete characterization of the methylome and ...
Eric E, Schadt +2 more
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Advances and Trends in Omics Technology Development
Frontiers in Medicine, 2022 The human history has witnessed the rapid development of technologies such as high-throughput sequencing and mass spectrometry that led to the concept of “omics” and methodological advancement in systematically interrogating a cellular system.
Xiaofeng Dai, Li Shen
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SequelTools: a suite of tools for working with PacBio Sequel raw sequence data
BMC Bioinformatics, 2020 Background PacBio sequencing is an incredibly valuable third-generation DNA sequencing method due to very long read lengths, ability to detect methylated bases, and its real-time sequencing methodology.
David E. Hufnagel +2 more
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Frontiers in Genetics, 2020 DNA N6-methyladenine (6mA) modification has been discovered as the most prevalent DNA modification in prokaryotes and eukaryotes, involving gene expression, DNA replication and repair, and host-pathogen interactions. Single-molecule real-time sequencing (
Siqian Yang +3 more
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Fertility & Reproduction, 2023 Background and Aims: In in vitro fertilization (IVF) cycles, some patients suffering with vaginosis showed poor reproductive outcome even transferring with good quality embryos.
Wei-Fang Chang +11 more
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Advances in Metagenomics and Its Application in Environmental Microorganisms
Frontiers in Microbiology, 2021 Metagenomics is a new approach to study microorganisms obtained from a specific environment by functional gene screening or sequencing analysis.
Lu Zhang +14 more
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Third generation indexing for third generation sequencing [PDF]
, 2020 Abstract Indexing of DNA sequences is the art of sorting massive genomic data in a user-friendly structure to enable rapid accessing and comparing of different patterns in the data. Current genome assemblers use general algorithms for string indexing that do not exploit the special structural arrangement of genomes ...
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Analysis of Splicing Regulation by Third-Generation Sequencing
, 2022 In Metazoa, the diversity of transcripts produced by the RNA Polymerase II is generated essentially through post-transcriptional processing of the nascent transcripts. The regulation of exon inclusion by alternative splicing is one of the main sources of this diversity, which leads to the expansion of the proteome.
Allemand, Eric, Ango, Fabrice
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