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Advances and Trends in Omics Technology Development

Frontiers in Medicine, 2022
The human history has witnessed the rapid development of technologies such as high-throughput sequencing and mass spectrometry that led to the concept of “omics” and methodological advancement in systematically interrogating a cellular system.
Xiaofeng Dai, Li Shen
doaj   +1 more source

High-throughput and high-sensitivity full-length single-cell RNA-seq analysis on third-generation sequencing platform

Cell Discovery, 2023
The advancement of single-cell RNA-seq technologies based on third-generation sequencing (TGS) platforms has accelerated biological researches. Several TGS platform-based single-cell RNA-seq methods have been developed since 2016 1 .
Y. Liao, Zhenyu Liu, Yu Zhang, Ping Lu, Lu Wen, Fuchou Tang   +5 more
semanticscholar   +1 more source

SequelTools: a suite of tools for working with PacBio Sequel raw sequence data

BMC Bioinformatics, 2020
Background PacBio sequencing is an incredibly valuable third-generation DNA sequencing method due to very long read lengths, ability to detect methylated bases, and its real-time sequencing methodology.
David E. Hufnagel, Matthew B. Hufford, Arun S. Seetharam   +2 more
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Amplicon-Based Microbiome Profiling: From Second- to Third-Generation Sequencing for Higher Taxonomic Resolution

Genes, 2023
The 16S rRNA amplicon-based sequencing approach represents the most common and cost-effective strategy with great potential for microbiome profiling.
E. Notario, Grazia Visci, B. Fosso, C. Gissi, N. Tanaskovic, M. Rescigno, M. Marzano, G. Pesole   +7 more
semanticscholar   +1 more source

MASQC: Next Generation Sequencing Assists Third Generation Sequencing for Quality Control in N6-Methyladenine DNA Identification

Frontiers in Genetics, 2020
DNA N6-methyladenine (6mA) modification has been discovered as the most prevalent DNA modification in prokaryotes and eukaryotes, involving gene expression, DNA replication and repair, and host-pathogen interactions. Single-molecule real-time sequencing (
Siqian Yang, Yaoxin Wang, Ying Chen, Qi Dai   +3 more
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Comparison of Third-Generation Sequencing Technology and Traditional Microbiological Detection in Pathogen Diagnosis of Lower Respiratory Tract Infection.

Discover medicine, 2023
BACKGROUND It is common to obtain a low detection rate and unsatisfactory detection results in complex infection or rare pathogen detection. This retrospective study aimed to illustrate the application value and prospect of the third-generation ...
Wang-chi Luo, Yanbin He, Jianhui Xu, Shuhua Zhang, Chunxi Li, Jiangfeng Lv, Youfeng Shen, Zhao Ou, H. Dong   +8 more
semanticscholar   +1 more source

Advances in Metagenomics and Its Application in Environmental Microorganisms

Frontiers in Microbiology, 2021
Metagenomics is a new approach to study microorganisms obtained from a specific environment by functional gene screening or sequencing analysis.
Lu Zhang, FengXin Chen, Zhan Zeng, Mengjiao Xu, Fangfang Sun, Liu Yang, Xiaoyue Bi, Yanjie Lin, YuanJiao Gao, HongXiao Hao, Wei Yi, Minghui Li, Minghui Li, Yao Xie, Yao Xie   +14 more
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Back-to-Back Comparison of Third-Generation Sequencing and Next-Generation Sequencing in Carrier Screening of Thalassemia.

Archives of Pathology & Laboratory Medicine, 2023
CONTEXT.— Recently, new technologies, such as next-generation sequencing and third-generation sequencing, have been used in carrier screening of thalassemia. However, there is no direct comparison between the 2 methods in carrier screening of thalassemia.
Renliang Huang, Yinyin Liu, Jing Xu, Dan Lin, Aiping Mao, Liuqing Yang, Gaobu Zhong, Huoniao Wang, Ruofan Xu, Yiwei Chen, Qiaomiao Zhou   +10 more
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#201 : Comparison of the Sensitivity of Detecting Cervical Bacteria with Next Generation Sequencing and Third Generation Sequencing Technologies

Fertility & Reproduction, 2023
Background and Aims: In in vitro fertilization (IVF) cycles, some patients suffering with vaginosis showed poor reproductive outcome even transferring with good quality embryos.
Wei-Fang Chang, Shu-Min Chang, Pei-Ling Chu, Yi-Hsiu Chen, Rui-Hua Lee, Yi-Xuan Lee, Shun-Jen Tan, Ruey-Sheng Wang, Jason Yen-Ping Ho, Shyr-Yeu Lin, Chii-Ruey Tzeng, Yu-Ming Hu   +11 more
doaj   +1 more source

Third generation indexing for third generation sequencing [PDF]

, 2020
AbstractIndexing of DNA sequences is the art of sorting massive genomic data in a user-friendly structure to enable rapid accessing and comparing of different patterns in the data. Current genome assemblers use general algorithms for string indexing that do not exploit the special structural arrangement of genomes.
openaire   +1 more source