Results 21 to 30 of about 884,760 (321)

Third-Generation Sequencing: The Spearhead towards the Radical Transformation of Modern Genomics

Life, 2021
Although next-generation sequencing (NGS) technology revolutionized sequencing, offering a tremendous sequencing capacity with groundbreaking depth and accuracy, it continues to demonstrate serious limitations.
Konstantina Athanasopoulou, Michaela A. Boti, P. Adamopoulos, P. Skourou, A. Scorilas   +4 more
semanticscholar   +1 more source

A window into third generation sequencing [PDF]

Human Molecular Genetics, 2010
First- and second-generation sequencing technologies have led the way in revolutionizing the field of genomics and beyond, motivating an astonishing number of scientific advances, including enabling a more complete understanding of whole genome sequences and the information encoded therein, a more complete characterization of the methylome and ...
Eric E, Schadt, Steve, Turner, Andrew, Kasarskis   +2 more
openaire   +3 more sources

Advances and Trends in Omics Technology Development

Frontiers in Medicine, 2022
The human history has witnessed the rapid development of technologies such as high-throughput sequencing and mass spectrometry that led to the concept of “omics” and methodological advancement in systematically interrogating a cellular system.
Xiaofeng Dai, Li Shen
doaj   +1 more source

High-throughput and high-sensitivity full-length single-cell RNA-seq analysis on third-generation sequencing platform

Cell Discovery, 2023
The advancement of single-cell RNA-seq technologies based on third-generation sequencing (TGS) platforms has accelerated biological researches. Several TGS platform-based single-cell RNA-seq methods have been developed since 2016 1 .
Y. Liao, Zhenyu Liu, Yu Zhang, Ping Lu, Lu Wen, Fuchou Tang   +5 more
semanticscholar   +1 more source

Amplicon-Based Microbiome Profiling: From Second- to Third-Generation Sequencing for Higher Taxonomic Resolution

Genes, 2023
The 16S rRNA amplicon-based sequencing approach represents the most common and cost-effective strategy with great potential for microbiome profiling.
E. Notario, Grazia Visci, B. Fosso, C. Gissi, N. Tanaskovic, M. Rescigno, M. Marzano, G. Pesole   +7 more
semanticscholar   +1 more source

SequelTools: a suite of tools for working with PacBio Sequel raw sequence data

BMC Bioinformatics, 2020
Background PacBio sequencing is an incredibly valuable third-generation DNA sequencing method due to very long read lengths, ability to detect methylated bases, and its real-time sequencing methodology.
David E. Hufnagel, Matthew B. Hufford, Arun S. Seetharam   +2 more
doaj   +1 more source

Comparison of Third-Generation Sequencing Technology and Traditional Microbiological Detection in Pathogen Diagnosis of Lower Respiratory Tract Infection.

Discover medicine, 2023
BACKGROUND It is common to obtain a low detection rate and unsatisfactory detection results in complex infection or rare pathogen detection. This retrospective study aimed to illustrate the application value and prospect of the third-generation ...
Wang-chi Luo, Yanbin He, Jianhui Xu, Shuhua Zhang, Chunxi Li, Jiangfeng Lv, Youfeng Shen, Zhao Ou, H. Dong   +8 more
semanticscholar   +1 more source

Advances in Metagenomics and Its Application in Environmental Microorganisms

Frontiers in Microbiology, 2021
Metagenomics is a new approach to study microorganisms obtained from a specific environment by functional gene screening or sequencing analysis.
Lu Zhang, FengXin Chen, Zhan Zeng, Mengjiao Xu, Fangfang Sun, Liu Yang, Xiaoyue Bi, Yanjie Lin, YuanJiao Gao, HongXiao Hao, Wei Yi, Minghui Li, Minghui Li, Yao Xie, Yao Xie   +14 more
doaj   +1 more source

#201 : Comparison of the Sensitivity of Detecting Cervical Bacteria with Next Generation Sequencing and Third Generation Sequencing Technologies

Fertility & Reproduction, 2023
Background and Aims: In in vitro fertilization (IVF) cycles, some patients suffering with vaginosis showed poor reproductive outcome even transferring with good quality embryos.
Wei-Fang Chang, Shu-Min Chang, Pei-Ling Chu, Yi-Hsiu Chen, Rui-Hua Lee, Yi-Xuan Lee, Shun-Jen Tan, Ruey-Sheng Wang, Jason Yen-Ping Ho, Shyr-Yeu Lin, Chii-Ruey Tzeng, Yu-Ming Hu   +11 more
doaj   +1 more source

Third generation indexing for third generation sequencing [PDF]

, 2020
AbstractIndexing of DNA sequences is the art of sorting massive genomic data in a user-friendly structure to enable rapid accessing and comparing of different patterns in the data. Current genome assemblers use general algorithms for string indexing that do not exploit the special structural arrangement of genomes.
openaire   +1 more source