Results 61 to 70 of about 35,334 (222)
Engineered Exosome‐Based Senolytic Therapy Alleviates Stroke by Targeting p21+CD86+ Microglia
Exploration, EarlyView.We identified a harmful immune cell type, p21+CD86+ microglia, driving post‐stroke inflammation and developed a targeted exosome‐based therapy (Que@micro‐Exo) to eliminate these cells. This innovative treatment reduced inflammation, alleviated brain damage, and improved recovery in stroke models, offering a promising strategy for stroke and other ...
Jialei Yang, Shipo Wu, Miao He
wiley +1 more source
Exploration, EarlyView.Selenium (Se) is a crucial element in selenoproteins, key biomolecules for physiological function in vivo. Central nervous system can express all 25 kinds of selenoproteins, which protect neurons by reducing oxidative stress and inflammatory response. Neuroprotection is being investigated through the biological study of Se.
Guanning Huang +4 more
wiley +1 more source
Journal of Operations Management, EarlyView.ABSTRACT Stroke is a highly time‐sensitive medical emergency, and earlier treatment is crucial. Drawing on Temporal Motivation Theory, we investigate a “deadline effect” in stroke care and analyze how two deadlines, that is, a medically oriented one (administering Tissue Plasminogen Activator, TPA, within 4.5 h of symptom onset) and a goal‐oriented one
Brandon Lee +2 more
wiley +1 more source
Pharmacotherapy for Cirrhosis in Japan
Portal Hypertension &Cirrhosis, EarlyView.As cirrhosis progresses from the compensated to the decompensated stage, liver disease‐related events such as varices, ascites, encephalopathy, sarcopenia, jaundice, and bleeding tendency, as well as liver carcinogenesis, can occur at a high rate. With the advent of new pharmacotherapies for cirrhosis in the last decade, liver fibrosis has been shown ...
Hiroki Nishikawa, Soo Ki Kim, Akira Asai
wiley +1 more source
Small Structures, EarlyView.Low‐intensity focused ultrasound (LIFU)‐responsive nanobubbles (PAF@M) specifically target thrombus sites and penetrate thrombi under LIFU stimulation. Meanwhile, the liquid–gas phase transition of perfluoropentane and the release of nitric oxide synergistically enhance ultrasonic cavitation to destroy thrombus structure, providing a safe and effective
Wenli Zhang +15 more
wiley +1 more source
Management of Acute Superior Mesenteric Artery Occlusion by Thrombolytic Therapy
Case Reports in Gastroenterology, 2009 Acute occlusion of the superior mesenteric artery (SMA) causes extensive bowel necrosis, resulting in a poor prognosis with an extremely high mortality rate. An 82-year-old woman was admitted to our hospital with the complaint of abdominal pain.
Shinichi Okamura +13 more
doaj +1 more source
The origin of thrombolytic therapy
Journal of the American College of Cardiology, 1989 The origin of thrombolytic therapy is briefly reviewed. It began 40 years ago with the demonstration that the injection into patients of a partially purified activator of the native plasminogen-plasmin enzyme system was capable of dissolving clotted blood and fibrinous loculations in the chest.
openaire +3 more sources
Global emergency medicine: A scoping review of the literature from 2023
Academic Emergency Medicine, EarlyView.Abstract Objective The Global Emergency Medicine Literature Review (GEMLR) highlights the highest‐quality research addressing emergency care in resource‐limited settings (ECRLS). This 18th edition reviews global emergency medicine (GEM) literature published during 2023.
Braden J. Hexom +76 more
wiley +1 more source
European Journal of Neuroscience, Volume 60, Issue 7, Page 5450-5466, October 2024.We studied the impact of circadian misalignment on 238 plasma proteins linked to cardiovascular physiology. We identified 42 proteins with altered abundance, five proteins regulated by the circadian clock, and changes in many proteins in the coagulation pathway.
Andrew W. McHill +3 more
wiley +1 more source