Results 21 to 30 of about 111,761,861 (179)

A Heterologous Model of Thrombospondin Type 1 Domain-Containing 7A-Associated Membranous Nephropathy. [PDF]

J Am Soc Nephrol, 2017
Thrombospondin type 1 domain-containing 7A (THSD7A) is a target for autoimmunity in patients with membranous nephropathy (MN). Circulating autoantibodies from patients with THSD7A-associated MN have been demonstrated to cause MN in mice.
Tomas NM, Meyer-Schwesinger C, von Spiegel H, Kotb AM, Zahner G, Hoxha E, Helmchen U, Endlich N, Koch-Nolte F, Stahl RAK.   +9 more
europepmc   +4 more sources

Autoantibodies against thrombospondin type 1 domain-containing 7A induce membranous nephropathy. [PDF]

J Clin Invest, 2016
Membranous nephropathy (MN) is the most common cause of nephrotic syndrome in adults, and one-third of patients develop end-stage renal disease (ESRD). Circulating autoantibodies against the podocyte surface antigens phospholipase A2 receptor 1 (PLA2R1) and the recently identified thrombospondin type 1 domain-containing 7A (THSD7A) are assumed to cause
Tomas NM, Hoxha E, Reinicke AT, Fester L, Helmchen U, Gerth J, Bachmann F, Budde K, Koch-Nolte F, Zahner G, Rune G, Lambeau G, Meyer-Schwesinger C, Stahl RA.   +13 more
europepmc   +4 more sources

Research progress on the pathogenesis of primary membranous nephropathy [PDF]

Guangxi Yike Daxue xuebao
This article reviews the pathogenesis of primary membranous nephropathy (PMN) in recent years, encompassing the latest findings of genetic, antigenic, environmental factors, and intestinal flora, etc., so as to provide a reference for further ...
LIU Jianing, ZHU Junjie, LIU Yun, CEN Tao, ZHANG Li'e, NONG Qingqing   +5 more
doaj   +2 more sources

Thrombospondin Type 1 Domain-Containing 7A Localizes to the Slit Diaphragm and Stabilizes Membrane Dynamics of Fully Differentiated Podocytes. [PDF]

J Am Soc Nephrol, 2019
Significance Statement Among adults with membranous nephropathy, about 3%–5% have autoantibodies directed against thrombospondin type 1 domain–containing 7A (THSD7A), a podocyte-expressed transmembrane protein.
Herwig J, Skuza S, Sachs W, Sachs M, Failla AV, Rune G, Meyer TN, Fester L, Meyer-Schwesinger C.   +8 more
europepmc   +4 more sources

An Indirect Immunofluorescence Method Facilitates Detection of Thrombospondin Type 1 Domain-Containing 7A-Specific Antibodies in Membranous Nephropathy. [PDF]

J Am Soc Nephrol, 2017
Thrombospondin type 1 domain–containing 7A (THSD7A) is a target antigen identified in adult membranous nephropathy (MN) along with the major antigen phospholipase A 2 receptor 1 (PLA 2 R1).
Hoxha E, Beck LH, Wiech T, Tomas NM, Probst C, Mindorf S, Meyer-Schwesinger C, Zahner G, Stahl PR, Schöpper R, Panzer U, Harendza S, Helmchen U, Salant DJ, Stahl RA.   +14 more
europepmc   +4 more sources

TRIM25 facilitates mitochondrial dysfunction and extracellular matrix degradation by enhancing USP7-driven ENO1 deubiquitination during intervertebral disc degeneration. [PDF]

Clin Transl Med
Under conditions of low TRIM25 expression, the ubiquitination fate of ENO1 shifts to K48‐linked ubiquitination and degradation. TRIM25 enhances the deubiquitination of ENO1 by recruiting USP7, effectively inhibiting its proteasomal degradation and significantly increasing ENO1 stabilization.
Liu X, Zhang W, Feng H, Lai L, Cao C, Yang G, Gao Y, Wang B, Wang H, Yu B, Yu Z.   +10 more
europepmc   +2 more sources

Recurrent membranous nephropathy with a possible alteration in the etiology: a case report

BMC Nephrology, 2021
Background Phospholipase A2 receptor 1 (PLA2R1) and thrombospondin type-1 domain-containing 7A (THSD7A) are the two major pathogenic antigens for membranous nephropathy (MN).
Ayumi Matsumoto, Isao Matsui, Keiji Mano, Hitoshi Mizuno, Yusuke Katsuma, Seiichi Yasuda, Karin Shimada, Kazunori Inoue, Takashi Oki, Tadashi Hanai, Keiko Kojima, Tetsuya Kaneko, Yoshitaka Isaka   +12 more
doaj   +1 more source

Clinical significance of the determination of antibodies to thrombospondin type 1 containing domain 7A (THSD7A) in membranous nephropathy

Терапевтический архив, 2023
Background. Membranous nephropathy (MN) is an immunocomplex glomerular disease, which is the most common cause of nephrotic syndrome in adults. Numerous studies have established that autoantibodies against the target podocyte autoantigens, including the ...
Patimat A. Kakhsurueva, Elena S. Kamyshova, Irina N. Bobkova, Ekaterina V. Stavrovskaya, Tatiana E. Rudenko, Elena Y. Andreeva   +5 more
doaj   +1 more source

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

A Genetic Risk Score Distinguishes Different Types of Autoantibody-Mediated Membranous Nephropathy

Glomerular Diseases, 2023
Introduction: Membranous nephropathy (MN) is the leading cause of nephrotic syndrome in adults and is characterized by detectable autoantibodies against glomerular antigens, most commonly phospholipase A2 receptor 1 (PLA2R1) and thrombospondin type-1 ...
Sanjana Gupta, Mallory Louise Downie, Chris Cheshire, Stephanie Dufek-Kamperis, Adam Paul Levine, Paul Brenchley, Elion Hoxha, Rolf Stahl, Neil Ashman, Ruth Jennifer Pepper, Sean Mason, Jill Norman, Detlef Bockenhauer, Horia Constantin Stanescu, Robert Kleta, Daniel Philip Gale   +15 more
doaj   +1 more source