Results 41 to 50 of about 111,761,861 (179)

The Alternative Pathway Is Necessary and Sufficient for Complement Activation by Anti-THSD7A Autoantibodies, Which Are Predominantly IgG4 in Membranous Nephropathy

Frontiers in Immunology, 2022
Membranous nephropathy (MN) is an immune kidney disease characterized by glomerular subepithelial immune complexes (ICs) containing antigen, IgG, and products of complement activation. Whereas proteinuria is caused by complement-mediated podocyte injury,
Pallavi Manral, Tiffany N. Caza, Aaron J. Storey, Laurence H. Beck, Dorin-Bogdan Borza   +4 more
doaj   +1 more source

O-Glycosylation of thrombospondin type 1 repeats : identification and characterisation of β1,3-glucosyltransferase [PDF]

, 2008
Rare types of protein glycosylation often occur in a domain-specific manner required for important biological functions (Okajima et al. 2008). O-linked fucosylation, where the fucose is linked directly to the hydroxyl groups of serine or threonine ...
Keusch, Krisztina
core   +1 more source

THSD7A-associated membranous nephropathy involves both complement-mediated and autonomous podocyte injury

Translation
Membranous nephropathy (MN) continues to be a leading cause of nephrotic syndrome in non-diabetic adults. As a unique subtype in the serology-based classification of MN, thrombospondin type 1 domain containing 7A (THSD7A)-associated MN has attracted ...
Jing Liu, Deepak Malhotra, Yan Ge, William Gunning, Lance Dworkin, Rujun Gong   +5 more
doaj   +3 more sources

Segmental Membranous Glomerulopathy in Adults

Kidney Diseases, 2023
Introduction: The clinicopathological features of segmental membranous glomerulopathy (SMGN) have not been well characterized. The aim of this study was to investigate the prevalence and clinicopathological features of SMGN in adults.
Shuangshuang Zhu, Xiaoting Liu, Shuling Yue, Bei Luo, Zhen Song, Xiaomeng Xu, Lin Wang, Xiaotao Hou, Kongshan Li, Qiming Liang, Zheya Zhou, Wenfang Chen, Lei Zheng   +12 more
doaj   +1 more source

Thrombospondin Type-1 Repeat Domain-Containing Proteins Are Strongly Expressed in the Head Region of Hydra. [PDF]

, 2016
The head region of Hydra, the hypostome, is a key body part for developmental control and the nervous system. We herein examined genes specifically expressed in the head region of Hydra oligactis using suppression subtractive hybridization (SSH) cloning.
Nozomi Fukuoka (2590171), Osamu Koizumi (2590183), Manami Sato (2590180), Miyuki Matsufuji, Shun Hamada, Mami Kurumata-Shigeto (2590174), Sumiko Minobe, Osamu Koizumi, Manami Sato, Kayoko Hamaguchi-Hamada, Kayoko Hamaguchi-Hamada (2590177), Nozomi Fukuoka, Shun Hamada (2590168), Mami Kurumata-Shigeto, Sumiko Minobe (2590162), Miyuki Matsufuji (2590165)   +15 more
core   +1 more source

Case Report: THSD7A-Positive Membranous Nephropathy Caused by Tislelizumab in a Lung Cancer Patient

Frontiers in Immunology, 2021
Immune checkpoint inhibitors (ICIs) became the standard treatment for many different kinds of cancers and can result in a variety of immune-related adverse events (irAEs). IrAEs of kidney are uncommon and consists of different pathology types.
Minjiang Chen, Lei Zhang, Wei Zhong, Ke Zheng, Wei Ye, Mengzhao Wang   +5 more
doaj   +1 more source

ZBTB7A (zinc finger and BTB domain containing 7A) [PDF]

, 2011
Review on ZBTB7A (zinc finger and BTB domain containing 7A), with data on DNA, on the protein encoded, and where the gene is ...
Kotsinas, A, Apostolopoulou, K, Gorgoulis, VG, Pateras, IS   +3 more
core   +1 more source

Update on New Antigens in the Pathogenesis of Membranous Nephropathy

European Medical Journal, 2022
Previously, membranous nephropathies were divided into primary and secondary categories when the exact mechanism or pathogenetic factor were unknown. Approximately 70% accounted for primary membranous nephropathies.
Maurizio Salvadori, Aris Tsalouchos
doaj   +1 more source

Immunohistochemical analysis for thrombospondin type-1 domain-containing 7A (THSD7A) and M-type phospholipase A2 receptor (PLA2R).

, 2015
Immunostaining for THSD7A (a, c, e) and PLA2R (b, d, f) in patients with idiopathic membranous nephropathy (a–d) and secondary membranous nephropathy (e, f). Original magnification: ×400.
Hideo Yasuda (710367), Satoshi Baba (540358), Naro Ohashi (168272), Akihiko Kato (798462), Takamasa Iwakura (798461)   +4 more
core   +1 more source

Prevalence of neural epidermal growth factor-like 1- and exostosin 1/exostosin 2-associated membranous nephropathy: a single-center retrospective study in Japan

Scientific Reports, 2022
Membranous nephropathy (MN) is the leading cause of nephrotic syndrome in adults. We previously reported that the prevalence of phospholipase A2 receptor (PLA2R)- and thrombospondin type 1 domain containing 7A (THSD7A)-associated MN patients in Japan is ...
Takamasa Iwakura, Chiemi Ema, Shinsuke Isobe, Tomoyuki Fujikura, Naro Ohashi, Akihiko Kato, Hideo Yasuda   +6 more
doaj   +1 more source