Results 61 to 70 of about 111,761,861 (179)

Association of genetic variations of genes encoding thrombospondin, type 1, domain-containing 4 and 7A with low bone mineral density in Japanese women with osteoporosis [PDF]

Journal of Human Genetics, 2008
Twins and family studies have shown that genetic factors are important determinants of bone mass. Important aspects of bone mineral density (BMD) regulation are endocrine systems, notably hormonal regulation of adrenal corticoids, as indicated by clinical knowledge of glucocorticoid-induced osteoporosis.
Seijiro, Mori, Ikuyo, Kou, Hidenori, Sato, Mitsuru, Emi, Hideki, Ito, Takayuki, Hosoi, Shiro, Ikegawa   +6 more
openaire   +2 more sources

The histone deacetylase inhibitor, suberoylanilide hydroxamic acid, restores blood–brain barrier integrity in a human stem cell‐based model of ischaemic stroke

British Journal of Pharmacology, Volume 183, Issue 19, Page 5791-5812, October 2026.
Ischaemic stroke is characterised by acute cerebrovascular occlusion and blood–brain barrier (BBB) breakdown. Our results indicated that the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) ameliorated the loss of BBB integrity, changed the morphology of brain endothelial cells, increased the level of basement membrane and ...
Anikó Szecskó, Koppány Párdi, Zuhao Cui, Gergő Porkoláb, Zsófia Hoyk, Csilla Kovács, Janet F. Adegbite, Virág Fodor, Nárcisz M. Cser, László Dér, Krisztina Nagy, Csilla Sajben, Roland Tengölics, Mária A. Deli, Szilvia Veszelka   +14 more
wiley   +1 more source

Primary membranous nephropathy with concomitant IgA nephropathy

Saudi Journal of Kidney Diseases and Transplantation, 2019
Membranous nephropathy (MN), an autoimmune glomerulonephritis which can occur in primary and secondary forms, is one of the most common inflammatory glomerulopathies in elderly patients.
Reza Khorsan, Ramy M Hanna, Khalid Ameen, Farid Arman, Niloofar Nobakht, Huma Hasnain, Ashley Hyunh, Anjay Rastogi   +7 more
doaj   +1 more source

Distinct Complement Activation Profiles Between NELL1‐ and PLA2R‐Associated Membranous Nephropathy: A Clinicopathological and Proteomic Study

Nephrology, Volume 31, Issue 10, October 2026.
We compared the clinicopathological features and complement activation profiles of PLA2R‐associated and NELL1‐associated membranous nephropathy. NELL1‐associated membranous nephropathy was associated with older age, more chronic histologic changes and less glomerular C3 and C4d deposition.
Taihei Suzuki, Kang Dedong, Kunio Kawanishi, Masataka Ueda, Yuki Kajio, Kazuki Kobayashi, Nobuhiro Kanazawa, Mayumi Takahashi‐Kobayashi, Joichi Usui, Masaki Baba, Hirokazu Honda, Kazuho Honda, Masayuki Iyoda   +12 more
wiley   +1 more source

Contemporary review of primary membranous nephropathy

Frontiers in Immunology
Primary membranous nephropathy (PMN) is a single-organ autoimmune disease caused by autoantibodies targeting podocyte-associated antigens, most commonly phospholipase A2-receptor (PLA2R).
Edward J. Filippone, John L. Farber
doaj   +1 more source

TAIL1: an isthmin-like gene, containing type 1 thrombospondin-repeat and AMOP domain, mapped to ARVD1 critical region.

, 2004
Isthmins represent a novel family of vertebrate secreted proteins containing one copy of the thrombospondin type 1 repeat (TSR), which in mammals is shared by several proteins with diverse biological functions, including cell adhesion, angiogenesis, and ...
G. DANIELI, BAUCE, BARBARA, ROSSI V, BEFFAGNA, GIORGIA, RAMPAZZO, ALESSANDRA, Danieli, Gian Antonio, Rossi, Valeria   +6 more
core   +1 more source

Natural polymorphism in the thrombospondin-related adhesive protein of Plasmodium falciparum [PDF]

, 1998
We have developed a typing system using natural sequence variation in the thrombospondin-related adhesive protein (TRAP) gene of Plasmodium falciparum. This method permits a haplotype to be assigned to any particular TRAP gene.
Crisanti, Andrea, Keita, Mamadou M., Sidibe, Touman, T Sidibe, David Modiano, Dolo, Amagana, A Crisanti, M M Keita, Andrea Bosman, Mamadou M. Keita, Ogobara Doumbo, Bosman, Andrea, A Bosman, Hackford, Ian R., Martin B. Richards, O Doumbo, A Dolo, Ian R. Hackford, I R Hackford, Toumani Sidibe, Andrea Crisanti, M B Richards, Modiano, David, Amagana Dolo, Kathryn J. H. Robson, Robson, Kathryn J.H., K J Robson, D Modiano, Richards, Martin B., Doumbo, Ogobara   +29 more
core   +3 more sources

THBS1+ Macrophages Exacerbate Modic Changes via SDC4‐Dependent Activation of NLRP3 Inflammasome

Advanced Science, Volume 13, Issue 53, 24 September 2026.
The illustration of THBS1+ macrophages exacerbate MCs via SDC4‐dependent activation of the NLRP3 inflammasome. THBS1+ macrophage subpopulation was identified in MCs through single‐cell RNA sequencing. C. acnes and its metabolites activate THBS1 expression in macrophages via the TLR signaling pathway.
Xiangxi Kong, Qize Xue, Xiaoan Wei, Jie Li, Bao Huang, Weishao Chen, Zimin Cai, Tao Yang, Chengjun Yao, Jiayan Jin, Bohan Cai, Xuyang Zhang, Junhui Liu, Haihao Wu, Jian Chen, Zhi Shan, Fengdong Zhao   +16 more
wiley   +1 more source

Prevalence and prognosis of malignancy in THSD7A-associated membranous nephropathy: a systematic literature review and clinical case study

Renal Failure
Background This study aims to investigate the incidence and prognosis of malignancy in individuals with thrombospondin type-1 domain-containing 7A (THSD7A)-associated membranous nephropathy (MN).Methods First, we performed a systematic literature review ...
Qianqian Xu, Jiayi Li, Yue Yang, Li Zhuo, Hongmei Gao, Shimin Jiang, Wenge Li   +6 more
doaj   +1 more source

Immunological Pathogenesis of Membranous Nephropathy: Focus on PLA2R1 and Its Role

Frontiers in Immunology, 2019
Membranous nephropathy (MN) is the major cause of nephrotic syndrome with special pathological features, caused by the formation of immune complexes in the space between podocytes and the glomerular basement membrane. In idiopathic membranous nephropathy
Wenbin Liu, Wenbin Liu, Chang Gao, Chang Gao, Haoran Dai, Yang Zheng, Zhaocheng Dong, Zhaocheng Dong, Yu Gao, Yu Gao, Fei Liu, Zihan Zhang, Zhiyuan Liu, Weijing Liu, Baoli Liu, Qingquan Liu, Jialan Shi   +16 more
doaj   +1 more source