A case of IgG4-related disease and membranous nephropathy associated with thrombospondin type-1 domain-containing 7A [PDF]
Glomerular Diseases, 2022 Background IgG4-related disease (IgG4-RD) is a systemic multi-organ inflammatory disorder which affects the kidney 20% of the time. Patients with intrinsic IgG4-related kidney disease (IgG4-RKD) often have tubulointerstitial nephritis (TIN) whereas ...
Ryan Malcolm Hum +4 more
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Thrombospondin type-1 domain-containing 7A-associated membranous nephropathy after resection of rectal cancer: a case report [PDF]
BMC Nephrology, 2019 Background Thrombospondin type-1 domain-containing 7A (THSD7A) is a target antigen in idiopathic membranous nephropathy (MN). Patients with THSD7A-associated MN are known to have a high possibility of developing malignancy.
Shinya Taguchi +5 more
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Prevalence of Enhanced Granular Expression of Thrombospondin Type-1 Domain-Containing 7A in the Glomeruli of Japanese Patients with Idiopathic Membranous Nephropathy. [PDF]
PLoS ONE, 2015 Membranous nephropathy (MN) is a leading cause of nephrotic syndrome in adults. Autoantibodies against M-type phospholipase A2 receptor (PLA2R) and thrombospondin type-1 domain-containing 7A (THSD7A), which mainly belong to the IgG4 subclass, were ...
Takamasa Iwakura +4 more
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Clinical characteristics of thrombospondin type-1 domain-containing 7A-associated membranous nephropathy [PDF]
Renal Failure, 2020 Membranous nephropathy (MN) is a common cause of nephrotic syndrome. Phospholipase A2 receptor 1 (PLA2R) and thrombospondin type-1 domain-containing 7 A (THSD7A) present in the podocyte membrane ar...
Tomo Suzuki +7 more
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Aquaporin 1 elicits cell motility and coordinates vascular bed formation by downregulating thrombospondin type‐1 domain‐containing 7A in glioblastoma [PDF]
Cancer Medicine, 2020 Background Aquaporin (AQP) 1 expression has been linked with tumor malignancy but its role in glioblastoma (GBM), a lethal glioma, remains to be clarified. Methods AQP1 expression was examined in 33 human GBM specimens by immunohistochemistry. GBM cells (
Masahiro Oishi +5 more
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Thrombospondin Type-1 Domain-Containing 7A in Idiopathic Membranous Nephropathy [PDF]
New England Journal of Medicine, 2014 Idiopathic membranous nephropathy is an autoimmune disease. In approximately 70% of patients, it is associated with autoantibodies against the phospholipase A2 receptor 1 (PLA2R1). Antigenic targets in the remaining patients are unknown.Using Western blotting, we screened serum samples from patients with idiopathic membranous nephropathy, patients with
Elion Hoxha +2 more
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Structure and Function Insights Garnered From in Silico Modeling of the Thrombospondin Type-1 Domain-Containing 7A Antigen [PDF]
Proteins: Structure, Function and Bioinformatics, 2019 AbstractThe thrombospondin type‐1 domain containing 7A (THSD7A) protein is known to be one of the antigens responsible for the autoimmune disorder idiopathic membranous nephropathy. The structure of this antigen is currently unsolved experimentally. Here we present a homology model of the extracellular portion of the THSD7A antigen.
Shana V Stoddard +2 more
exaly +5 more sources
Unprovoked pulmonary embolism with bilateral deep vein thrombosis revealing occult nephrotic syndrome due to seronegative membranous nephropathy [PDF]
European Journal of Case Reports in Internal MedicineIntroduction: Nephrotic syndrome is a well-recognised risk factor for venous thromboembolism (VTE) but may present without oedema, hyperlipidaemia or impaired kidney function, delaying diagnosis. Case description: A 73-year-old man presented with fatigue,
Seyma Eser +3 more
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Optimization of a Target Antigen Diagnostic Pathway for Membranous Nephropathy [PDF]
Kidney International ReportsIntroduction: The recent Mayo Clinic consensus proposed a target antigen-based diagnostic pathway for membranous nephropathy (MN), recommending testing for neural epidermal growth factor-like 1 (NELL1) following a negative phospholipase A2 receptor ...
Wangyang Li +15 more
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Animal models of idiopathic membranous nephropathy: Recent advances and future perspectives [PDF]
Animal Models and Experimental MedicineIdiopathic membranous nephropathy (IMN) is one of the main causes of adult nephrotic syndrome. A subset of untreated or inadequately treated patients eventually progress to end‐stage renal disease (ESRD), posing a significant clinical challenge. Although
Qiuying Liu +6 more
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