Results 31 to 40 of about 111,761,865 (181)
A Genetic Risk Score Distinguishes Different Types of Autoantibody-Mediated Membranous Nephropathy
Glomerular Diseases, 2023 Introduction: Membranous nephropathy (MN) is the leading cause of nephrotic syndrome in adults and is characterized by detectable autoantibodies against glomerular antigens, most commonly phospholipase A2 receptor 1 (PLA2R1) and thrombospondin type-1 ...
Sanjana Gupta +15 more
doaj +1 more source
Frontiers in Oncology, 2022 BackgroundTo investigate the relationship between membranous nephropathy (MN) and lung cancer.MethodsTo report patients with lung cancer detected by follow-up after the diagnosis of MN by renal biopsy in China-Japan Friendship Hospital from January 2010 ...
Qianqian Xu +4 more
doaj +1 more source
Frontiers in Medicine, 2021 We report a case of membranous nephropathy with monoclonal immunoglobulin (Ig)M lambda deposits in a patient with IgM monoclonal gammopathy, in whom histological changes were observed on repeat renal biopsy.
Go Hirose +8 more
doaj +1 more source
Integrative analysis of miRNA–mRNA network in idiopathic membranous nephropathy by bioinformatics analysis [PDF]
PeerJ, 2021 Background Currently, several specific antigens, M-type receptor for secretory phospholipase A2(PLA2R1), thrombospondin type-1 domain-containing 7A(THSD7A), and neural epidermal growth factor-like 1 protein (NELL-1), are discovered associated with the ...
Wenfang He +5 more
doaj +2 more sources
Kidney Medicine, 2021 Technological advances have allowed the discovery of 6 subtypes of membranous nephropathy based on target antigens: M-type phospholipase A2 receptor (PLA2R), thrombospondin type 1 domain-containing 7A (THSD7A), neural epidermal growth factor-like 1 ...
Takamasa Iwakura +7 more
doaj +1 more source
ITCH-Mediated Ubiquitination and Degradation of THBS1: A Key Mechanism for Enhancing Mitochondrial Biogenesis and Alleviating Mouse Skeletal Muscle Atrophy. [PDF]
Acta Physiol (Oxf)ABSTRACT Aim Skeletal muscle atrophy is tightly associated with maladaptive alterations in mitochondrial function and morphology. Itchy E3 ubiquitin‐protein ligase (ITCH) modulates mitochondria, and thrombospondin 1 (THBS1) positively regulates muscle atrophy, but their roles in muscle atrophy are unclear. Methods A muscle atrophy model was established
Yu W, Wang Y, Li N, Wang D.
europepmc +2 more sources
Structure of human POFUT2 : insights into thrombospondin type 1 repeat fold and O-fucosylation [PDF]
, 2012 Protein O-fucosylation is a post-translational modification found on epidermal growth factor-like (EGF) repeats and thrombospondin type 1 repeats (TSR).
Chun-I, Chen +12 more
core +1 more source
Differential expression of THSD7A in cancer of the vulva.
, 2021 In these brief notes we document work using published microarray data (1, 2) to pioneer integrative transcriptome analysis comparing vulvar carcinoma to its tissue of origin, the vulva.
Shahan Mamoor
core +1 more source
Expression of THSD7A in neoplasm tissues and its relationship with proteinuria
BMC Nephrology, 2019 Background Thrombospondin type 1 domain containing 7A (THSD7A) was recently identified target autoantigen in membranous nephropathy (MN). However, patients with positive THSD7A expression were prone to have malignancies.
Li Xian +10 more
doaj +1 more source
Membranous nephropathy: Clearer pathology and mechanisms identify potential strategies for treatment
Frontiers in Immunology, 2022 Primary membranous nephropathy (PMN) is one of the common causes of adult-onset nephrotic syndrome and is characterized by autoantibodies against podocyte antigens causing in situ immune complex deposition.
Edmund Y. M. Chung +14 more
doaj +1 more source