Results 61 to 70 of about 1,598,447 (336)
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Defining the elusive oncogenic role of the methyltransferase TMT1B
Frontiers in Oncology, 2023 Methyltransferases are enzymes fundamental to a wide range of normal biological activities that can become dysregulated during oncogenesis. For instance, the recent description of the methyltransferase-like (METTL) family of enzymes, has demonstrated the
Sarah E. Denford +2 more
doaj +1 more source
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Genome BiologyMicrobial pangenome analysis identifies present or absent genes in prokaryotic genomes. However, current tools are limited when analyzing species with higher sequence diversity or higher taxonomic orders such as genera or families.
Kevin Lamkiewicz +3 more
doaj +1 more source
Cancer Cell International, 2019 Background The abnormal expression of many long non-coding RNAs (lncRNAs) has been reported in the progression of various tumors. However, the potential biological roles and regulatory mechanisms of long non-coding RNAs in the development of colorectal ...
Qingmei Wang +8 more
doaj +1 more source
Effects of Transport Delays of Manual Control System Performance [PDF]
, 1984 Throughput or transport delays in manual control systems can cause degraded performance and lead to potentially unstable operation. With the expanding use of digital processors, throughput delays can occur in manual control systems in a variety of ways ...
Allen, R. W., Dimarco, R. J.
core +1 more source
Analysis Framework for Opportunistic Spectrum OFDMA and its Application to the IEEE 802.22 Standard
, 2012 We present an analytical model that enables throughput evaluation of Opportunistic Spectrum Orthogonal Frequency Division Multiple Access (OS-OFDMA) networks.
Grønsund, Pål +3 more
core +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Listen-and-Talk: Protocol Design and Analysis for Full-duplex Cognitive Radio Networks
, 2016 In traditional cognitive radio networks, secondary users (SUs) typically access the spectrum of primary users (PUs) by a two-stage "listen-before-talk" (LBT) protocol, i.e., SUs sense the spectrum holes in the first stage before transmitting in the ...
Han, Zhu +3 more
core +2 more sources
Assessing new sensor‐based volume measurement methods for high‐throughput bulk density estimation in the field under various soil conditions [PDF]
, 2021 Guillaume Coulouma +3 more
openalex +1 more source