Results 141 to 150 of about 127,095 (220)

Compartmentalized thymidine phosphorylation by mitochondrial nucleotide kinases TK2 and CMPK2. [PDF]

J Biol Chem
Ward AS, Kamath VG, Hsiung CH, Lizenby ZJ, Gillish AG, Kohtz DS, McKee EE.   +6 more
europepmc   +1 more source

eMap 2.0: A Web‐Based Platform for Identifying electron Transfer Pathways in Proteins and Protein Families

WIREs Computational Molecular Science, Volume 16, Issue 2, March/April 2026.
In this review, we present eMap 2.0, a web‐based platform for analyzing electron transfer pathways in proteins. We highlight representative applications of eMap, including its use in characterizing electron transfer within individual proteins and in revealing shared electron transfer pathways across protein families.
James R. Gayvert, Alyssa J. Kranc, Ruslan N. Tazhigulov, Ksenia B. Bravaya   +3 more
wiley   +1 more source

Response of <i>Escherichia coli</i> chemotaxis pathway to pyrimidine deoxyribonucleosides. [PDF]

Microbiol Spectr
Shah M, Xu W, Sourjik V.
europepmc   +1 more source

Cellular Stress, Inflammation and Barrier Damage in Gut Epithelial Cells Caused by Aspartame

Allergy, Volume 81, Issue 3, Page 884-901, March 2026.
This study shows that aspartame, at dietary‐relevant doses, induces cytotoxicity, cellular distress associated with endoplasmic reticulum stress, oxidative stress, DNA replication and repair mechanism disturbance culminating in epithelial barrier damage.
Yagiz Pat, Duygu Yazici, Can Zeyneloglu, Huseyn Babayev, Sena Ardicli, Asuncion Garci‐Sanchez, Xiangting Bu, Anja Heider, Oliva Giannelli Viscardi, Lihong Chang, Sheri Simmons, Anthony Almada, Christine Avena, Tye Jensen, Raja Dhir, Ismail Ogulur, Cezmi A. Akdis   +16 more
wiley   +1 more source

Harnessing nucleotide metabolism to control glycosylase base editing outcomes. [PDF]

Theranostics
Tao R, Li M, Fei J, Tang M, Yang Z, Hu Y, Jiao Y, Hu Z, Yao S.   +8 more
europepmc   +1 more source

Mouse genome engineering uncovers 18 genes dispensable for male reproduction

Andrology, Volume 14, Issue 3, Page 833-846, March 2026.
Abstract Background Male infertility is an intricate multifactorial disease involving the interplay between genetic and environmental factors. Genetic anomalies account for more than 15% of all male infertility cases; however, diagnosing them exhibits enormous challenges due to variable symptomatic presentations and limited knowledge of gene functions.
Hsin‐Yi Chang, Yonggang Lu, Kaito Yamamoto, Jiang Sun, Keisuke Shimada, Yuki Hiradate, Yoshitaka Fujihara, Masahito Ikawa   +7 more
wiley   +1 more source

Real-World Plasma Thymidine Kinase Activity in High-Risk and Metastatic Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Breast Cancer Treated With Cyclin-Dependent Kinase 4/6 Inhibitors. [PDF]

JCO Precis Oncol
O'Connor TN, Schultz E, Kabraji S, Levine E, Williams AJ, Knudsen ES, Witkiewicz AK.   +6 more
europepmc   +1 more source

Managing the Complex Intersection Between Substance Use Disorders and Infectious Diseases

JACCP: JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY, Volume 9, Issue 3, March 2026.
Karissa Chow, Amanda Binkley, Jessica Meisner, Samantha Huo, Matthew Hinton   +4 more
wiley   +1 more source

Insights Into Gut Barrier Dysfunction and Metabolic Alterations in Mycophenolate‐Induced Enteropathy

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 3, March 2026.
ABSTRACT Mycophenolic acid (MPA) is a widely used immunosuppressant whose use is often limited by gastrointestinal toxicity. Gut bacterial hydrolysis of liver‐derived MPA glucuronides increases local exposure to MPA, potentially impairing epithelial barrier function and cellular metabolism.
Clarisse Brossier, François‐Ludovic Sauvage, Christel Valencia‐Schmitt, Valérie Calco, Pascal Villa, Pierre Marquet, Roland Lawson   +6 more
wiley   +1 more source

Single-molecule tracking of DNMT1 in living cells reveals its cell cycle dynamics and its redistribution upon drug treatment. [PDF]

Nucleic Acids Res
Lee ES, Tommer ER, Rothman PB, Middleton SV, Youmans DT, Cech TR.   +5 more
europepmc   +1 more source