Results 1 to 10 of about 130,672 (308)

Structural dynamics of tight junctions modulate the properties of the epithelial barrier.

PLoS ONE, 2019
Tight junctions are dynamic structures that are crucial in establishing the diffusion and electrical barrier of epithelial monolayers. Dysfunctions in the tight junctions can impede this barrier function and lead to many pathological conditions ...
Aapo Tervonen, Teemu O Ihalainen, Soile Nymark, Jari Hyttinen   +3 more
doaj   +3 more sources

Impact of residual feed intake on jejunal tight junction morphology and gene expression in slow-growing Korat chickens [PDF]

Poultry Science
Improving feed efficiency (FE) in Korat chickens (KRC), a Thai slow-growing breed, is essential for reducing production costs. This study aimed to investigate gene and protein expression related to oxidative phosphorylation and tight junction pathways ...
Sukritta Kongthungmon, Saknarin Pengsanthia, Boonyarit Kamkrathok, Pramin Kaewsatuan, Wittawat Molee, Amonrat Molee   +5 more
doaj   +2 more sources

Probiotics and the intestinal tight junction barrier function. [PDF]

Front Cell Dev Biol
Ferris MM, Subitoni Antonio L, Al-Sadi R.   +2 more
europepmc   +2 more sources

A Review of a Breakdown in the Barrier: Tight Junction Dysfunction in Dental Diseases. [PDF]

Clin Cosmet Investig Dent
Do TT, Nguyen VT, Nguyen NTN, Duong KTT, Nguyen TTM, Le DNT, Nguyen TH.   +6 more
europepmc   +3 more sources

Ginsenoside Rg1 Mitigates Porcine Intestinal Tight Junction Disruptions Induced by LPS through the p38 MAPK/NLRP3 Inflammasome Pathway

Toxics, 2022
Inflammation leads to porcine tight junction disruption of small intestinal epithelial cells, resulting in intestinal dysfunction. Herein, we established lipopolysaccharide (LPS)-induced in-vivo and in-vitro inflammatory models. The results revealed that
Jian Kang, Yanhong Zhou, Chunyang Zhu, Tian Ren, Yong Zhang, Longfei Xiao, Binghu Fang   +6 more
doaj   +1 more source

Structure, Function, and Regulation of the Blood-Brain Barrier Tight Junction in Central Nervous System Disorders

Frontiers in Physiology, 2020
The blood-brain barrier (BBB) allows the brain to selectively import nutrients and energy critical to neuronal function while simultaneously excluding neurotoxic substances from the peripheral circulation.
Jeffrey J. Lochhead, Junzhi Yang, Patrick T. Ronaldson, Thomas P. Davis   +3 more
doaj   +1 more source

20 kDa isoform of connexin-43 augments spatial reorganization of the brain endothelial junctional complex and lesion leakage in cerebral cavernous malformation type-3

Neurobiology of Disease, 2023
Cerebral cavernous malformation type-3 (CCM3) is a type of brain vascular malformation caused by mutations in programmed cell death protein-10 (PDCD10).
Chelsea M. Phillips, Allison M. Johnson, Svetlana M. Stamatovic, Richard F. Keep, Anuska V. Andjelkovic   +4 more
doaj   +1 more source

STAT3 pathway is involved in interleukin-22 promoting expression of tight junction protein in human colorectal cancer cell line HT29 [PDF]

Jichu yixue yu linchuang, 2021
Objective To investigate the effect of interleukin-22(IL-22) on intestinal epithelial barrier tight junction and its mechanism. Methods Human colon cancer HT29 cells were divided into control group, IL-22 group(100 ng/mL), FLLL32 group(pretreatment ...
SONG Qian, HUANG Xue, QIN Meng-bin, ZHANG Jun-hong, JING Jie, LUO Yi-hua, LI Yu-xin
doaj  

Astrocytes and pericytes attenuate severely injured patient plasma mediated expression of tight junction proteins in endothelial cells.

PLoS ONE, 2022
Blood Brain Barrier (BBB) breakdown is a secondary form of brain injury which has yet to be fully elucidated mechanistically. Existing research suggests that breakdown of tight junction proteins between endothelial cells is a primary driver of increased ...
Preston Stafford, Sanchayita Mitra, Margot Debot, Patrick Lutz, Arthur Stem, Jamie Hadley, Patrick Hom, Terry R Schaid, Mitchell J Cohen   +8 more
doaj   +1 more source

ZO-1 Guides Tight Junction Assembly and Epithelial Morphogenesis via Cytoskeletal Tension-Dependent and -Independent Functions

Cells, 2022
Formation and maintenance of tissue barriers require the coordination of cell mechanics and cell–cell junction assembly. Here, we combined methods to modulate ECM stiffness and to measure mechanical forces on adhesion complexes to investigate how tight ...
Alexis J. Haas, Ceniz Zihni, Susanne M. Krug, Riccardo Maraspini, Tetsuhisa Otani, Mikio Furuse, Alf Honigmann, Maria S. Balda, Karl Matter   +8 more
doaj   +1 more source