Results 11 to 20 of about 130,672 (308)
Progress in Biophysics and Molecular Biology, 2003 A fundamental function of epithelia and endothelia is to separate different compartments within the organism and to regulate the exchange of substances between them. The tight junction (TJ) constitutes the barrier both to the passage of ions and molecules through the paracellular pathway and to the movement of proteins and lipids between the apical and
L, González-Mariscal +3 more
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Biology Direct, 2006 Background Zonula occludens, also known as the tight junction, is a specialized cell-cell interaction characterized by membrane "kisses" between epithelial cells.
Tang Vivian W
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Butyrate modifies intestinal barrier function in IPEC-J2 cells through a selective upregulation of tight junction proteins and activation of the Akt signaling pathway. [PDF]
PLoS ONE, 2017 The intestinal epithelial barrier, composed of epithelial cells, tight junction proteins and intestinal secretions, prevents passage of luminal substances and antigens through the paracellular space.
Hui Yan, Kolapo M Ajuwon
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Nature Communications, 2017 Determination of apical tension, fluidity, and intercellular adhesive forces in an epithelial monolayer are currently disruptive. Here the authors present a method using acoustic force microscopy to measure changes in these parameters upon tight junction
Alexander X. Cartagena-Rivera +3 more
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Proteomic analysis of proteins surrounding occludin and claudin-4 reveals their proximity to signaling and trafficking networks. [PDF]
PLoS ONE, 2015 Tight junctions are complex membrane structures that regulate paracellular movement of material across epithelia and play a role in cell polarity, signaling and cytoskeletal organization.
Karin Fredriksson +5 more
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Peripheral Nerve Injury Induces Dynamic Changes of Tight Junction Components
Frontiers in Physiology, 2018 Tight junctions seal off physical barriers, regulate fluid and solute flow, and protect the endoneurial microenvironment of the peripheral nervous system. Physical barriers in the peripheral nervous system were disrupted after nerve injury.
Xinghui Wang +8 more
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Cell Reports, 2017 Lymphocytes cross vascular boundaries via either disrupted tight junctions (TJs) or caveolae to induce tissue inflammation. In the CNS, Th17 lymphocytes cross the blood-brain barrier (BBB) before Th1 cells; yet this differential crossing is poorly ...
Sarah E. Lutz +7 more
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Sorbin and SH3 domain-containing protein 2 (SORBS2) is a component of the acto-myosin ring at the apical junctional complex in epithelial cells. [PDF]
PLoS ONE, 2017 SORBS2 is a scaffolding protein associated with Abl/Arg non-receptor tyrosine kinase pathways and is known to interact with actin and several other cytoskeletal proteins in various cell types.
Karin Fredriksson-Lidman +3 more
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Molecules, 2023 Inflammation of the GI tract leads to compromised epithelial barrier integrity, which increases intestine permeability. A compromised intestinal barrier is a critical event that leads to microbe entry and promotes inflammatory responses.
Vishnu Raj +7 more
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Journal of Inflammation Research, 2021 Dong Zhang,1 Jin-tao Zhang,1 Yun Pan,1 Xiao-fei Liu,1 Jia-wei Xu,2 Wen-jing Cui,1 Xin-rui Qiao,1 Liang Dong1,2 1Department of Respiratory, Shandong Qianfoshan Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People’s Republic of China ...
Zhang D +7 more
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