Results 241 to 250 of about 196,709 (295)

Effect of Implementing a Dashboard With or Without a Best Practice Alert on HLA‐B*58:01 Testing Rates Among Allopurinol Users at VA Medical Centers

open access: yesArthritis Care &Research, EarlyView.
Objective The American College of Rheumatology recommends HLA‐B*58:01 allele testing before the initiation of allopurinol, specifically among Asian and African American/Black patients, due to their increased risk for severe hypersensitivity reactions. However, testing rates remain low at many health care facilities.
Abimbola Fadairo‐Azinge   +6 more
wiley   +1 more source

Altered Expression of Intestinal Tight Junctions in Patients with Chronic Kidney Disease: A Pathogenetic Mechanism of Intestinal Hyperpermeability. [PDF]

open access: yesBiomedicines
Georgopoulou GA   +12 more
europepmc   +1 more source

Tight Junctions and Cell Polarity

Annual Review of Cell and Developmental Biology, 2006
The tight junction is an intracellular junctional structure that mediates adhesion between epithelial cells and is required for epithelial cell function. Tight junctions control paracellular permeability across epithelial cell sheets and also serve as a barrier to intramembrane diffusion of components between a cell's apical and basolateral membrane ...
Shin, K, Fogg, VC, Margolis, B
openaire   +5 more sources

Tight junctions

Current Biology, 1998
ABSTRACT Tight junctions are the most apical intercellular junctions of epithelial and endothelial cells and create a regulatable semipermeable diffusion barrier between individual cells. On a cellular level, they form an intramembrane diffusion fence that restricts the intermixing of apical and basolateral membrane components.
Maria S, Balda, Karl, Matter
openaire   +3 more sources

Epithelial Tight Junctions

American Review of Respiratory Disease, 1988
Epithelial cells differentiate by polarizing into an apical and a basolateral domain and by forming tight junctions (TJ) that control permeation through the paracellular route. The molecular nature of this structure, as well as the processes of assembly, sealing, and regulation, are not yet fully understood.
M, Cereijido   +2 more
openaire   +2 more sources

Tight Junctions

Annals of the New York Academy of Sciences, 2009
Tight junctions of epithelial and endothelial cells form selective barriers that regulate paracellular transport of solutes, immune cells, and drugs. Tight junctions consist of proteins that physically “seal” the tight junction but also form channels that allow for permeation between the cells, resulting in epithelial surfaces of different tightness ...
Jörg‐Dieter Schulzke, Michael Fromm
openaire   +1 more source

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