Results 81 to 90 of about 27,271 (263)

Beneficial autoimmunity at body surfaces – immune surveillance and rapid type 2 immunity regulate tissue homeostasis and cancer [PDF]

, 2014
Epithelial cells line body surface tissues and provide a physicochemical barrier to the external environment. Frequent microbial and non-microbial challenges such as those imposed by mechanical disruption, injury or exposure to noxious environmental ...
Agrawal, Aguado, Al-Shami, Allakhverdi, Angkasekwinai, Arwert, Balkwill, Bas, Björkström, Blais, Boyden, Briot, Bryson, Burnet, Burnet, Cella, Cerwenka, Champsaur, Chan, Chao, Chavanas, Chen, Chen, Cheroutre, Conticello, Coussens, Culig, Dalton, Dearman, Deleuran, Demehri, DePinho, Devey, Di Piazza, Dighe, Dunham, Dunn, Dvorak, Ehrlich, Eisenbarth, Ellyard, Engkilde, Eyerich, Farhadi, Felices, Fort, Fritz, Fujisawa, Fukuyama, Furmanski, Fux, Gause, Gebhardt, Giangreco, Girardi, Girardi, Girardi, Golumbek, Gregory, Groh, Gutierrez, Hallett, Hammad, Hams, Harris, Hayday, Heneghan, Hock, Hueber, Humphreys, Imai, Indra, Jackson, Jameson, Jameson, Jensen-Jarolim, Jerde, Jiang, Jiang, Josephs, Jotwani, Jovanovic, Jovanovic, Jung, Kaplan, Karagiannis, Kim, Komai-Koma, Kool, Kool, Kouzaki, Kuroda, Lebel-Binay, Lee, Lindelof, Lodoen, Ma, Magalhaes, Magalhaes, Marichal, Marichal, Matsuda, Matzinger, McCoy, McWhorter, Meehan, Metz, Mishra, Moghaddam, Monticelli, Nestle, Nigro, Obiri, Oh, Okumura, Olver, Ortiz-Urda, Owyang, Palm, Palm, Park, Pastorelli, Pearce, Pedroza-Gonzalez, Pericle, Profet, Qi, Ramsbottom, Raulet, Reali, Renard, Rittmeyer, Rodolfo, Rosenberg, Rölle, Saenz, Sagiv, Salgame, Salimi, Schmidt, Schmitz, Schneider, Schonthaler, Senovilla, Shankaran, Sharp, Sherman, Shi, Shibuya, Simson, Skinnider, Smyth, Soriani, South, Strid, Strid, Strid, Suárez-Alvarez, Swamy, Takahashi, Takai, Tan, Tang, Thomas, Traidl-Hoffmann, Turchinovich, Ullrich, Van Belle, Van Hemelrijck, Vantourout, Verdino, Vernersson, Vesely, Villarreal, Walley, Walter, Wang, Wen, Wen, Wilson, Witherden, Witherden, Wood, Yanaba, Yin, Yoo, Zaiss, Zaph, Zaph, Ziegler, Zitvogel   +190 more
core   +2 more sources

Transcriptome dynamics of CD4⁺ T cells during malaria maps gradual transit from effector to memory [PDF]

, 2020
The dynamics of CD4⁺ T cell memory development remain to be examined at genome scale. In malaria-endemic regions, antimalarial chemoprevention protects long after its cessation and associates with effects on CD4⁺ T cells.
Belz, Gabrielle T., Bramhall, Michael, Chen, Xi, Clarke, Lachlan S., Davenport, Miles P., Engel, Jessica A., Engwerda, Christian R., Haldar, Rohit N., Haque, Ashraful, James, Kylie R., Khoury, David S., Koufariotis, Lambros T., Lane, Steven W., Lansink, Lianne I. M., Laohamonthonkul, Pawat, Lee, Hyun Jae, Lönnberg, Tapio, Moreira, Marcela L., Pernold, Clara P. S., Soon, Megan S. F., Straube, Jasmin, Svensson, Valentine, Teichmann, Sarah A., Thomas, Bryce S., Williams, Cameron G., Wood, Scott   +25 more
core   +2 more sources

TriCON: A Carbon‐Based Triple‐Modal Nanoplatform for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
We developed TriCON, a triple‐modality nanotherapeutic platform, to treat pancreatic ductal adenocarcinoma (PDAC) by synergizing gene editing, chemotherapy, and immunotherapy. TriCON utilizes CRISPR/Cas9 to target the poliovirus receptor (PVR), combined with nano‐encapsulated doxorubicin and checkpoint blockade. This approach achieved significant tumor
Xinyu Peng, Jiaxing Huang, Shengnan Lv, Jian Zhang, Liangliang Zhang, Huan Liu, Yan Liu, Zhen‐An Qiao, Feng Wei, Bao‐Lian Su   +9 more
wiley   +1 more source

Checkpoint inhibitors: What gastroenterologists need to know. [PDF]

, 2018
Checkpoint inhibitors are increasingly being used in clinical practice. They can cause various gastrointestinal, hepatic and pancreatic side effects. As these side effects can be serious, appropriate management is essential.
Ahmed, Monjur
core   +1 more source

TIGIT is a key inhibitory checkpoint receptor in lymphoma

Journal for ImmunoTherapy of Cancer, 2023
Background PD-1 checkpoint blockade therapy (CBT) has greatly benefited patients with select solid tumors and lymphomas but has limited efficacy against diffuse large B-cell lymphoma (DLBCL). Because numerous inhibitory checkpoint receptors have been implicated in driving tumor-specific T cell dysfunction, we ...
James Godfrey, Xiufen Chen, Nicole Sunseri, Alan Cooper, Jovian Yu, Arina Varlamova, Dmitry Zarubin, Yuriy Popov, Connor Jacobson, Ekaterina Postovalova, Zhongmin Xiang, Krystle Nomie, Aleksander Bagaev, Girish Venkataraman, Yuanyuan Zha, Sravya Tumuluru, Sonali M Smith, Justin P Kline   +17 more
openaire   +3 more sources

IL4I1⁺ Macrophages and TDO2⁺ Myofibroblasts Drive AhR‐Mediated Immunosuppression and Ferroptosis Resistance in Solid Predominant Lung Adenocarcinoma

Advanced Science, EarlyView.
Solid predominant lung adenocarcinoma exhibits an immune‐excluded, ferroptosis‐resistant niche enriched with IL4I1⁺ TAMs and TDO2⁺ myCAFs. Spatial and multi‐omics analyses reveal AhR‐driven crosstalk that promotes T cell exhaustion and therapy resistance. Blocking AhR with CH‐223191 restores ferroptosis sensitivity, and its combination with ferroptosis
Zhaoxuan Wang, Weijiao Xu, Lei Zhao, Lin Zhong, Wendan Yu, Shengmin Wang, Lu Sun, Tao Guo, Fengzhou Li, Zhuoshi Li, Lei Fang, Shiqing Wang, Guohui Zhang, Guoqing Xue, Wei Guo, Shilei Zhao, Chundong Gu   +16 more
wiley   +1 more source

Combining TIGIT blockade with IL‐15 stimulation is a promising immunotherapy strategy for lung adenocarcinoma

Clinical and Translational Medicine
Background T‐cell immunoglobulin and immunoreceptor tyrosine‐based inhibitory motif domain (TIGIT) is an immune checkpoint molecule that suppresses CD8+ T‐cell function in cancer.
Baohong Luo, Yu Sun, Qinru Zhan, Yuting Luo, Yu Chen, Tongze Fu, Tiantian Yang, Lijuan Ren, Zhongpeng Xie, Xiaohua Situ, Bixia Liu, Kejing Tang, Zunfu Ke   +12 more
doaj   +1 more source

Combined Photothermal and mTOR‐Targeted Therapy Overcomes Immune Evasion and Enhances Checkpoint Blockade Efficacy in Metastatic Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study reveals that photothermal therapy, while inducing immunogenic cell death in triple‐negative breast cancer, paradoxically activates the oncogenic mTOR pathway to drive immune evasion. To counter this, a smart nanocomposite is engineered to co‐deliver localized hyperthermia and mTOR inhibition.
Yujie Zhao, Jing Yu, Xin Wang, Xu Liu, Fengli Zuo, Tianyue Xu, Leyi Tang, Ling Xiong, Li Li, Huifang Li, Xiaoting Chen, Guang Yang, Jing Jing, Xiaowei Liu   +13 more
wiley   +1 more source

Potential effect of tumor-specific Treg-targeted antibodies in the treatment of human cancers: A bioinformatics analysis

OncoImmunology, 2018
One of the mechanisms of tumor rejection in immune-modulatory treatments is antibody-dependent cell-mediated cytotoxicity (ADCC) of regulatory T cells (Tregs) that infiltrate tumors in which cells expressing activating Fcγ receptors (FcγRs) are present ...
Luigi Cari, Giuseppe Nocentini, Graziella Migliorati, Carlo Riccardi   +3 more
doaj   +1 more source

Moving forward to address key unanswered questions on targeting PD-1/PD-L1 in cancer: limitations in preclinical models and the need to incorporate human modifying factors. [PDF]

, 2019
The tremendous clinical success of immune checkpoint inhibition (ICI), particularly targeting the programmed cell death protein 1 (PD-1)/programmed death-ligand 1/2 (PD-L1/2) pathway, has resulted in application to multiple cancers, as a monotherapy and ...
Le, Catherine T, Murphy, William J
core   +1 more source