Effects of Separate and Concomitant TLR-2 and TLR-4 Activation in Peripheral Blood Mononuclear Cells of Newborn and Adult Horses. [PDF]
PLoS ONE, 2013 Deficient innate and adaptive immune responses cause newborn mammals to be more susceptible to bacterial infections than adult individuals. Toll-like receptors (TLRs) are known to play a pivotal role in bacterial recognition and subsequent immune ...
Johannes Cornelis Vendrig +2 more
doaj +13 more sources
Randomized controlled trial of vitamin d supplementation on toll-like receptor-2 (tlr-2) and toll-like receptor-4 (tlr-4) in tuberculosis spondylitis patients [PDF]
Journal of Orthopaedic Surgery and Research, 2023 Background Tuberculosis spondylitis accounts for approximately 50% of all cases of skeletal tuberculosis. Vitamin D plays a role in the immune system. Vitamin D helps in the activation of TLR-2 and TLR-4, which play a role in the process of tuberculosis ...
Jainal Arifin +5 more
doaj +2 more sources
Fonsecaeapedrosoi Conidia and Hyphae Activate Neutrophils Distinctly: Requirement of TLR-2 and TLR-4 in Neutrophil Effector Functions [PDF]
Frontiers in Immunology, 2020 Chromoblastomycosis is a chronic and progressive subcutaneous mycosis caused mainly by the fungus Fonsecaea pedrosoi. The infection is characterized by erythematous papules and histological sections demonstrating an external layer of fibrous tissue and ...
Leandro Carvalho Dantas Breda +11 more
doaj +2 more sources
CP91110P: A Computationally Designed Multi-Epitope Vaccine Candidate for Tuberculosis via TLR-2/4 Synergistic Immunomodulation [PDF]
BiologyBackground: Tuberculosis (TB) remains a global health priority, with current interventions like the Bacille Calmette–Guérin (BCG) vaccine lacking efficacy against latent infection and drug-resistant strains.
Yajing An +9 more
doaj +2 more sources
Gardnerella vaginalis induces matrix metalloproteinases in the cervicovaginal epithelium through TLR-2 activation. [PDF]
J Reprod Immunol, 2022 Lactobacillus-deficient cervicovaginal microbiota, including Gardnerella vaginalis, are implicated in cervical remodeling and preterm birth. Mechanisms by which microbes drives outcomes are not fully elucidated. We hypothesize that Gardnerella vaginalis induces matrix metalloproteinases through TLR-2, leading to epithelial barrier dysfunction and ...
Gerson KD +5 more
europepmc +3 more sources
Effects of toll like receptor 4 (TLR4) and toll like receptor 2 (TLR 2) gene polymorphisms on clinical outcomes in acute non-biliary pancreatitis patients [PDF]
Frontiers in ImmunologyIntroductionIn this retrospective study, it was aimed to evaluate effects of Toll Like Receptor 4 (TLR4) and Toll Like Receptor 2 (TLR 2) gene polymorphisms on clinical outcomes in acute non-biliary pancreatitis patients.MethodsA total of 108 acute non ...
Ender Anılır +2 more
doaj +2 more sources
Overexpression of proinflammatory TLR-2-signalling lipoproteins in hypervirulent mycobacterial variants [PDF]
Cellular Microbiology, 2011 Changes in the cell envelope composition of mycobacteria cause major changes in cytokine profiles of infected antigen presenting cells. We describe here the modulation of inflammatory responses by Mycobacterium abscessus, an emerging pathogen in cystic fibrosis. M. abscessus is able to switch from a smooth (S) to a rough (R) morphotype by the loss of a
Anne-Laure Roux +2 more
exaly +5 more sources
Induction of TLR-2 and TLR-5 Expression by Helicobacter pylori Switches cagPAI-Dependent Signalling Leading to the Secretion of IL-8 and TNF-α [PDF]
PLoS ONE, 2011 Helicobacter pylori is the causative agent for developing gastritis, gastric ulcer, and even gastric cancer. Virulent strains carry the cag pathogenicity island (cagPAI) encoding a type-IV secretion system (T4SS) for injecting the CagA protein.
Joseph V Madassery, Steffen Backert
exaly +2 more sources
Hyperresponsiveness of Corticoid-Resistant Th17/Tc-17 Cells to TLR-2 and TLR-4 Ligands is a Feature of Multiple Sclerosis Patients at Higher Risk of Therapy Failure [PDF]
Journal of Inflammation ResearchJoana Hygino,1,* Marisa C Sales,2,* Priscila M Sacramento,1 Taissa M Kasahara,3 Júlio César Costa da Silva,3 Rafaela Bilhão,3 Regis M Andrade,4 Cláudia Cristina Ferreira Vasconcelos,1 Cleonice AM Bento1,3– 5 1Post-Graduate Program in Neurology ...
Hygino J +8 more
doaj +2 more sources
Toll-Like Receptor 2 (TLR-2) Gene Polymorphisms in Type 2 Diabetes Mellitus. [PDF]
Cell J, 2019 Innate immunity factors are associated with type 2 diabetes (T2DM) and its complications. Therefore, T2DM has been suggested to be an immune-dependent disease. Elevated fasting glucose level and higher concentrations of innate immunity soluble molecules are not only related with insulin resistance, but inflammation is also an important factor in beta ...
Ermiş Karaali Z +4 more
europepmc +4 more sources