Results 91 to 100 of about 148,086 (284)
Toll-like receptor-2 deficiency enhances non-alcoholic steatohepatitis
BMC Gastroenterology, 2010 Background Previously we reported that mice deficient in toll-like receptor 4 (TLR-4) signalling were protected from diet-induced non-alcoholic steatohepatitis (NASH).
Brady Kristen +6 more
doaj +1 more source
IgA-enhancing effects of membrane vesicles derived from Lactobacillus sakei subsp. sakei NBRC15893 [PDF]
, 2018 Immunoglobulin (Ig) A in the mucus of the intestinal tract plays an important role in preventing the invasion of pathogenic microorganisms and regulating the composition of the gut microbiota.
Katakura Yoshio +7 more
core +2 more sources
TLR-2 and IL-17A in Chitin-Induced Macrophage Activation and Acute Inflammation [PDF]
The Journal of Immunology, 2008 Abstract Chitin is a ubiquitous polysaccharide in fungi, insects, and parasites. To test the hypothesis that chitin is an important immune modulator, we characterized the ability of chitin fragments to regulate murine macrophage cytokine production in vitro and induce acute inflammation in vivo.
Carla A, Da Silva +4 more
openaire +2 more sources
Matrix Stiffness Governs Fibroblasts’ Regulation of Gingival Immune Homeostasis
Advanced Materials, EarlyView.This study identifies a “mechano‐epigenetic” checkpoint in which matrix stiffness governs the immune responses of gingival fibroblasts. Using biomimetic hydrogels and human gingival explants, the studies revealed that restoring extracellular matrix stiffness actively suppresses inflammation via non‐canonical NF‐κB signaling and DNA methylation ...
Hardik Makkar +5 more
wiley +1 more source
Ex vivo mRNA expression of toll-like receptors during latent tuberculosis infection
BMC Immunology, 2021 Background Understanding immune mechanisms, particularly the role of innate immune markers during latent TB infection remains elusive. The main objective of this study was to evaluate mRNA gene expression patterns of toll-like receptors (TLRs) as ...
Birhan Alemnew +6 more
doaj +1 more source
Bacterial extract cantastim activates macrophages via TLR-2.
Roumanian archives of microbiology and immunology, 2011 CANTASTIM is a second generation bacterial immunomodulator. The aim of this study was to examine the mechanism by which bacterial immunomodulator CANTASTIM induces production of inflammatory cytokines in monocytes/macrophages. Proinflammatory cytokines were induced in PMA-differentiated THP-1 cells by stimulation with TLR agonists and CANTASTIM in the ...
Iuliana, Caraş +3 more
openaire +1 more source
Advanced Science, EarlyView.Wedelolactone (WED), a natural TLR2 agonist, promotes neutrophil differentiation and enhances bactericidal function, offering a potential therapeutic strategy for neutropenia. Using a multi‐omics approach, this study reveals that WED activates the TLR2/MEK/ERK pathway, upregulating key transcription factors (PU.1, CEBPβ) to drive neutrophil development.
Long Wang +16 more
wiley +1 more source
Advanced Science, EarlyView.Dendritic cells (DC) vaccine is an important type of vaccines. However, the limited efficacy of DC vaccines hinders their widely application. This study redefines DC vaccines and provides a new DC‐BC vaccine that have much better therapeutic efficacy.
Xiangxiang Xu +11 more
wiley +1 more source
Expression of Toll-like receptors 2 and 4 in gingivitis and chronic periodontitis.
Indian Journal of Dental Research, 2006 Periodontal disease is the major cause of adult tooth loss and is commonly characterized by a chronic inflammation caused by infection by oral bacteria.
Sarah S +3 more
doaj
Indian Journal of Animal Sciences, 2014 Staphylococcus aureus infection of the bovine mammary gland can result in a spectrum of clinical outcomes ranging from acute to chronic and subclinical.
SUSWETA DAS MITRA +7 more
doaj +1 more source