Results 111 to 120 of about 148,086 (284)

Advanced Human Immune Cell‐Organoid Co‐Cultures for Functional Testing of Cancer Nanovaccines

Advanced Science, EarlyView.
Pancreatic ductal adenocarcinoma remains difficult to treat. We establish an organoid–immune co‐culture using patient‐derived organoids and matched T‐cells to assess cancer vaccines. A mesothelin‐targeted nanovaccine activates antigen‐specific T‐cells, increases IFN‐γ, and targets MSLN+ organoids.
Nathalia Ferreira, David Agorku, Andre Rosa, Julia Roosz, Lena Christ, Nicole Anderle, Ajinkya Kulkarni, Abir Hussein, Sana S. Sayedipour, Omar F. Luna, Tobias Legler, Philipp Ströbel, Fernando Albericio, Luis Cruz, Phillipp Beckhove, Peter Loskill, Frauke Alves, M. Andrea Markus, Fernanda Ramos‐Gomes   +18 more
wiley   +1 more source

Immunomodulatory effect of Morinda citrifolia and Andrographis paniculata on expression of toll-like receptors in Nicobari fowl

Indian Journal of Animal Sciences, 2016
This study was conducted to observe the effects of dietary noni and kalmegh supplementation on production performance, immunity and gene expression of toll-like receptors in Nicobari fowl. Supplementation of noni and kalmegh significantly influenced the
JAI SUNDER, T SUJATHA, A RAJA, A KUNDU
doaj   +1 more source

IL‐4/STAT6‐signaling Influences Local Inflammation and Regeneration Processes During Acute Pancreatitis and Promotes Fibrosis by a Direct Activation of Pancreatic Fibroblasts During Chronic Pancreatitis

Advanced Science, EarlyView.
IL‐4/IL‐13/STAT6 signaling plays a crucial for the suppression of pro‐inflammation during acute pancreatitis and supports acinar cell regeneration but has only minor impact on fibrogenesis during chronic form of the disease. IL‐4/IL‐13 induce the expression of certain collagens directly in pancreatic fibroblasts via STAT6 activation, whereas ...
ElSheikh H, Salvers A, Piesker J, Buchholz S, Lange R, Ameling S, Steil L, Hammer E, Homuth G, Völker U, Bröker BM, Weiss FU, Sendler M, Glaubitz J   +13 more
wiley   +1 more source

Polyethylene wear particles induce TLR 2 upregulation in the synovial layer of mice

Journal of Materials Science: Materials in Medicine, 2013
A cellular and receptor mediated response to ultra-high-molecular-weight-polyethylene (UHMWPE) wear particles results in a release of proinflammatory cytokines and induces an inflammatory reaction causing osteolysis in total joint replacement. This investigation offers insight into the toll-like receptor (TLR) mediated activation by polyethylene wear ...
A C, Paulus, J, Frenzel, A, Ficklscherer, B P, Roßbach, C, Melcher, V, Jansson, S, Utzschneider   +6 more
openaire   +2 more sources

Tobacco Smoke Exposure From Prenatal To Adolescent Periods Drives IBD Pathogenesis: Dynamic DNA Methylation Signatures Across Lifespan Stages

Advanced Science, EarlyView.
This study illustrates that maternal smoking during pregnancy (MSDP) is an independent risk factor for IBD in offspring, and DNA methylation serves as a key mechanistic pathway connecting early‐life smoking exposure with IBD risk in offspring. That highlights the urgent need for preventive interventions targeting prospective parents and minors to ...
Han Zhang, Jianhui Zhao, Jie Chen, Xinyi Ma, Siyun Zhou, Alexandra Noble, Rahul Kalla, Judith Wellens, Kun Liu, Evropi Theodoratou, Jack Satsangi, Xue Li   +11 more
wiley   +1 more source

Flow Induced by the Impulsive Motion of an Infinite Flat Plate in a Dusty Gas [PDF]

, 1967
Flow Induced by the Impulsive Motion of an Immite Flat Plate in a Dusty Gas. The problem of flow induced by an infinite flat plate suddenly set into motion parallel to its own plane in an incompressible dusty gas is of considerable physical interest in
Liu, J. T. C.
core  

AXL Promotes Ischemic Myelin Repair Through Alleviating Myelin Debris Deposition and Lipid Droplets Accumulation

Advanced Science, EarlyView.
Microglial AXL drives white matter repair after stroke by orchestrating the cleanup of myelin debris. Mechanistically, AXL signals through EGR1 to boost Smpd1 transcription, regulating sphingolipid metabolism and preventing lipid droplet toxicity. Restoring the pathway with ASM therapy mitigates damage, positioning AXL as a key node for therapeutic ...
Junqiu Jia, Yonghui Gan, Jia Li, Lilin Li, Hailan Meng, Min Sun, Lei Ye, Rui Mao, Xiang Cao, Shengnan Xia, Xinyu Bao, Renyuan Liu, Meijuan Zhang, Yun Xu   +13 more
wiley   +1 more source

ROLE OF INHERENT IMMUNITY AND MICROORGANISMS OF BIOTOPES OF MUCOUS MEMBRANE OF WOMEN’S GENITOURINARY TRACT IN PATHOGENESIS OF CHLAMYDIA INFECTION

Сеченовский вестник, 2010
Aim. Study of Toll-like receptors (TLR) role and microorganisms of bioptopes of genitourinary tract in pathogenesis of genitourinary chlamydiasis.Methods.
M. S. Afanasiev, A. V. Karaulov, V. A. Aleshkin, S. S. Afanasiev, Yu. V. Nesvizhsky, E. A. Voropaeva   +5 more
doaj  

The role of soluble toll-like receptor-2 and 4 in children with pneumonia: a combined analysis of saliva and serum samples

Frontiers in Immunology
BackgroundSince rapid and accurate diagnosis of pneumonia and determination of its severity remain challenging, particularly in childhood, we aimed to evaluate the role of toll-like receptors (TLR) in pneumonia, which has been limited in animal and adult
Ozlem Necipoglu, Osman Oguz Demir, Osman Oguz Demir, Kubra Aykac, Sevilay Karahan, Ali Bulent Cengiz, Malik Aydin, Malik Aydin, Malik Aydin, Yasemin Ozsurekci   +9 more
doaj   +1 more source

Oncolytic Probiotics with Molecular Pili for Solid Tumor Therapy

Advanced Science, EarlyView.
This study identifies Lactobacillus rhamnosus as an intrinsic oncolytic agent that triggers tumor metabolic collapse via calcium‐dependent ROS bursts. By chemically anchoring collagen‐targeting “molecular pili” to the bacterial surface, the engineered non‐transgenic probiotic (LR@MP) achieves targeted colonization and potent solid tumor suppression ...
Haodong Ge, Chengsheng Ding, Xiao Yang, Si Gao, Changjie Yang, Yuchen Hou, Hongye Wang, Linke Bian, Hao Zhong, Yifan Qu, Luyang Zhang, Junjun Ma, Zhengwei Cai, Wenguo Cui, Minhua Zheng   +14 more
wiley   +1 more source