Results 31 to 40 of about 148,086 (284)

Yersinia pseudotuberculosis disrupts intestinal barrier integrity through hematopoietic TLR-2 signaling [PDF]

Journal of Clinical Investigation, 2012
Intestinal barrier function requires intricate cooperation between intestinal epithelial cells and immune cells. Enteropathogens are able to invade the intestinal lymphoid tissue known as Peyer's patches (PPs) and disrupt the integrity of the intestinal barrier. However, the underlying molecular mechanisms of this process are poorly understood. In mice
Camille, Jung, Ulrich, Meinzer, Nicolas, Montcuquet, Elodie, Thachil, Danielle, Château, Raphaële, Thiébaut, Maryline, Roy, Ziad, Alnabhani, Dominique, Berrebi, Monique, Dussaillant, Eric, Pedruzzi, Sophie, Thenet, Nadine, Cerf-Bensussan, Jean-Pierre, Hugot, Frederick, Barreau   +14 more
openaire   +2 more sources

Porphyromonas gingivalis periodontal infection and its putative links with Alzheimer’s disease [PDF]

, 2015
Periodontal disease (PD) and Alzheimer’s disease (AD) are inflammatory conditions affecting the global adult population. In the pathogenesis of PD, subgingival complex bacterial biofilm induces inflammation that leads to connective tissue degradation and
Crean, Stjohn, Harding, Alice, Kesavalu, Lakshmyya, Poole, Sophie, Singhrao, Simarjit Kaur   +4 more
core   +8 more sources

Single nucleotide polymorphisms of TLR-2, TLR-3, TLR-4 and susceptibility to inflammatory diseases of the respiratory tract

Zaporožskij Medicinskij Žurnal, 2018
The aim of the research is to establish an association between Arg753Gln polymorphism of TLR-2 gene, Leu412Phe of TLR-3 gene, Asp299Gly of TLR-4 gene and susceptibility to inflammatory diseases of the upper and lower respiratory tract and the complicated
N. O. Pryimenko, T. M. Kotelevska, H. M. Dubynska, I. P. Kaidashev, K. V. Pikul   +4 more
doaj   +1 more source

Mycobacterium tuberculosisRegulates CD1 Antigen Presentation Pathways through TLR-2 [PDF]

The Journal of Immunology, 2005
AbstractMycobacterium tuberculosis remains a major pathogen of worldwide importance, which releases lipid Ags that are presented to human T cells during the course of tuberculosis infections. Here we report that cellular infection with live M. tuberculosis or exposure to mycobacterial cell wall products converted CD1− myeloid precursors into competent ...
Carme, Roura-Mir, Lisheng, Wang, Tan-Yun, Cheng, Isamu, Matsunaga, Christopher C, Dascher, Stanford L, Peng, Matthew J, Fenton, Carsten, Kirschning, D Branch, Moody   +8 more
openaire   +2 more sources

Zymosan attenuates melanoma growth progression, increases splenocyte proliferation and induces TLR-2/4 and TNF-α expression in mice

Journal of Inflammation, 2018
Background Melanoma is one of the most common types of skin malignancies. Since current therapies are suboptimal, considerable interest has focused on novel natural-based treatments.
Mehdi Taghavi, Esmaeil Mortaz, Alireza Khosravi, Ghasem Vahedi, Gert Folkerts, Mohammad Varahram, Mehdi Kazempour-Dizaji, Johan Garssen, Ian M. Adcock   +8 more
doaj   +1 more source

Aggregatibacter actinomycetemcomitans modulates toll-like receptors 2 and 4 in gingival epithelial cells in experimental periodontitis

Journal of International Clinical Dental Research Organization, 2010
Background: Periodontitis is a common bacterial infection precipitated by exaggerated host responses to the oral microorganisms, As the first cells to encounter the oral pathogens the gingival epithelial cells (GEC) respond via toll-like receptors (TLR ...
Mythily Srinivasan, Krithika N Kodumudi, Dominique M Galli   +2 more
doaj   +1 more source

Toll-like Receptors 2 and 4 and Their Mutations in Patients with Otitis Media and Middle Ear Effusion [PDF]

Clinical and Experimental Otorhinolaryngology, 2008
ObjectivesToll-like receptors (TLRs) detect microbial infections and they can directly induce innate host defense responses. TLR 2 has been shown to be primarily involved in the recognition of peptidoglycans and lipoteichoic acid of gram positive ...
Young Chan Lee, Chul Kim, Ju Sup Shim, Jae Yong Byun, Mun Suh Park, Chang Il Cha, Young Il Kim, Jin Woo Lee, Seung Geun Yeo   +8 more
doaj   +1 more source

Research progress on the signaling pathways involved in the pathogenesis of acne

Pifu-xingbing zhenliaoxue zazhi
Acne is a chronic cutaneous inflammatory disorder of the pilosebaceous units, affecting a large number of adolescents and adults worldwide, and its pathogenesis is still unclear.
LIU Bai, WU Jin
doaj   +1 more source

CD14+ CD15- HLA-DR- myeloid-derived suppressor cells impair antimicrobial responses in patients with acute-on-chronic liver failure. [PDF]

, 2017
OBJECTIVE: Immune paresis in patients with acute-on-chronic liver failure (ACLF) accounts for infection susceptibility and increased mortality. Immunosuppressive mononuclear CD14+HLA-DR- myeloid-derived suppressor cells (M-MDSCs) have recently been ...
Adams, DH, Antoniades, CG, Bernsmeier, C, Brenig, R, Khamri, W, Lebosse, FJ, Nathwani, R, Patel, VC, Pop, OT, Singanayagam, A, Thursz, MR, Tidswell, R, Triantafyllou, E, Wendon, JA, Weston, CJ   +14 more
core   +2 more sources

TLR‐2 agonist enhances the development of autoimmune diabetes

The FASEB Journal, 2008
Toll‐like receptor 2 agonist (TLR2) BLP (bacterial lipoprotein, PAM3CSV‐4) was found to enhance IL‐12 and INF‐α synthesis to ameliorate Th‐2 dependent pathology in experimental asthma and to modulate the functions of CD4 + CD25 + regulatory cells. TLR‐2
Miodrag L Lukic, Eric Mensah‐Brown, Allen Shahin   +2 more
openaire   +1 more source