Results 61 to 70 of about 148,086 (284)

Skin Mast Cells Contribute to Sporothrix schenckii Infection [PDF]

, 2020
Background: Sporothrix schenckii (S. schenckii), a dimorphic fungus, causes sporotrichosis. Mast cells (MCs) have been described to be involved in skin fungal infections. The role of MCs in cutaneous sporotrichosis remains largely unknown. Objectives:
Frischbutter, Stefan, Geng, Peng, Jiao, Qingqing, Li, Ruoyu, Luo, Ying, Maurer, Marcus, Scheffel, Jörg, Wang, Yuhan, Zhao, Zuotao   +8 more
core   +1 more source

Direct TLR-2 Costimulation Unmasks the Proinflammatory Potential of Neonatal CD4+ T Cells [PDF]

The Journal of Immunology, 2016
Abstract Neonatal CD4+ T cells have traditionally been viewed as deficient in their capacity to produce Th1 cytokines in response to polyclonal or Ag-specific stimuli. Thus, defining unique aspects of CD4+ T cell activation and development into Th1 effector cells in neonates is essential to the successful development of novel vaccines ...
Brian D Sinnott, Byung Park, Mardi C Boer, Deborah A Lewinsohn, Christina L Lancioni   +4 more
openaire   +2 more sources

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

Fano and Kondo resonance in electronic current through nanodevices

, 2001
Electronic transport through a quantum dot strongly coupled to electrodes is studied within a model with two conduction channels. It is shown that multiple scattering and interference of transmitted waves through both channels lead to Fano resonance ...
A. C. Hewson, A. Kawabata, A. Schiller, A. Yacoby, A.-P. Jauho, Bogdan R. Bułka, C. Lacroix, D. C. Ralph, D. Goldhaber-Gordon, E. Tekman, H. Haug, J. Göres, J. T. Li, J. U. Nöckel, L. I. Glazman, L. I. Glazman, L. P. Rokhinson, O. Újsághy, Piotr Stefański, S. M. Cronenwett, T. K. Ng, U. Fano, U. Gerland, V. Madhavan, W. G. van der Wiel, W.-D. Schneider, Y. Meir   +26 more
core   +1 more source

TLR 2/1 interaction of pectin depends on its chemical structure and conformation

Carbohydrate Polymers, 2023
Citrus pectins have demonstrated health benefits through direct interaction with Toll-like receptor 2. Methyl-ester distribution patterns over the homogalacturonan were found to contribute to such immunomodulatory activity, therefore molecular interactions with TLR2 were studied.
Jermendi, Éva, Fernández-Lainez, Cynthia, Beukema, Martin, López-Velázquez, Gabriel, van den Berg, Marco A., de Vos, Paul, Schols, Henk A.   +6 more
openaire   +4 more sources

Host‐Directed Biomaterials for Combatting Bloodstream Infections: From Macrocyclic Peptides to Immune‐Activating Cell Backpacks

Advanced Functional Materials, EarlyView.
Bloodstream infections (BSI) are one of the leading causes of mortality and morbidity in both civilian and military populations. This paper summarizes recent progress in novel treatment strategies to manage BSI arising from both bacterial and fungal pathogens using molecules, particles, and materials to elicit host‐directed immunity.
Thomas Thomou, Jagadish Krishnappa, Justin B. Schaal, Prasad Tongaonkar, Dat Q. Tran, Wenchao Gu, Yung‐Fu Chang, Michael E. Selsted, Shaoyi Jiang, Samir Mitragotri, Michael Super, Christopher J. Bettinger   +11 more
wiley   +1 more source

Efficient atomic quantum memory for photonic qubits in cavity QED [PDF]

, 2007
We investigate a scheme of atomic quantum memory to store photonic qubits of polarization in cavity QED. It is observed that the quantum-state swapping between a single-photon pulse and a $ \Lambda $-type atom can be made via scattering in an optical ...
Biswas, Chanelière, Chen, Chou, Cirac, Cirac, Dantan, Duan, Duan, Fiurášek, Fleischhauer, Gardiner, Gea-Banacloche, Guo, Hiroyuki Yamada, Julsgaard, Katsuji Yamamoto, Kimble, Kozhekin, Kraus, Kuzmich, Leung, Ley, Liu, Lukin, Matsukevich, Maître, McKeever, Moiseev, Moiseev, Monroe, Muschik, Opatrný, Parkins, Parkins, Paternostro, Pellizzari, Pittman, Pritchett, Schori, Sherson, van Enk, van Enk, Wang, Yao, Zhou   +45 more
core   +3 more sources

Role of Toll-Like Receptor (TLR) 2 in Experimental Bacillus cereus Endophthalmitis

PLoS ONE, 2011
Bacillus cereus causes a uniquely rapid and blinding intraocular infection, endophthalmitis. B. cereus replicates in the eye, synthesizes numerous toxins, and incites explosive intraocular inflammation. The mechanisms involved in the rapid and explosive intraocular immune response have not been addressed. Because Toll-like receptors (TLRs) are integral
Billy D Novosad, Roger A Astley, Michelle C Callegan   +2 more
openaire   +4 more sources

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

Toll-Like Receptor-1 and Receptor-2 and Beta-Defensin in Postcholecystectomy Bile Duct Injury

Gastroenterology Research and Practice, 2015
Postcholecystectomy bile duct injuries (BDI) produce hepatic cholestasis and cause infection of the biliary tract. The biliary cells participate in secreting cytokines and in expression of immune response receptors.
Alejandra Guillermina Miranda-Díaz, José Manuel Hermosillo-Sandoval, Martha Arisbeth Villanueva-Pérez, Luis Miguel Román-Pintos, Trinidad García-Iglesias, Adolfo Daniel Rodríguez-Carrizalez, Ernesto Germán Cardona-Muñoz   +6 more
doaj   +1 more source