Results 81 to 90 of about 148,086 (284)

Skin-derived dendritic cells acquire and degrade the scrapie agent following in vitro exposure [PDF]

, 2005
The accumulation of the scrapie agent in lymphoid tissues following inoculation via the skin is critical for efficient neuroinvasion, but how the agent is initially transported from the skin to the draining lymph node is not known. Langerhans cells (LCs)
Caughey B, Fraser H, Huang F-P, Kapasi ZF, Meyer RK, Porter DD, Taylor DM, Wright SD, Wykes M, Xu S, Yamada N   +10 more
core   +2 more sources

From RNA to DNA: How Cargo Identity Reprograms Lipid Nanoparticle Architecture and Function

Advanced Healthcare Materials, EarlyView.
The evolution of lipid nanoparticles (LNPs) spans from RNA‐LNPs, used in mRNA vaccines, to DNA‐LNPs, ideal for gene therapies. Emerging bionano architectures, decorated with DNA and plasma proteins, pave the way for advanced DNA‐based therapies that are more stable, targeted, and customizable.
Erica Quagliarini, Daniela Pozzi, Giulio Caracciolo   +2 more
wiley   +1 more source

Acute brucella melitensis M16 infection model in mice treated with tumor necrosis factor-alpha inhibitors [PDF]

, 2015
Introduction: There is limited data in the literature about brucellosis related to an intracellular pathogen and anti-tumor necrosis factor alpha (anti-TNFα) medication.
Akalın, Ş., Demirkan, N., Ergin, Ç., Kutlu, Murat, Sayin-Kutlu, S., Zorbozan, O., Çobankara, V., Şahin, B., Şen-Türk, N.   +8 more
core   +1 more source

Effect of exogenous MCP-1 on TLR-2 neutralized murine macrophages and possible mechanisms of CCR-2/TLR-2 and MCP-1 signalling during Staphylococcus aureus infection

Immunobiology, 2015
It has been reported that Staphylococcus aureus survives within macrophages by hijacking host cell surface Toll-like receptor-2 (TLR-2). Moreover, S. aureus infection induced activation of TLR-2 has been reported to downregulate the expression of CC-chemokine receptor-2 (CCR-2), a receptor essential for binding of chemokines to propagate phagocytosis ...
Biswadev, Bishayi, Debasish, Bandyopadhyay, Arnab, Majhi, Rana, Adhikary   +3 more
openaire   +2 more sources

Probing Cellular Activity Via Charge‐Sensitive Quantum Nanoprobes

Advanced Materials, EarlyView.
A new quantum sensing modality detects shifts in zero‐field splitting caused by charge rearrangement with diamond nanocrystals in response to cellular activity. These electric‐field‐driven effects provide an alternative to temperature‐based interpretations, enabling real‐time, single‐cell readout of inflammation.
Uri Zvi, Shivam Mundhra, David Ovetsky, Qing Chen, Aidan R. Jones, Stella Wang, Maria J. Román‐Vazquez, Marie Kim, Udoka M. Ibeh, Michele Ferro, Kunle Odunsi, Marina C. Garassino, Michael E. Flatté, Melody A. Swartz, Denis R. Candido, Aaron Esser‐Kahn, Peter C. Maurer   +16 more
wiley   +1 more source

Patterns of milk productivity associated with biochemical parameters and expressions of the HSPs and Toll Like genes in dairy buffaloes

Medicina Veterinária
The aim of this study was to verify milk productivity associated with biochemical parameters and expression of stress marker genes (HSP70, HSP90?, HSP90?) and immunity (TLR-2 and TLR-4) in dairy buffaloes.
Henrique Low Nogueira, Elem Cristina Macedo Barra de Sousa, Cintia Luana Pinheiro Santos, Ednaldo Silva Filho, Priscila Di Paula Bessa Santana   +4 more
doaj   +5 more sources

Placental Trophoblast Responses to Porphyromonas gingivalis Mediated by Toll-like Receptor-2 and -4

Journal of Dentistry Indonesia, 2013
Trophoblast participates in preventing allorecognition and controlling pathogens that compromise fetal wellbeing. Toll-like receptors recognize conserved sequences on the pathogens surface and trigger effector cell functions.
Banun Kusumawardani, Marsetyawan HNE Soesatyo, Djaswadi Dasuki, Widya Asmara   +3 more
doaj   +1 more source

Protein level expression of Toll-like receptors 2, 4 and 9 in renal disease [PDF]

, 2017
Background. Toll-like receptors (TLR) recognize a variety of ligands, including pathogen-associated molecular patterns and link innate and adaptive immunity. Individual receptors can be up-regulated during infection and inflammation.
Batsford, Stephen, Duermueller, Ursula, Hopfer, Helmut, Mihatsch, Michael, Mueller, Christoph, Seemayer, Christian   +5 more
core  

Porphyromonas gingivalis lipopolysaccharide alters atherosclerotic-related gene expression in oxidized low-density-lipoprotein-induced macrophages and foam cells [PDF]

, 2011
The molecular mechanism between atherosclerosis formation and periodontal pathogens is not clear although positive correlation between periodontal infections and cardiovascular diseases has been reported.
de Winther, Demmer, Diya, Fischer, Gamble, Ghosh, Giacona, Gibson, Gitlin, Groeneweg, Janabi, Kleemann, Lalla, Li, Lu, Ma, Majdalawieh, Martin, Mikita, Oram, Qi, Robbesyn, Ross, Zhou   +23 more
core   +2 more sources

Remote‐Controllable Immune‐Priming Spot Formation Via Nanocomplexed Hydrogel‐Assisted Histotripsy: Immunoasis

Advanced Materials, EarlyView.
A novel immunotherapeutic strategy combines injectable, adjuvant‐loaded hydrogels with externally controlled histotripsy to create immune‐priming sites within tumors. This approach generates millimeter‐sized immune‐activated lesions with flexible, patient‐tailored treatment scheduling, enabling precise immune activation through tumor ablation‐mediated ...
Sung Hoon Kim, Wonseok Choi, Yurim Kim, Hyeongmin Kim, Gu Won Jeong, Hyewon Park, Inchan Youn, Yoon Park, Sungmin Han, Young‐Min Kim   +9 more
wiley   +1 more source