Türk Biyokimya DergisiM2-polarized macrophages and interleukin (IL)-6 significantly alter the tumor microenvironment and promote the malignant behaviors of tumor cells. This study aimed to establish M2-type macrophages from THP-1 cells, which are human leukemia monocytes, and
Jo Wol Soon +10 more
doaj +1 more source
Stigmasterol attenuates atherosclerosis by inhibiting inflammatory signaling and foam cell formation
iMetaOmics, EarlyView.Stigmasterol mitigates atherosclerotic plaque formation by modulating foam cell phenotypic alterations and cholesterol metabolism. Stigmasterol inhibits inflammatory CD86+ macrophage polarization via the NF‐κB/NLRP3 pathway and downregulates CD68 expression in smooth muscle cells (SMCs), contributing to reduced vascular inflammation.
Baiyi Lu +10 more
wiley +1 more source
Evidence of expression of endotoxin receptors CD14, toll-like receptors TLR4 and TLR2 and associated molecule MD-2 and of sensitivity to endotoxin (LPS) in islet beta cells [PDF]
, 2003 Marta Vives‐Pi +8 more
openalex +1 more source
New trend in molecular diagnostics: Insights from the tumor microenvironment
Interdisciplinary Medicine, EarlyView.The graphical abstract outline the key elements in TME‐based molecular diagnostics, including biomarker exploration, diagnostic methods, and diagnostic models. Source: Created with BioRender.com. Abstract Molecular diagnosis has revolutionized cancer precision medicine.
Baiyuan Fan +3 more
wiley +1 more source
Medicine Bulletin, EarlyView.ABSTRACT In multiple sclerosis (MS), demyelination is often accompanied by severe motor and cognitive disability. Remyelination is the process of regenerating new myelin sheath on impaired axons, which is typically carried out by oligodendrocyte precursor cells (OPCs).
Zixin Gao +6 more
wiley +1 more source
Highly purified lipoteichoic acid activates neutrophil granulocytes and delays their spontaneous apoptosis via CD14 and TLR2 [PDF]
, 2003 Sonja Lotz +6 more
openalex +1 more source
Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction
PROTEOMICS, EarlyView.ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella +6 more
wiley +1 more source
Activation of Toll-Like Receptor 2 (TLR2) and TLR4/MD2 by Neisseria Is Independent of Capsule and Lipooligosaccharide (LOS) Sialylation but Varies Widely among LOS from Different Strains [PDF]
, 2003 Alison C. Pridmore +5 more
openalex +1 more source
Mining Alzheimer's Interactomes, Macromolecular Complexes and Pathways for Drug Discovery
PROTEOMICS, EarlyView.ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disorder that leads to dementia. Many cases are diagnosed annually and there is no currently available cure. Understanding the underlying disease biology of AD through the study of molecular networks, particularly by mapping clinical variants to tissue‐specific interactomes and ...
Kalpana Panneerselvam +12 more
wiley +1 more source
Mycobacterial lipoarabinomannan mediates physical interactions between TLR1 and TLR2 to induce signaling [PDF]
, 2003 Richard I. Tapping, Peter S. Tobias
openalex +1 more source