Lactate Secretion by Monocytes as a Determinant of Innate Immune Cell Fitness in Healthy Elderly
Aging Cell, EarlyView.Lactate secretion by monocytes can be used to classify healthy elderly individuals with reduced immune fitness exemplified by hypermetabolic and hyperinflammatory responses. This classification may reflect increased susceptibility to cardiometabolic complications given its link with higher circulating LDL‐c and VEGF levels.
Lisa Smeehuijzen +8 more
wiley +1 more source
Focal Staphylococcus Aureus Septic Arthritis Elicits Age and TLR2-Dependent Periarticular Bone Loss
Journal of Inflammation ResearchMichelle Schultz,1,* Zhicheng Hu,1,2,* Meghshree Deshmukh,1 Petra Henning,3 Ulf H Lerner,3 Majd Mohammad,1 Tao Jin1,4 1Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg,
Schultz M +6 more
doaj
Distinct Roles of IL‐4, IL‐13, and IL‐22 in Human Skin Barrier Dysfunction and Atopic Dermatitis
Allergy, EarlyView.This study reports the distinct effects of IL‐4, IL‐13, and IL‐22 on bio‐stabilized human skin with intact barriers and immune cells. IL‐4, IL‐13, and IL‐22 upregulate inflammatory mediators, disrupt skin barrier integrity, and reciprocally modulate IL‐4Rα and IL‐22Rα1 receptors.
Paolo D'Avino +12 more
wiley +1 more source
Single Cell Analysis Reveals Dynamic Changes of Distinct Cell Populations in Human Nickel Allergy
Allergy, EarlyView.We investigated cell types mediating the early and late inflammatory responses in human Ni2+‐allergy by scRNA‐Seq. Early responsiveness was mainly mediated by TLR4+TAGLN− endothelial cells indirectly activating TLR4−KRT16+ keratinocytes, and CCR7+DCN+ DCs. Late responsiveness was crucially driven by infiltration of KLF2+ central memory T cells and TLR4+
Marc Schmidt +7 more
wiley +1 more source
TLR2 is mobilized into an apical lipid raft receptor complex to signal infection in airway epithelial cells [PDF]
, 2004 Grace Soong +4 more
openalex +1 more source
Clinical &Experimental Ophthalmology, EarlyView.ABSTRACT Background Endophthalmitis requiring multiple ocular tissue sampling for microbiological testing is uncommon and has not been previously studied. This study aims to analyse cases with at least two ocular tissue samplings and testing of different ocular samples against culture yields. Methods A 27‐year prospective observational study using data
Pravena Kumaran +5 more
wiley +1 more source
IL-10 Released by Concomitant TLR2 Stimulation Blocks the Induction of a Subset of Th1 Cytokines That Are Specifically Induced by TLR4 or TLR3 in Human Dendritic Cells [PDF]
, 2004 Fabio Re, Jack L. Strominger
openalex +1 more source
IL-6 and IL-10 Induction from Dendritic Cells in Response to Mycobacterium tuberculosis Is Predominantly Dependent on TLR2-Mediated Recognition [PDF]
, 2004 Sihyug Jang +3 more
openalex +1 more source