Ginsenoside Rg1 attenuates experimental periodontitis via modulating the PI3K/AKT pathway and TLR2 expression. [PDF]
BMC Oral HealthPu Y, Chen L, Wang D, Pan Y, Guo L.
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Antibiotic‐mediated immune modulation in periodontitis
Periodontology 2000, EarlyView.Abstract Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth. Although initiated by dysbiotic microbial communities, its progression is largely driven by the host's uncontrolled inflammatory response. While antibiotics have conventionally been employed in periodontitis therapy for their antimicrobial ...
Lina J. Suárez +6 more
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Development and internal validation of a TLR2-based nomogram for diagnosing pulmonary infection in type 2 diabetes. [PDF]
Front Endocrinol (Lausanne)Ma Y, Qin F.
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Histiocytes: Multifaceted Regulators of Health and Disease
Veterinary Clinical Pathology, EarlyView.ABSTRACT The mononuclear phagocyte system encompasses macrophages, dendritic cells (DCs), and monocytes. Tissue‐resident macrophages and dendritic cells arise during embryogenesis and are replenished either through self‐renewal or by monocytes during inflammation.
Erika J. Gruber
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Bisarylthiourea comprising cycloalkyl-thiophene-3-carboxylate derivatives as potential human toll-like receptor (TLR2) agonists: design, synthesis, and structure-activity relationship enabling the switch from TLR2/1 to TLR2/6 activation. [PDF]
RSC Med ChemChandrakanth M +5 more
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Immune system benefits of pulmonary rehabilitation in chronic obstructive pulmonary disease
Experimental Physiology, EarlyView.Abstract Chronic obstructive pulmonary disease (COPD) is a respiratory disease characterized by pulmonary and systemic inflammation. Inflammatory mediators show relationships with shortness of breath, exercise intolerance and health related quality of life. Pulmonary rehabilitation (PR), a comprehensive education and exercise training programme, is the
Asghar Abbasi +4 more
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Secretome and Pathway Analysis of Stress Induced Disc Degeneration In Vitro
JOR SPINE, Volume 9, Issue 2, June 2026.Integrated secretome and phosphoprotein profiling of human nucleus pulposus cells revealed that IL‐1β and TLR2/6 activation induce a shared degenerative program, defined by consistent upregulation of IL‐6, IL‐8, GRO‐α, ICAM‐1, and MMP‐7 and convergence on NF‐κB/AP‐1 signaling.
Exarchos Kanelis +4 more
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Membrane Vesicles from <i>Lactobacillus acidophilus</i> Promote Superior Cytokine Modulation and Antimicrobial Signaling Compared with Their Whole Cells in RAW 264.7 Macrophages. [PDF]
Int J Mol SciLonngi Sosa CD +10 more
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Biomedical Chromatography, Volume 40, Issue 5, May 2026.ABSTRACT The Copaifera species are traditionally used for their anti‐inflammatory, antiseptic and healing properties. The objective of this study was to compare the chromatographic profiles of seven samples of copaiba oil‐resin with respect to chromatographic and physicochemical properties and to evaluate their biological activities.
Gabriel de A. P. Graça +13 more
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ADSC-derived exosomes inhibit myofibroblast transdifferentiation and attenuate airway stenosis via METTL3-mediated m6A modification of TLR2. [PDF]
Am J Transl ResZhang G, Zheng T, Guo W, Zhuang X.
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