Results 191 to 200 of about 151,127 (263)

Monocyte LOXHD1 and RHOB Expression Predictive of Progressive Systemic Sclerosis–Associated Interstitial Lung Disease

Arthritis Care &Research, Volume 78, Issue 4, Page 456-468, April 2026.
Objective A leading cause of death among patients with scleroderma (SSc), interstitial lung disease (ILD) remains challenging to prognosticate. The discovery of biomarkers that accurately determine which patients would benefit from close monitoring and aggressive therapy would be an essential clinical tool.
Cristina M. Padilla, Robert Lafyatis, Kevin F. Gibson, Christina Morse, Eleanor Valenzi, Xiaoping Chen, Xiaoyun Li, Yanwu Zhao, Yongseok Park, Dana Ascherman, Jonathan Minden, Robyn Domsic, Yingze Zhang, Daniel J. Kass   +13 more
wiley   +1 more source

Computational-experimental study reveals direct target and bioactives of Ajania fruticulosa against NAFLD via TLR2/NF-κB/PPAR-γ signaling. [PDF]

NPJ Sci Food
Chen C, Ma L, Dawuti A, Feng X, Chen S, An X, Bai Y, Zhang T, Aydin M, Kashmiri K, Ma Z, Zhang W, Yaermaimaiti S, Abulizi A.   +13 more
europepmc   +1 more source

Extracellular Vesicles of Streptococcus anginosus Mediate Gastritis via Epithelial Barrier Disruption and Macrophage‐driven Inflammation

Advanced Science, Volume 13, Issue 19, 2 April 2026.
Streptococcus anginosus extracellular vesicles (SA‐EVs) accumulate in gastric tissue, disrupt epithelial tight junctions, and induce gastritis characterized by neutrophil infiltration and elevated cytokines (TNF‐α, IL‐6, IL‐17A). Proteomics identifies TMPC and FBP62 as key SA‐EVs virulence factors; their genetic deletion attenuates inflammation ...
Ying Gong, Lina Duan, Jie Xiao, Yulu Deng, Hongxia Wang, Yajie Zhang, Xiumei Hu, Haifang Wang, Taixue An, Xin Li, Yurong Qiu, Lei Zheng, Haixia Li   +12 more
wiley   +1 more source

Influence of Gut Microbiota on Response to Immune Check Point Inhibitors in MASLD Patients With HCC: Unraveling the Connection

Cancer Medicine, Volume 15, Issue 4, April 2026.
ABSTRACT Immune checkpoint inhibitors (ICIs) have emerged as a promising treatment for various cancers, including advanced hepatocellular carcinoma (HCC). However, a significant proportion of patients with HCC, particularly those with metabolic dysfunction‐associated liver disease (MASLD), exhibit resistance to ICI therapy.
Mazen Elsheikh, Mohamad Ali Ibrahim, Sherry Fares, Megha Bhongade, Karim Adhem, Ximena I. Ramirez‐Morales, Ahmed O. Kaseb, Joseph Petrosino, Manal M. Hassan, Prasun K. Jalal   +9 more
wiley   +1 more source

Protective effect of Zymosan-A against radiation-induced premature ovarian insufficiency in a murine model. [PDF]

iScience
Yu Y, Du J, Li B, Cheng Y, Lin F, Zhou J, Song Y, Liu C, Cai S.   +8 more
europepmc   +1 more source

Periodontitis and extracellular vesicles: Emerging roles in inflammation, tissue destruction and systemic crosstalk

Clinical and Translational Discovery, Volume 6, Issue 2, April 2026.
Extracellular vesicles released from periodontal tissues and pathogens mediate local inflammation and disseminate systemically via the circulation. By transporting regulatory microRNAs and inflammatory cytokines, these vesicles link periodontitis to systemic inflammatory conditions and represent emerging targets for minimally invasive diagnostics and ...
Mai Ahmed, Dada Oluwaseyi Temilola, Mushi Matjila, Manogari Chetty   +3 more
wiley   +1 more source

Overview of the immunomodulatory role of bacterial probiotic-derived peptidoglycan: from molecular insights to therapeutic application. [PDF]

Front Microbiol
Allela OQB, Shareef A, Sameer HN, Yaseen A, Athab ZH, Adil M.   +5 more
europepmc   +1 more source

Prophylactic Inhaled Pattern Recognition Receptor Agonists Reprogram Lung Epithelial Response and Prevent Type 2 Allergic Inflammation

European Journal of Immunology, Volume 56, Issue 4, April 2026.
Inhaled pretreatment of mouse lungs with immunomodulatory Pam2ODN results in lung epithelial cell epigenetic reprogramming that is associated with attenuation of house dust mite extract (HDM)‐induced cDC2s and moDCs expansion in the lung, causing tolerance against HDM sensitization and restricting Th2‐cell‐induced airway eosinophilic allergic ...
Mbaya Ntita, Celine Shuet Lin Kong, Dalia Hassan, Richa Nayak, Jezreel Pantaleón García, Yongxing Wang, Jichao Chen, Scott E. Evans   +7 more
wiley   +1 more source

Differential regulatory mechanisms of gut-derived SCFAs (acetate, propionate, butyrate) on the pulmonary TLR2 signaling pathway and their roles in the inflammatory balance of bacterial pneumonia. [PDF]

Eur J Med Res
Chen H, Xu Y, Qiu J, Guan Z, Yu S, Ding Y.   +5 more
europepmc   +1 more source

Ginkgolide B Alleviates Airway Inflammation in Hyperoxia Lung Injury

Immunity, Inflammation and Disease, Volume 14, Issue 4, April 2026.
ABSTRACT Background Bronchopulmonary dysplasia (BPD) is a chronic lung disease characterized by inflammation, often caused by prolonged hyperoxia exposure in preterm infants. Platelet‐activating factor (PAF) is a potent inflammatory mediator, but its role in BPD is unclear.
Xuesong Wang, Mingwu Chen, Yong Lv, Yue Qi, Dake Huang, ShuShu Wang   +5 more
wiley   +1 more source