Mycobacterial lipoarabinomannan mediates physical interactions between TLR1 and TLR2 to induce signaling [PDF]
, 2003 Richard I. Tapping, Peter S. Tobias
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Macrophage Efferocytosis as a Therapeutic Strategy in Intervertebral Disc Degeneration
Cell Proliferation, EarlyView.Macrophages, integral to degenerated intervertebral discs, play a critical role in disc degeneration. By performing efferocytosis, they clear apoptotic cells. This article explores the process of efferocytosis, its molecular mechanisms, potential therapeutic implications for intervertebral disc degeneration and future strategies for targeted treatments.
Shijie Chen +9 more
wiley +1 more source
TLR2 is mobilized into an apical lipid raft receptor complex to signal infection in airway epithelial cells [PDF]
, 2004 Grace Soong +4 more
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European Journal of Clinical Investigation, EarlyView.In a population of patients with stable CAD, circulating levels of PCSK9 are independently associated with the progression of adverse coronary plaque phenotypes, as assessed by serial coronary computed tomography angiography. At RNA‐seq analysis of whole blood, PCSK9 was linked to the expression of genes involved in the innate‐immune response.
Rosetta Ragusa +7 more
wiley +1 more source
Focal Staphylococcus Aureus Septic Arthritis Elicits Age and TLR2-Dependent Periarticular Bone Loss
Journal of Inflammation ResearchMichelle Schultz,1,* Zhicheng Hu,1,2,* Meghshree Deshmukh,1 Petra Henning,3 Ulf H Lerner,3 Majd Mohammad,1 Tao Jin1,4 1Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg,
Schultz M +6 more
doaj
IL-10 Released by Concomitant TLR2 Stimulation Blocks the Induction of a Subset of Th1 Cytokines That Are Specifically Induced by TLR4 or TLR3 in Human Dendritic Cells [PDF]
, 2004 Fabio Re, Jack L. Strominger
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European Journal of Clinical Investigation, EarlyView.This review outlines the potential role of anti‐GPCR autoantibodies in MASLD/MASH, given their involvement in a wide range of diseases and their possible contribution to MASLD/MASH pathophysiology. We also focused on anti‐ApoA1 autoantibodies, sharing functional features with anti‐GPCR autoantibodies and have been shown to promote liver steatosis in ...
Sabrina Pagano +3 more
wiley +1 more source
IL-6 and IL-10 Induction from Dendritic Cells in Response to Mycobacterium tuberculosis Is Predominantly Dependent on TLR2-Mediated Recognition [PDF]
, 2004 Sihyug Jang +3 more
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Contribution of perineuronal nets to hyperexcitability in pilocarpine‐induced status epilepticus
Epilepsia, EarlyView.Abstract Objective Changes in extracellular matrix (ECM) and highly condensed ECM structures called perineuronal nets (PNNs) have been reported in human patients with epilepsy as well as some animal models of epilepsy. We studied potential ECM changes in a mouse model of pilocarpine‐induced status epilepticus (PISE) and their potential contributions to
AnnaLin M. Woo +3 more
wiley +1 more source