Results 221 to 230 of about 101,572 (275)

TLR2 and IRF8 are the biomarkers associated with hypoxia in steroid-induced osteonecrosis of the femoral head via bioinformatics analysis and experimental validation. [PDF]

BMC Musculoskelet Disord
Zhang J, Wang J, Guo J, Wei B.
europepmc   +1 more source

PCSK9 and coronary atherosclerosis progression beyond LDL‐cholesterol in coronary artery disease patients

European Journal of Clinical Investigation, Volume 55, Issue 11, November 2025.
In a population of patients with stable CAD, circulating levels of PCSK9 are independently associated with the progression of adverse coronary plaque phenotypes, as assessed by serial coronary computed tomography angiography. At RNA‐seq analysis of whole blood, PCSK9 was linked to the expression of genes involved in the innate‐immune response.
Rosetta Ragusa, Silvia Rocchiccioli, Serena Del Turco, Antonio Morlando, Giuseppina Basta, Arthur Scholte, Danilo Neglia, Chiara Caselli   +7 more
wiley   +1 more source

Association of TNF and TLR2 genes with blood parameter levels in Mexican patients with schizophrenia. [PDF]

BMC Psychiatry
Cabello-Rangel H, Sotelo-Ramírez CE, Jiménez-Pavon J, Sanabrais-Jiménez MA, Morales-Cedillo P, Camarena B.   +5 more
europepmc   +1 more source

A Role for High Mobility Group Box 1 (HMGB1) Release in the Pathogenesis of Gastroesophageal Reflux Disease

Neurogastroenterology &Motility, Volume 37, Issue 11, November 2025.
Incubation of esophageal epithelial cells with a weakly acidic (pH 5) bile salt (deoxycholic acid) induces translocation of HMGB1 from the nucleus to the cytosol, and its subsequent release from the cell. This process can be ameliorated by pre‐treatment with the antioxidant, curcumin.
Tom Leech, David Kelsell, Diana Blaydon, Philip Woodland, Madusha Peiris   +4 more
wiley   +1 more source

SARS‐CoV‐2 Nucleocapsid Protein Does Not Induce Inflammation in Endothelial Cells or Monocytes

The FASEB Journal, Volume 39, Issue 20, 31 October 2025.
The SARS‐CoV‐2 nucleocapsid (N) protein was thought to trigger inflammation in endothelial cells and monocytes. We found that these effects were largely caused by trace endotoxin contamination in the recombinant N‐protein. When endotoxin was neutralized or removed, N‐protein no longer induced inflammation in endothelial cells or monocytes. Our findings
Mehreen Tufail, Xiangru Lu, Stephen D. Barr, Nica Borradaile, Qingping Feng   +4 more
wiley   +1 more source

A multi-epitope vaccine targeting a key virulence factor ClfA: An In-silico approach to combat Staphylococcus aureus infections. [PDF]

PLoS One
Nirob MNH, Sultana I, Al Arian T, Islam MS, Moniruzzzaman M, Nosi SJ, Halder SK, Shil A, Himel MK.   +8 more
europepmc   +1 more source

Bruton’s Tyrosine Kinase Is Required for TLR2 and TLR4-Induced TNF, but Not IL-6, Production

, 2006
Nicole J. Horwood, Theresa H. Page, John McDaid, Christine D. Palmer, Jamie I. D. Campbell, Tara Mahon, Fionula M. Brennan, David Webster, Brian M. J. Foxwell   +8 more
openalex   +1 more source

Prorenin in Hepatic Stellate Cell Extracellular Vesicles Induces Platelet‐Dependent Thrombin Formation and Release of Profibrotic TGF‐β

The FASEB Journal, Volume 39, Issue 20, 31 October 2025.
Platelets interact with extracellular vesicles shed by hepatic stellate cells to activate both cell types. Extracellular vesicles shed by activated hepatic stellate cells contain inactive prorenin. HSC‐EV interact with quiescent platelets to non‐proteolytically activate ligated prorenin.
Rui Chen, Emily Huang, Xianfang Wu, Megan R. McMullen, Xianjia Wang, Laura E. Nagy, Ge Jin, Scott J. Cameron, Thomas M. McIntyre   +8 more
wiley   +1 more source

Phage-mediated TLR2 signaling attenuates intracellular Mycobacterium abscessus survival in macrophages. [PDF]

Sci Rep
Kapoor H, Maves AM, Bowder MA, Danelishvili L.   +3 more
europepmc   +1 more source

Cell Line-Dependent Internalization, Persistence, and Immunomodulatory Effects of <i>Staphylococcus aureus</i> in Triple-Negative Breast Cancer. [PDF]

Cancers (Basel)
Rad SK, Li R, Yeo KKL, Cooksley C, Shaghayegh G, Vreugde S, Wu F, Tomita Y, Price TJ, Ingman WV, Townsend AR, Smith E.   +11 more
europepmc   +1 more source