Results 261 to 270 of about 101,572 (275)

The double life of TLR2

Science Signaling, 2021
TLR2 located in the endothelium promotes angiogenesis and inflammation.
Samantha Mahfoud, Tatiana V. Petrova
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TLR2 in murine atherosclerosis

Seminars in Immunopathology, 2007
Atherosclerosis was once thought to be solely a disease of lipid accumulation in the vessel wall. It does involve lipid accumulation, but inflammation appears to be an important driving factor. Consequently, our laboratory undertook to examine the role(s) of TLRs, and especially TLR2, in murine models of atherosclerosis.
Linda K. Curtiss, Peter S. Tobias
openaire   +3 more sources

Megakaryocyte TLR2: immunity bullet?

Blood, 2011
Innate immunity is the host defensive weapon against pathogens and this issue of Blood offers an interesting new bullet for the immune system gun by studying the role of Toll-like receptor 2 (TLR2) in megakaryocytic function; a field previously not explored.
PIGNATELLI, Pasquale, CARNEVALE, Roberto
openaire   +3 more sources

TLR2: for or against Candida albicans?

Trends in Microbiology, 2005
In a recent issue of Trends in Microbiology, Netea and coworkers presented their opinion that toll-like receptors (TLRs) are involved in escape from the defense mechanisms of the host [1]. In their article, the authors clearly identified three major TLR-mediated escape mechanisms that are used by microbial pathogens, such as Yersinia, Mycobacterium and
Daniel Gozalbo, M. Luisa Gil, Didier Fradelizi   +2 more
openaire   +3 more sources

Rare TLR2 mutations reduce TLR2 receptor function and can increase atopy risk

Allergy, 2009
Background:  Common genetic variations in toll‐like receptor 2 (TLR2), an innate pathogen recognition receptor, may influence the development of atopic diseases. So far, very little is known about the role of rare TLR2 mutations in these diseases.Objective:  We investigated the functional properties of six rare amino acid changes in TLR2 (and one amino
Thomas Illig, N. Klopp, Stephan Spiller, Michael Kormann, E. von Mutius, Michael Kabesch, Ruth Ferstl, Christian Vogelberg, Martin Depner, Carsten J. Kirschning   +9 more
openaire   +3 more sources

Lipid-associated membrane lipopeptides of M. arginini activate NF-κB by interacting with TLR2/1, TLR2/6, and TLR2/CD14

Molecular Genetics, Microbiology and Virology, 2009
Various strains of mycoplasmas cause the activation of transcriptional factor NF-κB as a result of interactions with different combinations of Toll-like receptors (TLRs). It is well known that MALP-2 protein of M. fermentans activates NF-κB through interactions with TLR2/6, activates lipid-associated membrane lipopeptides (LAMPs) of M.
Andrei V. Gudkov, Denis Y. Logunov, A L Gintsburg, B. S. Naroditskii, I. V. Rakovskaya, M M Shmarov, D. V. Scheblyakov, O. V. Zubkova   +7 more
openaire   +2 more sources

The Noninflammatory Side of TLR2

Science Signaling, 2012
Toll-like receptor 2 promotes tumorigenesis in a mouse model of gastric cancer, but not by enhancing inflammation.
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TLR2 agonists and their structure–activity relationships

Organic & Biomolecular Chemistry, 2020
We review the structure–activity relationships and synthetic studies of TLR2 agonists – important chemical targets in immunotherapy.
Benjamin L. Lu, Geoffrey M. Williams, Margaret A. Brimble   +2 more
openaire   +2 more sources

TLR2 joins the interferon gang

Nature Immunology, 2009
The induction of type I interferon is a critical checkpoint in antiviral immunity. Toll-like receptor 2 can unexpectedly induce type I interferon in the subset of inflammatory monocytes during infection with vaccinia virus.
Franz Bauernfeind, Veit Hornung
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