Results 1 to 10 of about 63,490 (224)

Computational design of a multiepitope vaccine targeting VP1 and VP2 capsid proteins of simian virus 40 (SV40) for enhanced immune activation [PDF]

Open Medicine
This study aimed to design and evaluate a computationally constructed multiepitope vaccine targeting Simian Virus 40 (SV40) by predicting and selecting immunogenic B-cell and T-cell epitopes derived from the VP1 and VP2 capsid proteins using ...
Naveed Muhammad, Asim Muhammad, Aziz Tariq, Amjad Sonia, Majeed Muhammad Nouman, Jamal Syed Babar, El Hadi Mohamed Rania Ali, Alwethaynani Maher S., Al-Joufi Fakhria A., Fallatah Deema, Alkhatib Shaza N.   +10 more
doaj   +2 more sources

MyD88 Contributes to TLR3-Mediated NF-κB Activation and Cytokine Production in Macrophages [PDF]

Cells
Toll-like receptor 3 (TLR3) initiates antiviral and inflammatory responses exclusively through the adaptor protein TRIF (TIR-domain-containing adapter-inducing interferon-β).
Zhuodong Chai, Yuqi Zhou, Ling Yang, Yan Zhang, Sukria Hossain, Sahelosadat Hajimirzaei, Jiaqian Qi, Guoying Zhang, Yinan Wei, Zhenyu Li   +9 more
doaj   +2 more sources

Toll-like receptor signaling in vertebrates: Testing the integration of protein, complex, and pathway data in the Protein Ontology framework [PDF]

, 2015
The Protein Ontology (PRO) provides terms for and supports annotation of species-specific protein complexes in an ontology framework that relates them both to their components and to species-independent families of complexes.
Arighi, Cecilia, D’Eustachio, Peter, Masci, Anna Maria, Natale, Darren, Ruttenberg, Alan, Shamovsky, Veronica, Smith, Barry, Wu, Cathy   +7 more
core   +10 more sources

Stimulating effect of double-stranded yeast RNA on the activity of interferon system genes

Медицинская иммунология, 2021
Influence of double-stranded RNA (dsRNA) from Saccharomyces cerevisiae yeast upon expression levels of the macrophage genes encoding TLR3 receptor, interferons alpha and beta (IFNα, IFNβ), 2’,5’-oligoadenylate synthetase (OAS) and protein kinase R (PKR ...
A. V. Bateneva, S. G. Gamaley, E. D. Danilenko, R. L. Lebedev   +3 more
doaj   +1 more source

The Role of MEG3 in the Activation of Toll Like Receptor 3 in Prostate Cancer Cells

Sakarya Tıp Dergisi, 2021
Objective: Prostate cancer accounts for approximately 10% of new cases diagnosed in men worldwide. Toll like receptors (TLRs) play a crucial role in the progression of cancer.
Gamze Güney Eskiler, Asuman Deveci Özkan, Erhan Bezdegümeli, Merve Nur İnce, Ahmet Yasir Men, Bilge Nur Küçükakça   +5 more
doaj   +1 more source

TLR3 serves as a novel diagnostic and prognostic biomarker and is closely correlated with immune microenvironment in three types of cancer

Frontiers in Genetics, 2022
Background: Toll-like receptor 3 (TLR3) plays an important role in both innate and adaptive immunity, but the prognostic value of TLR3 in heterogeneous tumors and the correlations between TLR3 expression and immune infiltration of heterogeneous tumors ...
Xiong Zou, Xiong Zou, Xiong Zou, Xiong Zou, Yi Guo, Yi Guo, Yi Guo, Yi Guo, Zengnan Mo, Zengnan Mo, Zengnan Mo, Zengnan Mo, Zengnan Mo   +12 more
doaj   +1 more source

Methylation Regulation of TLR3 on Immune Parameters in Lung Adenocarcinoma

Frontiers in Oncology, 2021
This study aims to analyze the methylation regulation of TLR3 in lung adenocarcinoma (LUAD) and to explore the association of TLR3 expression with immune microenvironment.
Ang Li, Ang Li, Hongjiao Wu, Qinqin Tian, Yi Zhang, Zhi Zhang, Xuemei Zhang, Xuemei Zhang   +7 more
doaj   +1 more source

HLA-A*0206 with TLR3 polymorphisms exerts more than additive effects in Stevens-Johnson syndrome with severe ocular surface complications. [PDF]

PLoS ONE, 2012
BACKGROUND: Stevens-Johnson syndrome (SJS) is an acute inflammatory vesiculobullous reaction of the skin and mucosa, often including the ocular surface, and toxic epidermal necrolysis (TEN) occurs with its progression.
Mayumi Ueta, Katsushi Tokunaga, Chie Sotozono, Hiromi Sawai, Gen Tamiya, Tsutomu Inatomi, Shigeru Kinoshita   +6 more
doaj   +1 more source

Microcefalia por Zika un problema latente: Reporte de Caso y Aspectos Moleculares

Infectio, 2020
We present the case of a 20-day-old patient from Cartagena (Bolívar), hospitalized for presenting a 6-day fever associated with respiratory symptoms with normal neurological evaluation. The obstetric ultrasound showed a microcephaly with a percentile of
Oscar Patiño
doaj   +1 more source

Roles of Toll-Like Receptor 3 in Human Tumors

Frontiers in Immunology, 2021
Toll-like receptor 3 (TLR3) is an important member of the TLR family, which is an important group of pathogen-associated molecular patterns. TLR3 can recognize double-stranded RNA and induce activation of NF-κB and the production of type I interferons ...
Xin Zheng, Song Li, Hui Yang
doaj   +1 more source