Results 1 to 10 of about 45,107 (147)

TLR3 Expression is a Potential Prognosis Biomarker and Shapes the Immune-Active Tumor Microenvironment in Esophageal Squamous Cell Carcinoma

Journal of Inflammation Research, 2022
Ruibing Su,1,* Lijun Cai,1,* Pan Xiong,1,* Zhiwei Liu,1,* Shaobin Chen,2 Xi Liu,1 Runhua Lin,1 Zhijin Lei,1 Dongping Tian,1 Min Su1 1Institute of Clinical Pathology, Department of Pathology, Shantou University Medical College, Shantou ...
Su R, Cai L, Xiong P, Liu Z, Chen S, Liu X, Lin R, Lei Z, Tian D, Su M   +9 more
doaj   +2 more sources

Extracellular RNAs-TLR3 signaling contributes to cognitive impairment after chronic neuropathic pain in mice

Signal Transduction and Targeted Therapy, 2023
Chronic pain is often associated with cognitive decline, which could influence the quality of the patient’s life. Recent studies have suggested that Toll-like receptor 3 (TLR3) is crucial for memory and learning.
Xueying Zhang, Rui Gao, Changteng Zhang, Yi Teng, Hai Chen, Qi Li, Changliang Liu, Jiahui Wu, Liuxing Wei, Liyun Deng, Lining Wu, Shixin Ye-Lehmann, Xiaobo Mao, Jin Liu, Tao Zhu, Chan Chen   +15 more
doaj   +2 more sources

MyD88 Contributes to TLR3-Mediated NF-κB Activation and Cytokine Production in Macrophages [PDF]

Cells
Toll-like receptor 3 (TLR3) initiates antiviral and inflammatory responses exclusively through the adaptor protein TRIF (TIR-domain-containing adapter-inducing interferon-β).
Zhuodong Chai, Yuqi Zhou, Ling Yang, Yan Zhang, Sukria Hossain, Sahelosadat Hajimirzaei, Jiaqian Qi, Guoying Zhang, Yinan Wei, Zhenyu Li   +9 more
doaj   +2 more sources

Stimulating effect of double-stranded yeast RNA on the activity of interferon system genes

Медицинская иммунология, 2021
Influence of double-stranded RNA (dsRNA) from Saccharomyces cerevisiae yeast upon expression levels of the macrophage genes encoding TLR3 receptor, interferons alpha and beta (IFNα, IFNβ), 2’,5’-oligoadenylate synthetase (OAS) and protein kinase R (PKR ...
A. V. Bateneva, S. G. Gamaley, E. D. Danilenko, R. L. Lebedev   +3 more
doaj   +1 more source

TLR3 forms a laterally aligned multimeric complex along double-stranded RNA for efficient signal transduction

Nature Communications, 2023
TLR3 activates a potent immune response by binding to dsRNA. Here the authors report cryo-EM analyses to show that TLR3 dimers laterally form a higher multimeric complex along dsRNA, providing the basis for cooperative binding and efficient signal ...
K. Sakaniwa, A. Fujimura, Takuma Shibata, H. Shigematsu, Toru Ekimoto, Masaki Yamamoto, M. Ikeguchi, K. Miyake, U. Ohto, Toshiyuki Shimizu   +9 more
semanticscholar   +1 more source

A novel defined TLR3 agonist as an effective vaccine adjuvant

Frontiers in Immunology, 2023
Synthetic double-stranded RNA analogs recognized by Toll-like receptor 3 (TLR3) are an attractive adjuvant candidate for vaccines, especially against intracellular pathogens or tumors, because of their ability to enhance T cell and antibody responses ...
Kwang Hyun Ko, S. Cha, Seung-Hwan Lee, H. Bae, Chulho Ham, Min-Gyu Lee, Dong-Ho Kim, Seung Hyun Han   +7 more
semanticscholar   +1 more source

TLR3 and TLR7 RNA Sensor Activation during SARS-CoV-2 Infection

Microorganisms, 2021
(1) Background: Acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent for the coronavirus disease (COVID-19) that has led to a pandemic that began in March 2020.
D. Bortolotti, V. Gentili, S. Rizzo, Giovanna Schiuma, S. Beltrami, Giovanni Strazzabosco, Mercedes Fernández, F. Caccuri, A. Caruso, R. Rizzo   +9 more
semanticscholar   +1 more source

The Role of MEG3 in the Activation of Toll Like Receptor 3 in Prostate Cancer Cells

Sakarya Tıp Dergisi, 2021
Objective: Prostate cancer accounts for approximately 10% of new cases diagnosed in men worldwide. Toll like receptors (TLRs) play a crucial role in the progression of cancer.
Gamze Güney Eskiler, Asuman Deveci Özkan, Erhan Bezdegümeli, Merve Nur İnce, Ahmet Yasir Men, Bilge Nur Küçükakça   +5 more
doaj   +1 more source

Toll-like receptor 3 (TLR3) regulation mechanisms and roles in antiviral innate immune responses

Journal of Zhejiang University SCIENCE B, 2021
Toll-like receptor 3 (TLR3) is a member of the TLR family, mediating the transcriptional induction of type I interferons (IFNs) proinflammatory cytokines, and chemokines, thereby collectively establishing an antiviral host response.
Yujuan Chen, Junhong Lin, Yao Zhao, Xian-Yong Ma, Huashan Yi   +4 more
semanticscholar   +1 more source

Photobiomodulation promotes spinal cord injury repair by inhibiting macrophage polarization through lncRNA TUG1-miR-1192/TLR3 axis

Cellular & Molecular Biology Letters, 2023
Background Secondary spinal cord injury (SCI) often causes the aggravation of inflammatory reaction and nerve injury, which affects the recovery of motor function.
Cheng Ju, Ya-Song Ma, Xiaoshuang Zuo, Xuankang Wang, Zhiwen Song, Zhihao Zhang, Zhijie Zhu, Xin Li, Zhuowen Liang, Tan Ding, Xueyu Hu, Zhe Wang   +11 more
semanticscholar   +1 more source