Results 11 to 20 of about 63,490 (224)

The TLR3 L412F polymorphism prevents TLR3-mediated tumor cell death induction in pediatric sarcomas

Cell Death Discovery, 2023
Toll-like receptor 3 (TLR3) is a pattern recognition receptor mainly known for its role in innate immune response to infection. Indeed, binding of double-stranded RNA (dsRNA) to TLR3 triggers a pro-inflammatory cascade leading to cytokine release and ...
Joseph Bisaccia, Swann Meyer, Adrien Bertrand-Chapel, Quentin Hecquet, Virginie Barbet, Bastien Kaniewski, Sophie Léon, Nicolas Gadot, Isabelle Rochet, Iveta Fajnorova, Pierre Leblond, Martine Cordier-Bussat, Nadège Corradini, Alexandre Vasiljevic, Marc Billaud, Cécile Picard, Laura Broutier, Cindy Gallerne, Aurélie Dutour, Jean-Yves Blay, Marie Castets   +20 more
doaj   +4 more sources

Differential toll-like receptor 3 (TLR3) expression and apoptotic response to TLR3 agonist in human neuroblastoma cells [PDF]

Journal of Biomedical Science, 2011
Background Toll-like receptor-3 (TLR-3) is a critical component of innate immune system against dsRNA viruses and is expressed in the central nervous system.
Du Yung-Ying, Wu Chia-Ling, Huang Chao-Cheng, Chuang Hui-Ching, Chuang Jiin-Haur, Kung Mei-Lang, Chen Chih-Hao, Chen San-Cher, Tai Ming-Hong   +8 more
doaj   +3 more sources

TLR3 Plays Significant Roles against HBV-Associated HCC [PDF]

Gastroenterology Research and Practice, 2015
Toll-like receptor 3 (TLR3) is a pattern-recognizing receptor that is involved in immune signaling and plays a crucial role in survival by being able to recognize various viral components including double-stranded RNA (dsRNA).
Xiao-lan Chen, Yu-yin Xu, Li Chen, Gui-lan Wang, Yin Shen   +4 more
doaj   +3 more sources

ZCCHC3 modulates TLR3-mediated signaling by promoting recruitment of TRIF to TLR3 [PDF]

Journal of Molecular Cell Biology, 2020
Abstract Toll-like receptor 3 (TLR3)-mediated signaling is important for host defense against RNA virus. Upon viral RNA stimulation, toll and interleukin-1 receptor domain-containing adaptor inducing IFN-β (TRIF) is recruited to TLR3 and then undergoes oligomerization, which is required for the recruitment of downstream molecules to ...
Zang, Ru, Lian, Huan, Zhong, Xuan, Yang, Qing, Shu, Hong-Bing   +4 more
openaire   +2 more sources

TLR3 impairment in human newborns [PDF]

Journal of Leukocyte Biology, 2013
ABSTRACTNewborns are highly susceptible to viral infections. We hypothesized that this susceptibility could be due to a dysregulated expression of innate virus-sensing receptors, i.e., TLR3, TLR7, TLR8, and TLR9 and the cytosolic receptors retinoic acid-inducible gene I, melanoma differentiation-associated protein 5, protein kinase R, and IFN-γ ...
Lucija, Slavica, Inger, Nordström, Merja Nurkkala, Karlsson, Hadi, Valadi, Marian, Kacerovsky, Bo, Jacobsson, Kristina, Eriksson   +6 more
openaire   +2 more sources

Both MicroRNA-155 and Virus-Encoded MiR-155 Ortholog Regulate TLR3 Expression. [PDF]

PLoS ONE, 2015
MicroRNA-155 (miR-155) has been as an important controller of TLR3 signalling. However, the interactions between miR-155 and TLR3 are poorly understood. Here, we focused on the regulation of the relationship between miR-155 and TLR3.
Xuming Hu, Jianqiang Ye, Aijian Qin, Haitao Zou, Hongxia Shao, Kun Qian   +5 more
doaj   +1 more source

Small molecule SMU-CX24 targeting toll-like receptor 3 counteracts inflammation: A novel approach to atherosclerosis therapy

Acta Pharmaceutica Sinica B, 2022
Toll-like receptor 3 (TLR3), as an important pattern recognition receptor (PRR), dominates the innate and adaptive immunity regulating many acute and chronic inflammatory diseases.
Xiaohong Cen, Baoqu Wang, Yuqing Liang, Yanlin Chen, Yu Xiao, Shaohua Du, Kutty Selva Nandakumar, Hang Yin, Shuwen Liu, Kui Cheng   +9 more
doaj   +1 more source

Regulation of TLR3 Activation by S100A9 [PDF]

The Journal of Immunology, 2015
Abstract Recognition of viral dsRNA by endosomal TLR3 activates innate immune response during virus infection. Trafficking of TLR3 to the endolysosomal compartment arising from fusion of late endosome (LE) with lysosome is required for recognition and detection of pathogen associated molecular patterns, which results in activation of the
Su-Yu, Tsai, Jesus A, Segovia, Te-Hung, Chang, Niraj K, Shil, Swechha M, Pokharel, T R, Kannan, Joel B, Baseman, Joan, Defrêne, Nathalie, Pagé, Annabelle, Cesaro, Philippe A, Tessier, Santanu, Bose   +11 more
openaire   +2 more sources

Immunomodulatory Effect of Toll-Like Receptor-3 Ligand Poly I:C on Cortical Spreading Depression [PDF]

, 2009
The release of inflammatory mediators following cortical spreading depression (CSD) is suggested to play a role in pathophysiology of CSD-related neurological disorders.
Aghabarari, A., Ghaemi, A., Gorji, A., Khaleghi Ghadiri, M., Khodaie, B., Lotfinia, A.A., Lotfinia, M., Meuth, S., Sajadian, A.   +8 more
core   +3 more sources

The zinc-finger protein ZFYVE1 modulates TLR3-mediated signaling by facilitating TLR3 ligand binding [PDF]

Cellular & Molecular Immunology, 2019
Recognition of viral dsRNA by Toll-like receptor 3 (TLR3) leads to the induction of downstream antiviral effectors and the innate antiviral immune response. Here, we identified the zinc-finger FYVE domain-containing protein ZFYVE1, a guanylate-binding protein (GBP), as a positive regulator of TLR3-mediated signaling.
Xuan Zhong, Lu Feng, Wen-Hua Xu, Xin Wu, Yi-Di Ding, Yan Zhou, Cao-Qi Lei, Hong-Bing Shu   +7 more
openaire   +2 more sources