Results 11 to 20 of about 45,202 (234)
Trial watch: TLR3 agonists in cancer therapy [PDF]
OncoImmunology, 2020 Toll-like receptor 3 (TLR3) is a pattern recognition receptor that senses exogenous (viral) as well as endogenous (mammalian) double-stranded RNA in endosomes. On activation, TLR3 initiates a signal transduction pathway that culminates with the secretion
Julie Le Naour +4 more
semanticscholar +4 more sources
ZCCHC3 modulates TLR3-mediated signaling by promoting recruitment of TRIF to TLR3 [PDF]
Journal of Molecular Cell Biology, 2020 Toll-like receptor 3 (TLR3)-mediated signaling is important for host defense against RNA virus. Upon viral RNA stimulation, toll and interleukin-1 receptor domain-containing adaptor inducing IFN-β (TRIF) is recruited to TLR3 and then undergoes ...
Ru Zang +4 more
semanticscholar +3 more sources
The TLR3 L412F polymorphism prevents TLR3-mediated tumor cell death induction in pediatric sarcomas
Cell Death Discovery, 2023 Toll-like receptor 3 (TLR3) is a pattern recognition receptor mainly known for its role in innate immune response to infection. Indeed, binding of double-stranded RNA (dsRNA) to TLR3 triggers a pro-inflammatory cascade leading to cytokine release and ...
Joseph Bisaccia +20 more
doaj +4 more sources
Differential toll-like receptor 3 (TLR3) expression and apoptotic response to TLR3 agonist in human neuroblastoma cells [PDF]
Journal of Biomedical Science, 2011 Background Toll-like receptor-3 (TLR-3) is a critical component of innate immune system against dsRNA viruses and is expressed in the central nervous system.
Du Yung-Ying +8 more
doaj +3 more sources
TLR3 Plays Significant Roles against HBV-Associated HCC [PDF]
Gastroenterology Research and Practice, 2015 Toll-like receptor 3 (TLR3) is a pattern-recognizing receptor that is involved in immune signaling and plays a crucial role in survival by being able to recognize various viral components including double-stranded RNA (dsRNA).
Xiao-lan Chen +4 more
doaj +3 more sources
TLR3 forms a highly organized cluster when bound to a poly(I:C) RNA ligand
Nature Communications, 2022 Toll-like Receptor 3 (TLR3) initiates a potent anti-viral immune response by binding to double-stranded RNA ligands. Previous crystallographic studies showed that TLR3 forms a homodimer when bound to a 46-base pair RNA ligand.
Chan Seok Lim +6 more
semanticscholar +1 more source
TLR3 agonists: RGC100, ARNAX, and poly-IC: a comparative review
Immunologic research, 2021 Toll-like receptors 3 (TLR3) have been broadly studied among all TLRs over the last few decades together with its agonists due to their contribution to cancer regression.
Asma Komal, Mamoona Noreen, A. El‐kott
semanticscholar +1 more source
Cell Death and Disease, 2021 A leading cause of preterm birth is the exposure to systemic inflammation (maternal/fetal infection), which leads to neuroinflammation and white matter injury (WMI).
M. Boccazzi +10 more
semanticscholar +1 more source
TLR3 impairment in human newborns [PDF]
Journal of Leukocyte Biology, 2013 ABSTRACTNewborns are highly susceptible to viral infections. We hypothesized that this susceptibility could be due to a dysregulated expression of innate virus-sensing receptors, i.e., TLR3, TLR7, TLR8, and TLR9 and the cytosolic receptors retinoic acid-inducible gene I, melanoma differentiation-associated protein 5, protein kinase R, and IFN-γ ...
Lucija, Slavica +6 more
openaire +2 more sources
Frontiers in Genetics, 2022 Background: Toll-like receptor 3 (TLR3) plays an important role in both innate and adaptive immunity, but the prognostic value of TLR3 in heterogeneous tumors and the correlations between TLR3 expression and immune infiltration of heterogeneous tumors ...
Xiong Zou +12 more
doaj +1 more source