Activation of interferon regulatory factor-3 via toll-like receptor 3 and immunomodulatory functions detected in A549 lung epithelial cells exposed to misplaced U1-snRNA [PDF]
, 2009 U1-snRNA is an integral part of the U1 ribonucleoprotein pivotal for pre-mRNA splicing. Toll-like receptor (TLR) signaling has recently been associated with immunoregulatory capacities of U1-snRNA.
C. D. Sadik +59 more
core +1 more source
Trial watch: TLR3 agonists in cancer therapy [PDF]
OncoImmunology, 2020 Toll-like receptor 3 (TLR3) is a pattern recognition receptor that senses exogenous (viral) as well as endogenous (mammalian) double-stranded RNA in endosomes. On activation, TLR3 initiates a signal transduction pathway that culminates with the secretion of pro-inflammatory cytokines including type I interferon (IFN).
Naour, Julie Le +4 more
openaire +3 more sources
Chicken Toll-like Receptor 3 Recognizes Its Cognate Ligand When Ectopically Expressed in Human Cells [PDF]
, 2007 Recognition of pathogens by toll-like receptors (TLRs) causes activation of signaling cascades that trigger cytokine secretion and, ultimately, innate immunity.
Bauer, Stefan +7 more
core +1 more source
Caspase-8 controls the gut response to microbial challenges by Tnf-alpha-dependent and independent pathways [PDF]
, 2014 Objectives: Intestinal epithelial cells (IEC) express toll-like receptors (TLR) that facilitate microbial recognition. Stimulation of TLR ligands induces a transient increase in epithelial cell shedding, a mechanism that serves the antibacterial and ...
Basic, Marijana +12 more
core +3 more sources
Yonsei Medical Journal, 2004 Toll-like receptor (TLR) 3 is a member of the TLR family that confers innate immunity by recognizing viral pathogens. Herein, we report that the TLR3 isoform is expressed on human primary cells and cell lines. This isoform has 2,520 bp cDNAs compared to the 2,712 bp of full cDNA, is produced by deletion of an intron-like sequence within exon 4 and is ...
Eunjeong, Yang +6 more
openaire +2 more sources
BMC Cancer, 2023 Introduction We have previously reported that Toll-like receptor 3 (TLR3) acts as a suppressor gene for breast cancer initiation and progression. In this study, we evaluated the role of TLR3 in breast cancer using our original Fudan University Shanghai ...
Lei Fan +5 more
doaj +1 more source
LL37 and cationic peptides enhance TLR3 signaling by viral double-stranded RNAs. [PDF]
PLoS ONE, 2011 BACKGROUND:Toll-like Receptor 3 (TLR3) detects viral dsRNA during viral infection. However, most natural viral dsRNAs are poor activators of TLR3 in cell-based systems, leading us to hypothesize that TLR3 needs additional factors to be activated by viral
Yvonne Lai +9 more
doaj +1 more source
TLR3 Deficiency Leads to a Dysregulation in the Global Gene-Expression Profile in Murine Oviduct Epithelial Cells Infected with Chlamydia muridarum [PDF]
, 2019 OBJECTIVE Describe the implementation and effects of Mobile Acute Care for Elders (MACE) consultation at a Veterans Affairs Medical Center (VAMC). DESIGN Retrospective cohort analysis.
Derbigny, Wilbert A, Kumar, Ramesh
core +2 more sources
TLR3 agonists and proinflammatory antitumor activities [PDF]
Expert Opinion on Therapeutic Targets, 2013 Although tumor growth leads to inflammatory responses, the immune system develops tolerance to cancer. One way to break host tolerance to tumors is to activate key immune effector activities. Toward this end, various adjuvants are under investigation in an effort to harness the immune system to overcome tolerance to tumor-associated self-antigens ...
Sherven, Sharma +7 more
openaire +2 more sources
Participation of Endosomes in Toll-Like Receptor 3 Transportation Pathway in Murine Astrocytes
Frontiers in Cellular Neuroscience, 2020 TLR3 provides immediate type I IFN response following entry of stimulatory PAMPs into the CNS, as it is in HSV infection. The receptor plays a vital role in astrocytes, contributing to rapid infection sensing and suppression of viral replication ...
Matylda B. Mielcarska +11 more
doaj +1 more source