Results 31 to 40 of about 45,202 (234)
Journal of Experimental Medicine, 2021 The authors report inborn error of TLR3 or MDA5 in two unrelated children with enterovirus rhombencephalitis. TLR3 and MDA5 may control anti-enterovirus immunity in central nervous system cells via the maintenance of basal or virus-induced type I IFN ...
Jie Chen +19 more
semanticscholar +1 more source
BMC Cancer, 2023 Introduction We have previously reported that Toll-like receptor 3 (TLR3) acts as a suppressor gene for breast cancer initiation and progression. In this study, we evaluated the role of TLR3 in breast cancer using our original Fudan University Shanghai ...
Lei Fan +5 more
doaj +1 more source
Journal of Immunology, 2021 Key Points Activation of TLR3+ moDCs predominates after respiratory viral infection. TLR3 and moDCs are required for progressive postviral lung disease. TLR3+ moDCs expand lung epithelial cells that are key to postviral disease.
Xinyu Wang +6 more
semanticscholar +1 more source
Yonsei Medical Journal, 2004 Toll-like receptor (TLR) 3 is a member of the TLR family that confers innate immunity by recognizing viral pathogens. Herein, we report that the TLR3 isoform is expressed on human primary cells and cell lines. This isoform has 2,520 bp cDNAs compared to the 2,712 bp of full cDNA, is produced by deletion of an intron-like sequence within exon 4 and is ...
Eunjeong, Yang +6 more
openaire +2 more sources
LL37 and cationic peptides enhance TLR3 signaling by viral double-stranded RNAs. [PDF]
PLoS ONE, 2011 BACKGROUND:Toll-like Receptor 3 (TLR3) detects viral dsRNA during viral infection. However, most natural viral dsRNAs are poor activators of TLR3 in cell-based systems, leading us to hypothesize that TLR3 needs additional factors to be activated by viral
Yvonne Lai +9 more
doaj +1 more source
Participation of Endosomes in Toll-Like Receptor 3 Transportation Pathway in Murine Astrocytes
Frontiers in Cellular Neuroscience, 2020 TLR3 provides immediate type I IFN response following entry of stimulatory PAMPs into the CNS, as it is in HSV infection. The receptor plays a vital role in astrocytes, contributing to rapid infection sensing and suppression of viral replication ...
Matylda B. Mielcarska +11 more
doaj +1 more source
Skewed endosomal RNA responses from TLR7 to TLR3 in RNase T2-deficient macrophages.
International Immunology, 2021 RNase T2, a ubiquitously expressed RNase, degrades RNAs in the endosomal compartments. RNA sensors, double-stranded RNA (dsRNA)-sensing TLR3 and single-stranded RNA (ssRNA)-sensing TLR7, are localized in the endosomal compartment in mouse macrophages. We
Kaiwen Liu +11 more
semanticscholar +1 more source
TLR3 agonists and proinflammatory antitumor activities [PDF]
Expert Opinion on Therapeutic Targets, 2013 Although tumor growth leads to inflammatory responses, the immune system develops tolerance to cancer. One way to break host tolerance to tumors is to activate key immune effector activities. Toward this end, various adjuvants are under investigation in an effort to harness the immune system to overcome tolerance to tumor-associated self-antigens ...
Sherven, Sharma +7 more
openaire +2 more sources
Frontiers in Immunology, 2021 Toll-like receptor (TLR) signaling is critical for defense against pathogenic infection, as well as for modulating tissue development. Activation of different TLRs triggers common inflammatory responses such as cytokine induction.
Chiung-Ya Chen +7 more
doaj +1 more source
A TRIF-Independent Branch of TLR3 Signaling [PDF]
The Journal of Immunology, 2012 Abstract dsRNA is a common pathogen-associated molecular pattern that is recognized by cellular TLR3 and used by virus-infected cells to activate specific transcription factors and trigger induction of antiviral genes. In this article, we report a new branch of TLR3 signaling that does not lead to gene induction but affects many ...
Michifumi, Yamashita +4 more
openaire +2 more sources