Results 31 to 40 of about 63,490 (224)
Frontiers in Immunology, 2021 Toll-like receptor (TLR) signaling is critical for defense against pathogenic infection, as well as for modulating tissue development. Activation of different TLRs triggers common inflammatory responses such as cytokine induction.
Chiung-Ya Chen +7 more
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Respiratory antiviral immunity and immunobiotics: Beneficial effects on inflammation-coagulation interaction during influenza virus infection [PDF]
, 2016 Influenza virus (IFV) is a major respiratory pathogen of global importance, and the cause of a high degree of morbidity and mortality, especially in high-risk populations such as infants, elderly, and immunocompromised hosts.
Alvarez, Gladis Susana +3 more
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A TRIF-Independent Branch of TLR3 Signaling [PDF]
The Journal of Immunology, 2012 Abstract dsRNA is a common pathogen-associated molecular pattern that is recognized by cellular TLR3 and used by virus-infected cells to activate specific transcription factors and trigger induction of antiviral genes. In this article, we report a new branch of TLR3 signaling that does not lead to gene induction but affects many ...
Michifumi, Yamashita +4 more
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Inflammatory Regulation by TLR3 in Acute Hepatitis [PDF]
The Journal of Immunology, 2009 Abstract TLR3 is known to respond to dsRNA from viruses, apoptotic cells, and/or necrotic cells. Dying cells are a rich source of ligands that can activate TLRs, such as TLR3. TLR3 expressed in the liver is likely to be a mediator of innate activation and inflammation in the liver.
Xiao, Xiaoyan +8 more
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Toll-like receptor 3 signaling on macrophages is required for survival following coxsackievirus B4 infection. [PDF]
PLoS ONE, 2009 Toll-like receptor 3 (TLR3) has been proposed to play a central role in the early recognition of viruses by sensing double stranded RNA, a common intermediate of viral replication.
Martin J Richer +3 more
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Cross-disease innate gene signature: Emerging diversity and abundance in RA comparing to SLE and SSc [PDF]
, 2019 Overactivation of the innate immune system together with the impaired downstream pathway of type I interferon-responding genes is a hallmark of rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and systemic sclerosis (SSc).
Fillerová, Regina +8 more
core +1 more source
TLR3 Sensing of Viral Infection [PDF]
The Open Infectious Diseases Journal, 2010 Viral infection is detected by the innate immune system which mounts a rapid semi-selective defence involving inflammation and production of type 1 interferons. Several sensors, both cell surface and intracellular, exist to detect different types of viral motifs.
F. Dunlevy +2 more
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Heterozygous TLR3 Mutation in Patients with Hantavirus Encephalitis [PDF]
Journal of Clinical Immunology, 2020 AbstractPuumala hantavirus (PUUV) hemorrhagic fever with renal syndrome (HFRS) is common in Northern Europe; this infection is usually self-limited and severe complications are uncommon. PUUV and other hantaviruses, however, can rarely cause encephalitis. The pathogenesis of these rare and severe events is unknown.
Terhi Partanen +20 more
openaire +6 more sources
Class A scavenger receptor 1 (MSR1) restricts hepatitis C virus replication by mediating toll-like receptor 3 recognition of viral RNAs produced in neighboring cells [PDF]
, 2013 Persistent infections with hepatitis C virus (HCV) may result in life-threatening liver disease, including cirrhosis and cancer, and impose an important burden on human health.
Dansako, Hiromichi +6 more
core +4 more sources
Journal of Inflammation Research, 2022 Ruibing Su,1,* Lijun Cai,1,* Pan Xiong,1,* Zhiwei Liu,1,* Shaobin Chen,2 Xi Liu,1 Runhua Lin,1 Zhijin Lei,1 Dongping Tian,1 Min Su1 1Institute of Clinical Pathology, Department of Pathology, Shantou University Medical College, Shantou ...
Su R +9 more
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