Results 41 to 50 of about 45,202 (234)

Inflammatory Regulation by TLR3 in Acute Hepatitis [PDF]

The Journal of Immunology, 2009
Abstract TLR3 is known to respond to dsRNA from viruses, apoptotic cells, and/or necrotic cells. Dying cells are a rich source of ligands that can activate TLRs, such as TLR3. TLR3 expressed in the liver is likely to be a mediator of innate activation and inflammation in the liver.
Xiao, Xiaoyan, Zhao, Peng, Rodriguez-Pinto, Daniel, Qi, Dake, Henegariu, Octavian, Alexopoulou, Lena, Flavell, Richard A, Wong, F Susan, Wen, Li   +8 more
openaire   +8 more sources

Toll-like receptor 3 signaling on macrophages is required for survival following coxsackievirus B4 infection. [PDF]

PLoS ONE, 2009
Toll-like receptor 3 (TLR3) has been proposed to play a central role in the early recognition of viruses by sensing double stranded RNA, a common intermediate of viral replication.
Martin J Richer, Danielle J Lavallée, Iryna Shanina, Marc S Horwitz   +3 more
doaj   +1 more source

TLR3 controls constitutive IFN-β antiviral immunity in human fibroblasts and cortical neurons.

Journal of Clinical Investigation, 2020
Human herpes simplex virus 1 (HSV-1) encephalitis can be caused by inborn errors of the TLR3 pathway, resulting in impairment of CNS cell-intrinsic antiviral immunity.
Daxing Gao, Michael J. Ciancanelli, Peng Zhang, O. Harschnitz, V. Bondet, Mary L. Hasek, Jie Chen, X. Mu, Y. Itan, A. Cobat, V. Sancho-Shimizu, Benedetta Bigio, Lazaro Lorenzo, G. Ciceri, Jessica L McAlpine, E. Anguiano, E. Jouanguy, D. Chaussabel, I. Meyts, M. Diamond, L. Abel, S. Hur, Gregory A. Smith, L. Notarangelo, D. Duffy, L. Studer, J. Casanova, Shen-Ying Zhang   +27 more
semanticscholar   +1 more source

TLR3 Sensing of Viral Infection [PDF]

The Open Infectious Diseases Journal, 2010
Viral infection is detected by the innate immune system which mounts a rapid semi-selective defence involving inflammation and production of type 1 interferons. Several sensors, both cell surface and intracellular, exist to detect different types of viral motifs.
F. Dunlevy, N. G. McElvaney, C. M. Greene   +2 more
openaire   +1 more source

Association of TLR3 functional variant (rs3775291) with COVID-19 susceptibility and death: a population-scale study

Human Cell, 2021
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing the recent pandemic of coronavirus disease-19 (COVID-19) has a long, positive-sense, non-segmented single-stranded RNA (ssRNA) entrapped by an envelope with spikes.
G. Dhangadamajhi, Ronnaly Rout
semanticscholar   +1 more source

Toll-like receptor 3 regulates neural stem cell proliferation by modulating the Sonic Hedgehog pathway. [PDF]

PLoS ONE, 2011
Toll-like receptor 3 (TLR3) signaling has been implicated in neural stem/precursor cell (NPC) proliferation. However, the molecular mechanisms involved, and their relationship to classical TLR-mediated innate immune pathways, remain unknown.
Kavitha Yaddanapudi, Joari De Miranda, Mady Hornig, W Ian Lipkin   +3 more
doaj   +1 more source

SNO-MLP (S-Nitrosylation of Muscle LIM Protein) Facilitates Myocardial Hypertrophy Through TLR3 (Toll-Like Receptor 3)–Mediated RIP3 (Receptor-Interacting Protein Kinase 3) and NLRP3 (NOD-Like Receptor Pyrin Domain Containing 3) Inflammasome Activation

Circulation, 2020
Supplemental Digital Content is available in the text. Background: S-nitrosylation (SNO), a prototypic redox-based posttranslational modification, is involved in the pathogenesis of cardiovascular disease.
Xin Tang, Lihong Pan, Shuang Zhao, Feiyue Dai, Meng Chao, Hong Jiang, Xuesong Li, Zhe Lin, Zheng-rong Huang, Guoliang Meng, Chun Wang, Chan Chen, Jin Liu, Xin Wang, A. Ferro, Hong Wang, Hongshan Chen, Yuanqing Gao, Qiulun Lu, Liping Xie, Yi Han, Yong Ji   +21 more
semanticscholar   +1 more source

Heterozygous TLR3 Mutation in Patients with Hantavirus Encephalitis [PDF]

Journal of Clinical Immunology, 2020
AbstractPuumala hantavirus (PUUV) hemorrhagic fever with renal syndrome (HFRS) is common in Northern Europe; this infection is usually self-limited and severe complications are uncommon. PUUV and other hantaviruses, however, can rarely cause encephalitis. The pathogenesis of these rare and severe events is unknown.
Terhi Partanen, Jie Chen, Johanna Lehtonen, Outi Kuismin, Harri Rusanen, Olli Vapalahti, Antti Vaheri, Veli-Jukka Anttila, Michaela Bode, Nina Hautala, Tytti Vuorinen, Virpi Glumoff, Minna Kraatari, Pirjo Åström, Janna Saarela, Heikki Kauma, Lazaro Lorenzo, Jean-Laurent Casanova, Shen-Ying Zhang, Mikko Seppänen, Timo Hautala   +20 more
openaire   +6 more sources

Bufalin Suppresses Migration and Invasion of Hepatocellular Carcinoma Cells Elicited by Poly (I:C) Therapy

OncoImmunology, 2018
The Toll-like receptor 3 (TLR3) agonists as polyriboinosinic–polyribocytidylic acid (poly (I:C)) have been implicated as potential immunotherapy adjuvant for cancer whereas the exact roles of TLR3 agonists in hepatocellular carcinoma (HCC) treatment have
Yinglu Feng, Yongan Chen, Yongbin Meng, Qingxin Cao, Qun Liu, Changquan Ling, Chen Wang   +6 more
doaj   +1 more source

Myeloid Differentiation Primary Response 88–Cyclin D1 Signaling in Breast Cancer Cells Regulates Toll-Like Receptor 3-Mediated Cell Proliferation

Frontiers in Oncology, 2020
Toll-like receptor 3 (TLR3)-mediated apoptotic changes in cancer cells are well-documented, and hence, several synthetic ligands of TLR3 are being used for adjuvant therapy, but there are reports showing a contradictory effect of TLR3 signaling, which ...
Aradhana Singh, Ranjitsinh Devkar, Anupam Basu   +2 more
doaj   +1 more source