Results 51 to 60 of about 45,202 (234)

Viral double-strand RNA-binding proteins can enhance innate immune signaling by toll-like Receptor 3. [PDF]

PLoS ONE, 2011
Toll-like Receptor 3 (TLR3) detects double-stranded (ds) RNAs to activate innate immune responses. While poly(I:C) is an excellent agonist for TLR3 in several cell lines and in human peripheral blood mononuclear cells, viral dsRNAs tend to be poor ...
Yvonne Lai, Guanghui Yi, Alice Chen, Kanchan Bhardwaj, Brady J Tragesser, Rodrigo A Valverde, Adam Zlotnick, Suchetana Mukhopadhyay, C T Ranjith-Kumar, C Cheng Kao   +9 more
doaj   +1 more source

Toll-like receptor 3 modulates the behavioral effects of cocaine in mice

Journal of Neuroinflammation, 2018
Background The nucleus accumbens in the midbrain dopamine limbic system plays a key role in cocaine addiction. Toll-like receptors (TLRs) are important pattern-recognition receptors (PPRs) in the innate immune system that are also involved in drug ...
Ruiming Zhu, Qian Bu, Dengqi Fu, Xue Shao, Linhong Jiang, Wei Guo, Bo Chen, Bin Liu, Zhengtao Hu, Jingwei Tian, Yinglan Zhao, Xiaobo Cen   +11 more
doaj   +1 more source

TLR3 Expression Induces Apoptosis in Human Non-Small-Cell Lung Cancer

International Journal of Molecular Sciences, 2020
The prognostic value of Toll-like receptor 3 (TLR3) is debated in cancer, differing between tumor types, methods, and cell types. We recently showed for the first time that TLR3 expression on early stage non-small-cell lung cancer (NSCLC) results ...
F. Bianchi, S. Alexiadis, C. Camisaschi, M. Truini, G. Centonze, M. Milione, A. Balsari, E. Tagliabue, L. Sfondrini   +8 more
semanticscholar   +1 more source

Dissecting TLR3 signalling in dendritic cells

Immunobiology, 2010
Toll-like receptor (TLR) 3 recognizes double-stranded RNA and triggers the production of type 1 interferon and inflammatory cytokines/chemokines. Its engagement in dendritic cells (DCs) induces their maturation into potent immunostimulatory cells endowed with the capacity to efficiently cross-prime T lymphocytes.
M Cristina, Gauzzi, Manuela, Del Cornò, Sandra, Gessani   +2 more
openaire   +2 more sources

Coagulation Disorders in COVID-19: Role of Toll-like Receptors

Journal of Inflammation Research, 2020
Indranil Biswas,1 Gausal A Khan2 1Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA; 2Department of Physiology & Physiotherapy, College of Medicine, Nursing and Health Sciences, Fiji National ...
Biswas I, Khan GA
doaj  

Toll like receptor 3 plays a critical role in the progression and severity of acetaminophen-induced hepatotoxicity. [PDF]

PLoS ONE, 2013
Toll-like receptor (TLR) activation has been implicated in acetaminophen (APAP)-induced hepatotoxicity. Herein, we hypothesize that TLR3 activation significantly contributed to APAP-induced liver injury.
Karen A Cavassani, Ana Paula Moreira, David Habiel, Toshihiro Ito, Ana Lucia Coelho, Ron M Allen, Bin Hu, Janna Raphelson, William F Carson, Matthew A Schaller, Nicholas W Lukacs, M Bishr Omary, Cory M Hogaboam, Steven L Kunkel   +13 more
doaj   +1 more source

Key roles for phosphorylation and the Coiled-coil domain in TRIM56-mediated positive regulation of TLR3-TRIF–dependent innate immunity

Journal of Biological Chemistry
Tripartite-motif protein-56 (TRIM56) positively regulates the induction of type I interferon response via the TLR3 pathway by enhancing IRF3 activation and depends on its C-terminal residues 621-750 for interacting with the adaptor TRIF.
Benjamin M. Liu, Nan L. Li, Ruixue Wang, Xiaofan Li, Z. A. Li, Tony N. Marion, Kui Li   +6 more
semanticscholar   +1 more source

Severe influenza pneumonitis in children with inherited TLR3 deficiency

Journal of Experimental Medicine, 2019
The authors report three unrelated children with inherited TLR3 deficiency, impaired TLR3-dependent, IFN-α/β– and/or -λ–mediated, pulmonary epithelial cell–intrinsic immunity to influenza A virus, and life-threatening influenza pneumonitis.
H. Lim, S. X. Huang, Jie Chen, G. Kerner, O. Gilliaux, Paul Bastard, K. Dobbs, Nicholas Hernandez, Nicolas Goudin, Mary L. Hasek, Eduardo J. Garcia Reino, Fabien G. Lafaille, Lazaro Lorenzo, P. Luthra, Tatiana Kochetkov, Benedetta Bigio, S. Boucherit, F. Rozenberg, C. Védrinne, M. Keller, Y. Itan, A. García-Sastre, M. Célard, J. Orange, Michael J. Ciancanelli, I. Meyts, Qian Zhang, L. Abel, L. Notarangelo, H. Snoeck, J. Casanova, Shen-Ying Zhang   +31 more
semanticscholar   +1 more source

LL-37 and Double-Stranded RNA Synergistically Upregulate Bronchial Epithelial TLR3 Involving Enhanced Import of Double-Stranded RNA and Downstream TLR3 Signaling

Biomedicines, 2022
The human host defense peptide LL-37 influences double-stranded RNA signaling, but this process is not well understood. Here, we investigate synergistic actions of LL-37 and synthetic double-stranded RNA (poly I:C) on toll-like receptor 3 (TLR3 ...
Sara Bodahl, Samuel Cerps, Lena Uller, Bengt-Olof Nilsson   +3 more
doaj   +1 more source

Poly(I:C) preconditioning protects the heart against myocardial ischemia/reperfusion injury through TLR3/PI3K/Akt-dependent pathway

Signal Transduction and Targeted Therapy, 2020
Emerging evidence suggests that Toll-like receptors (TLRs) ligands pretreatment may play a vital role in the progress of myocardial ischemia/reperfusion (I/R) injury.
Erya Chen, Chan Chen, Zhendong Niu, L. Gan, Qiao Wang, Ming Li, Xingwei Cai, Rui Gao, Sruthi Katakam, Hai Chen, Shu Zhang, Ronghua Zhou, Xu Cheng, Yanhua Qiu, Hai Yu, Tao Zhu, Jin Liu   +16 more
semanticscholar   +1 more source