Results 1 to 10 of about 175,490 (344)
TLR4: the fall guy in sepsis? [PDF]
Cell Stress, 2020 Sepsis and its impact on human health can be traced back to 1000 BC and continues to be a major health burden today. It causes about 11 million deaths world-wide of which, more than a third are due to neonatal sepsis.
Joseph Menassa +3 more
doaj +4 more sources
Polymorphisms of TLR4: Rapid Genotyping and Reduced Response to Lipopolysaccharide of TLR4 Mutant Alleles [PDF]
Clinical Chemistry, 2002 AbstractBackground: Pathogen recognition receptors such as Toll-like receptors (TLRs), which recognize pathogen-associated molecular patterns, lead to the activation of innate immunity. Genetic variations in these receptors may lead to an altered host immune response to pathogens.Methods: We developed homogeneous fluorescence-based PCR assays as well ...
Christopher A. Schmitt +4 more
openalex +4 more sources
Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus [PDF]
Nature Immunology, 2000 Evelyn A. Kurt‐Jones +10 more
openalex +2 more sources
Polymorphism study of TLR4 gene in crossbred cattle of Kerala [PDF]
Journal of Veterinary and Animal Sciences, 2023 The present study was conducted to identify single nucleotide variations in exon 3 region of the bovine Toll-Like Receptor gene (TLR4) associated with somatic cell score (SCS) in crossbred cattle of Kerala using polymerase chain reaction-single ...
G. Chishi Kiyevi +5 more
doaj +1 more source
Effects of Escherichia coli lipopolysaccharide on innate immunity: The expression profile of TLR4 and CD14 genes in rat's liver [PDF]
Open Veterinary Journal, 2021 Background: Bacterial Endotoxin (lipopolysaccharide) is essential for bacterial virulence, as it has a biphasic effect which is either harmful and leads to aseptic shock and death or assists the body defense mechanisms as it stimulates B-cells activation.
Ammar M. Al-Aalim +2 more
doaj +1 more source
Inflammatory signaling of HMGB1 in depressive disorder
Stress and Brain, 2023 Background:Depressive disorder is a common disease characterized by depressed mood and loss of pleasure, which often brings a great grief to patients and a huge burden to the society.
Qian Jiang +4 more
doaj +1 more source
Toll-like receptor 4 (TLR4): new insight immune and aging
Immunity & Ageing, 2023 TLR4, a transmembrane receptor, plays a central role in the innate immune response. TLR4 not only engages with exogenous ligands at the cellular membrane’s surface but also interacts with intracellular ligands, initiating intricate intracellular ...
Hyo-Jin Kim +3 more
semanticscholar +1 more source
Mediators of Inflammation, 2021 Causes of mortality from COVID-19 include respiratory failure, heart failure, and sepsis/multiorgan failure. TLR4 is an innate immune receptor on the cell surface that recognizes pathogen-associated molecular patterns (PAMPs) including viral proteins and
Mohamed M. Aboudounya, R. Heads
semanticscholar +1 more source
TLR4 and Insulin Resistance [PDF]
Gastroenterology Research and Practice, 2010 Chronic inflammation is a key feature of insulin resistance and obesity. Toll-Like Receptor 4 (TLR4), involved in modulating innate immunity, is an important mediator of insulin resistance and its comorbidities. TLR4 contributes to the development of insulin resistance and inflammation through its activation by elevated exogenous ligands (e.g., dietary
Jane J. Kim, Dorothy D. Sears
openaire +4 more sources
Microbiome, 2022 Background Well-balanced interactions between gut microbiota and the immune system are essential to prevent chronic intestinal inflammation, as observed in inflammatory bowel diseases (IBD). Toll-like receptor 4 (TLR4) functions as a sensor mediating the
Yaojiang Liu +12 more
semanticscholar +1 more source