Results 91 to 100 of about 175,490 (344)

Haptoglobin Acts as a TLR4 Ligand to Suppress Osteoclastogenesis via the TLR4–IFN-β Axis [PDF]

The Journal of Immunology, 2019
Abstract Haptoglobin (Hp), a type of acute-phase protein, is known to have a systemic anti-inflammatory function and to modulate inflammation by directly affecting immune cells, such as T cells, dendritic cells, and macrophages. However, the effects of Hp on osteoclast differentiation are not well studied, even though osteoclast ...
Jun-Oh Kwon, Won Jong Jin, Bongjun Kim, Hyunil Ha, Hong-Hee Kim, Zang Hee Lee   +5 more
openaire   +3 more sources

A Novel Core–Shell Hydrogel 3D Model for Studying Macrophage Mechanosensing and Foreign Body Giant Cell Formation

Advanced Healthcare Materials, EarlyView.
The foreign body response (FBR) to biomaterials is primarily driven by macrophages, which often fuse into destructive foreign body giant cells (FBGCs). To address the limited understanding of FBGC formation, a novel microscale core–shell hydrogel 3D model is developed using heterogeneous alginate‐collagen microcapsules with varying stiffness, offering ...
Manisha Mahanty, Wenquan Ou, Xiaoping Zhu, Jonathan S Bromberg, Xiaoming He, Shaik O. Rahaman   +5 more
wiley   +1 more source

Effects of Dendrobium huoshanense polysaccharides on antioxidant capacity, mucosal barrier integrity and inflammatory responses in an aging rat ileal model

Biotechnology & Biotechnological Equipment, 2019
Polysaccharides are important pharmacologically active substances found in the perennial orchid Dendrobium huoshanense. In the present study, we sought to determine whether antioxidant and anti-inflammatory mechanisms were involved in Dendrobium ...
Hai-Jun Xu, Xue-Lian Hao, De-Liang Qiao, Lun-Bing Xia, Rui Chen, Xiao-Mei He, Fang-Li Gu, Chuan-Bao Wei   +7 more
doaj   +1 more source

ROS‐Scavenging Multifunctional Microneedle Patch Facilitating Wound Healing

Advanced Healthcare Materials, EarlyView.
A reactive oxygen species (ROS) scavenging and immunomodulatory microneedle patch based on hyaluronic acid methacrylate (HaMA) and Flightless I (Flii)‐siRNA‐laden arginine functionalized poly (β‐amino ester)/alginate particles is developed for chronic wound healing applications.
Mahshid Kharaziha, Sahar Salehi, Mahshid Shokri, Seyed Mohsen Ahmadi Tafti, Thomas Scheibel   +4 more
wiley   +1 more source

Associations of CYLD, JAK2 and TLR4 Genotypes with PSA Levels and Immunophenotype in Benign Prostatic Hyperplasia and Prostate Cancer

Frontiers in Bioscience-Landmark
Background: Prostate cancer (PCa) is one of the most common malignant tumors of the male urinary system, and its incidence and mortality rates have been increasing worldwide.
Le Vu Duy, Pham Thi Huong, Nguyen Trung Nam, Do Thi Trang, Nghiem Thi Minh Chau, Tran Thi Phuong Thao, Nguyen Huy Hoang, Nguyen Thien Tao, Can Van Mao, Nguyen Thi Xuan   +9 more
doaj   +1 more source

Linarin Protects Against CCl4-Induced Acute Liver Injury via Activating Autophagy and Inhibiting the Inflammatory Response: Involving the TLR4/MAPK/Nrf2 Pathway

Drug Design, Development and Therapy, 2023
Lulu Li,1,2 Yan Lan,3 Fuqian Wang,1,2 Tiexiang Gao1 1Faculty of Pharmacy, Hubei University of Chinese Medicine, Wuhan, Hubei, People’s Republic of China; 2Department of Pharmacy, Wuhan NO.1 Hospital, Wuhan, Hubei, People’s Republic of China; 3Department ...
Li L, Lan Y, Wang F, Gao T
doaj  

Mesoporous Bioactive Glasses: A Powerful Tool in Tissue Engineering and Drug Delivery

Advanced Healthcare Materials, EarlyView.
This work is a comprehensive revision of bioactive glasses (BGs), pioneered by Prof. L.L. Hench, which are key in bone repair and regenerative medicine. Sol–gel methods and mesoporous designs enhanced their bioactivity, ions, and drug delivery. BGs now support gene therapy and 3D‐printed scaffolds, enabling personalized, multifunctional treatments in ...
Natividad Gómez‐Cerezo, Daniel Lozano, Antonio J. Salinas, María Vallet‐Regí   +3 more
wiley   +1 more source

Role of TLR4 (Toll-Like Receptor 4) in N1/N2 Neutrophil Programming After Stroke.

Stroke, 2019
Background and Purpose- After stroke, the population of infiltrated neutrophils in the brain is heterogeneous, including a population of alternative neutrophils (N2) that express M2 phenotype markers.
A. García-Culebras, V. Durán-Laforet, C. Peña-Martinez, A. Moraga, I. Ballesteros, M. I. Cuartero, Juan de la Parra, S. Palma-Tortosa, A. Hidalgo, Á. Corbí, M. Moro, I. Lizasoaín   +11 more
semanticscholar   +1 more source

TLR4 as a negative regulator of keratinocyte proliferation

PLOS ONE, 2017
TLR4 is an innate immune receptor with expression in human skin, keratinocytes as well as squamous cell carcinoma (SCC) of the skin. In the present study we investigate the role of TLR4 as a negative regulator of keratinocyte proliferation. We present here that the expression of TLR4 increased with the differentiation of cultured keratinocytes in a ...
Iotzova-Weiss, Guergana, Freiberger, Sandra N, Johansen, Pål, Kamarachev, Jivko, Guenova, Emmanuella, Dziunycz, Piotr J, Roux, Guillaume A, Neu, Johannes, Hofbauer, Günther F L   +8 more
openaire   +6 more sources

A Peptide Antagonist of the TLR4–MD2 Interaction [PDF]

ChemBioChem, 2009
AbstractToll‐like receptors are an integral part of innate immunity in the central nervous system (CNS); they orchestrate a robust defense in response to both exogenous and endogenous danger signals. Recently, toll‐like receptor 4 (TLR4) has emerged as a therapeutic target for the treatment of CNS‐related diseases such as sepsis and chronic pain.
Slivka, P., Shridhar, M., Lee, G., Sammond, D., Hutchinson, M., Martinko, A., Buchanan, M., Sholar, P., Kearney, J., Harrison, J., Watkins, L., Yin, H.   +11 more
openaire   +3 more sources