Results 91 to 100 of about 237,895 (332)

Characterization of structural and immunological properties of a fusion protein between flagellin from Salmonella and lumazine synthase from Brucella [PDF]

, 2017
Aiming to combine the flexibility of Brucella lumazine synthase (BLS) to adapt different protein domains in a decameric structure and the capacity of BLS and flagellin to enhance the immunogenicity of peptides that are linked to their structure, we ...
Berguer, Paula Mercedes, Biedma, Marina Elizabeth, Blancá, Bruno Martin, Cayet, D., Errea, Agustina Juliana, Goldbaum, Fernando Alberto, Hiriart, Yanina, Moreno, Griselda Noemí, Rinaldi, Jimena Julieta, Rossi, Andrés Hugo, Rumbo, Martín, Sirard, J.C.   +11 more
core   +3 more sources

TRIM38 Suppresses Breast Cancer Progression via Modulating SQSTM1 Ubiquitination and Autophagic Flux

Advanced Science, EarlyView.
TRIM38, an E3 ubiquitin ligase, suppresses breast cancer progression by inhibiting proliferation, migration, and invasion. Downregulated in breast tumor, its loss correlates with poor prognosis. Mechanistically, TRIM38 mediates K63‐linked ubiquitination of SQSTM1/p62 at K420, disrupting SQSTM1‐LC3 interaction and blocking autophagic flux.
Shan Jiang, Lijuan Wang, Dianwen Han, Peng Su, Bing Chen, Wenjing Zhao, Tong Chen, Ning Zhang, Xiaolong Wang, Yiran Liang, Yaming Li, Chen Li, Xi Chen, Dan Luo, Qifeng Yang   +14 more
wiley   +1 more source

LPS-induced Pellino3 degradation is mediated by p62-dependent autophagy [PDF]

, 2012
Background: In macrophages Toll-like receptor 4 (TLR4) is activated in response to lipopolysaccharide (LPS) and induces proinflammatory cytokine expression. Therefore, mechanisms terminating proinflammatory gene expression are important.
Brüne, Bernhard, Eifler, Lisa, Heeg, Annika, Heide, Hermann, Knape, Tilo, Knethen, Andreas von, Kuchler, Laura   +6 more
core   +1 more source

Fermented Lacticaseibacillus Paracasei Cultures Ameliorate Colitis by Modulating Microbiota‐Derived Tryptophan Metabolism and Macrophage Polarization

Advanced Science, EarlyView.
A solid‐state fermented probiotic (PYW) is developed using wheat bran as substrate, containing high viable Lacticaseibacillus paracasei and bioactive metabolites. PYW alleviates intestinal inflammation by gut microbiota composition, enriching indole derivatives, activating aryl hydrocarbon receptor signaling, and regulating macrophage polarization. PYW
Heng Zhang, Jingzhou Sun, Xin Zheng, Huiqing Yang, Aowen Xie, Yuxuan Ding, Yuxia Mei, Jinshan Li, Yuanliang Hu, Min Ren, Yangyang Liu, Yunxiang Liang   +11 more
wiley   +1 more source

TAK-242 alleviates diabetic cardiomyopathy via inhibiting pyroptosis and TLR4/CaMKII/NLRP3 pathway

Open Life Sciences
Diabetic cardiomyopathy (DCM) is identified as a progressive disease that may lead to irreparable heart failure. Toll-like receptor (TLR) signaling is believed to be implicated in the pathogenesis of DCM.
Zhao Xiaolong, Zhang Jing, Xu Feng, Shang Longqi, Liu Qingquan, Shen Chunjian   +5 more
doaj   +1 more source

Liver X Receptors Activation Attenuates Ischemia Reperfusion Injury of Liver Graft in Rats

Journal of Investigative Surgery, 2019
Purpose: Suppression of the Toll like receptor 4 (TLR4)-nuclear factor-κB (NF-κB) signaling was critical in protection against liver IRI. Previous studies revealed that Liver X receptors (LXRs) activation could antagonize TLR4-NF-κB signaling.
Ming-xiang Cheng, Ping Huang, Qiang He, Yong Chen, Jin-zheng Li   +4 more
doaj   +1 more source

TLR4 knockdown by miRNA-140-5p improves tendinopathy: an in vitr o study

Archives of Medical Science, 2020
Introduction The purpose of this study was to determine whether TLR4 knockdown induced by miRNA-140-5p improves tendinopathy in an in vitro experiment. Material and methods Extraction of tendon-derived stem cells (TDSCs) from SD rats was performed using
Tu Jun, Guo Ruipeng, Xu Bin
doaj   +1 more source

Nucleosomes and neutrophil extracellular traps in septic and burn patients [PDF]

, 2017
NETosis is a host defense mechanism associated with inflammation and tissue damage. Experimental models show that platelets and von Willebrand factor (VWF) are key elements for intravascular NETosis. We determined NETosis in septic and burn patients at 1
Carestia, Agostina, D'Atri, Lina Paola, Fandiño, María Eugenia, Fondevila, Carlos, Guzman, María Alejandra, Kaufman, Tomás, Magosevich, Débora, Moreno, María Carolina, Schattner, Mirta Ana   +8 more
core   +1 more source

Increased Blood Flow and Tendon Swelling Precedes Vascular Expansion and Tissue Matrix Changes In Early Human Tendinopathy: A Potential Window for Superior Treatment Response

Advanced Science, EarlyView.
Human participants with early‐ or chronic‐stage tendinopathy and healthy controls are investigated using ultrasound Doppler, 3T and 7T MRI, and tendon biopsies. Tendon swelling and hyperperfusion are evident early, while vascular growth and extracellular matrix changes are most pronounced in chronic tendinopathy. Early intervention may provide superior
Max F. R. Merkel, Nikolaj M. Malmgaard‐Clausen, Marius Lendal, Hartwig R. Siebner, René B. Svensson, Stephanie G. Dakin, Marcus Krüger, Luisa Schmidt, Jakob Agergaard, Ching‐Yan Chloé Yeung, S. Peter Magnusson, Michael Kjaer   +11 more
wiley   +1 more source

EXPRESSION FEATURES OF TOLL-LIKE RECEPTOR 2 AND TOLL-LIKE RECEPTOR 4 IN CHILDREN WITH ASTHMA

Медицинская иммунология, 2017
Currently actively  discussed  the  role  of innate immunity receptors, in particular TLRs  in the immunopathogenesis of bronchial asthma (BA).The aim of our work was to study the expression of ТLR2 and TLR4 on the nasal mucosal cells and peripheral ...
L. V. Gankovskaya, L. S. Namazova-Baranova, M. V. Khoreva, B. G. Bragvadze, A. D. Ogurtsova, A. A. Alekseeva, V. А. Gankovskii, O. А. Svitich   +7 more
doaj   +1 more source