Results 11 to 20 of about 274,305 (384)

TLR4: the fall guy in sepsis? [PDF]

Cell Stress, 2020
Sepsis and its impact on human health can be traced back to 1000 BC and continues to be a major health burden today. It causes about 11 million deaths world-wide of which, more than a third are due to neonatal sepsis.
Joseph Menassa, Christina Nedeva, Corey Pollock, Hamsa Puthalakath   +3 more
doaj   +3 more sources

TLR4 endocytosis and endosomal TLR4 signaling are distinct and independent outcomes of TLR4 activation

EMBO Reports
Abstract Toll-like receptor 4 (TLR4) signaling at the plasma membrane and in endosomes results in distinct contributions to inflammation and host defence. Current understanding indicates that endocytosis of cell surface-activated TLR4 is required to enable subsequent signaling from endosomes.
Thomas E Schultz, Carmen D Mathmann, Leslie C Domínguez Cadena, Timothy W. Muusse, Hyoyoung Kim, James W. Wells, Glen C. Ulett, Jessica A. Hamerman, Andrew J. Brooks, Boštjan Kobe, Matthew J. Sweet, Katryn J. Stacey, Antje Blumenthal   +12 more
openalex   +3 more sources

Polymorphism study of TLR4 gene in crossbred cattle of Kerala [PDF]

Journal of Veterinary and Animal Sciences, 2023
The present study was conducted to identify single nucleotide variations in exon 3 region of the bovine Toll-Like Receptor gene (TLR4) associated with somatic cell score (SCS) in crossbred cattle of Kerala using polymerase chain reaction-single ...
G. Chishi Kiyevi, Valsalan Jamuna , Sadan Tina, K. Anilkumar, T. V. Aravindakshan, K. Radha   +5 more
doaj   +1 more source

Evaluation of the therapeutic potential of ant-TLR4-antibody MTS510 in experimental stroke and significa of different routes of application [PDF]

, 2016
Toll-like receptors (TLRs) are central sensors for the inflammatory response in ischemia-reperfusion injury. We therefore investigated whether TLR4 inhibition could be used to treat stroke in a standard model of focal cerebral ischemia.
Andresen, L., Czech-Zechmeister, B., Grünewald, S., Könnecke, B., Lühder, F., Theodorou, K., Trendelenburg, G.   +6 more
core   +17 more sources

Effects of Escherichia coli lipopolysaccharide on innate immunity: The expression profile of TLR4 and CD14 genes in rat's liver [PDF]

Open Veterinary Journal, 2021
Background: Bacterial Endotoxin (lipopolysaccharide) is essential for bacterial virulence, as it has a biphasic effect which is either harmful and leads to aseptic shock and death or assists the body defense mechanisms as it stimulates B-cells activation.
Ammar M. Al-Aalim, Ali A. Al-iedani, Mohammad A. Hamad   +2 more
doaj   +1 more source

Inflammatory signaling of HMGB1 in depressive disorder

Stress and Brain, 2023
Background:Depressive disorder is a common disease characterized by depressed mood and loss of pleasure, which often brings a great grief to patients and a huge burden to the society.
Qian Jiang, Chaoran Li, Huijing Xu, Taosheng Liu, Yunxia Wang   +4 more
doaj   +1 more source

Toll-like receptor 4 (TLR4): new insight immune and aging

Immunity & Ageing, 2023
TLR4, a transmembrane receptor, plays a central role in the innate immune response. TLR4 not only engages with exogenous ligands at the cellular membrane’s surface but also interacts with intracellular ligands, initiating intricate intracellular ...
Hyo-Jin Kim, Hyemin Kim, Jeong-Hyung Lee, C. Hwangbo   +3 more
semanticscholar   +1 more source

COVID-19 and Toll-Like Receptor 4 (TLR4): SARS-CoV-2 May Bind and Activate TLR4 to Increase ACE2 Expression, Facilitating Entry and Causing Hyperinflammation

Mediators of Inflammation, 2021
Causes of mortality from COVID‐19 include respiratory failure, heart failure, and sepsis/multiorgan failure. TLR4 is an innate immune receptor on the cell surface that recognizes pathogen‐associated molecular patterns (PAMPs) including viral proteins and
Mohamed M. Aboudounya, R. Heads
semanticscholar   +1 more source

TLR4 regulates RORγt+ regulatory T-cell responses and susceptibility to colon inflammation through interaction with Akkermansia muciniphila

Microbiome, 2022
Background Well-balanced interactions between gut microbiota and the immune system are essential to prevent chronic intestinal inflammation, as observed in inflammatory bowel diseases (IBD). Toll-like receptor 4 (TLR4) functions as a sensor mediating the
Yaojiang Liu, Min Yang, Li Tang, Fengchao Wang, Shengjie Huang, Shuang Liu, Yuanyuan Lei, Sumin Wang, Zhuo Xie, Wei Wang, Xiaoyan Zhao, Bo Tang, Shiming Yang   +12 more
semanticscholar   +1 more source

Reduction of endotoxicity in Bordetella bronchiseptica by lipid A engineering: Characterization of lpxL1 and pagP mutants

Virulence, 2021
Whole-cell vaccines against Gram-negative bacteria commonly display high reactogenicity caused by the endotoxic activity of lipopolysaccharide (LPS), one of the major components of the bacterial outer membrane. Underacylation of the lipid A moiety of LPS
Jesús Pérez-Ortega, Roel M. Van Harten, Ria Van Boxtel, Michel Plisnier, Marc Louckx, Dominique Ingels, Henk P. Haagsman, Jan Tommassen   +7 more
doaj   +1 more source