Results 11 to 20 of about 131,931 (297)

Polymorphisms of TLR4: Rapid Genotyping and Reduced Response to Lipopolysaccharide of TLR4 Mutant Alleles [PDF]

Clinical Chemistry, 2002
AbstractBackground: Pathogen recognition receptors such as Toll-like receptors (TLRs), which recognize pathogen-associated molecular patterns, lead to the activation of innate immunity. Genetic variations in these receptors may lead to an altered host immune response to pathogens.Methods: We developed homogeneous fluorescence-based PCR assays as well ...
Christopher A. Schmitt, Andreas Humeny, Cord‐Michael Becker, Kay Brune, Andreas Pahl   +4 more
openalex   +4 more sources

TLR4 and Insulin Resistance [PDF]

Gastroenterology Research and Practice, 2010
Chronic inflammation is a key feature of insulin resistance and obesity. Toll-Like Receptor 4 (TLR4), involved in modulating innate immunity, is an important mediator of insulin resistance and its comorbidities. TLR4 contributes to the development of insulin resistance and inflammation through its activation by elevated exogenous ligands (e.g., dietary
Jane J. Kim, Dorothy D. Sears
openaire   +4 more sources

Association between TLR4 and PTEN Involved in LPS-TLR4 Signaling Response [PDF]

BioMed Research International, 2016
In this study, we explored the potential mechanisms of how PTEN regulating LPS induced TLR4 signaling pathway. The initial findings from ELISA demonstrate that PTEN influences TNF-αsecretion by its lipid phosphatase activity. Subsequently, western blot, immunoprecipitation assay, and immunofluorescence were performed to explore the activation process ...
Huahua Yin, Yan Tan, Xiaofeng Wu, Hong Yan, Feng Liu, Yuanzhang Yao, Jianxin Jiang, Qi Wan, Lei Li   +8 more
openaire   +3 more sources

Biallelic TLR4 deficiency in humans

Journal of Allergy and Clinical Immunology, 2023
Toll-like receptors (TLRs) mediate functions for host defense and inflammatory responses. TLR4 recognizes LPS, a component of gram-negative bacteria as well as host-derived endogenous ligands such as S100A8 and S100A9 proteins.We sought to report phenotype and cellular function of individuals with complete TLR4 deficiency.We performed genome sequencing
Melania Capitani, Ahmad A. Al-Shaibi, Sumeet Pandey, Lisa Gartner, Henry Taylor, Satanay Z. Hubrack, Nourhen Agrebi, Muneera Jassim Al-Mohannadi, Saad Al Kaabi, Thomas Vogl, Johannes Roth, Daniel Kotlarz, Christoph Klein, Adrian K. Charles, Vinayan Vijayakumar, Mohammed Yousuf Karim, Bruce George, Simon P. Travis, Mamoun Elawad, Bernice Lo, Holm H. Uhlig   +20 more
openaire   +3 more sources

Ursolic acid induces the production of IL6 and chemokines in both adipocytes and adipose tissue

Adipocyte, 2020
Adipose tissue inflammation plays an important role in the regulation of glucose and lipids metabolism. It is unknown whether Ursolic acid (UA) could regulate adipose tissue inflammation, though it can regulate inflammation in many other tissues. In this
Bin Feng, Yingguo Zhu, Lijun Yan, Hui Yan, Xiaohua Huang, Dandan Jiang, Zhen Li, Lun Hua, Yong Zhuo, Zhengfeng Fang, Lianqiang Che, Yan Lin, Shengyu Xu, Chao Huang, Yuanfeng Zou, Lixia Li, De Wu   +16 more
doaj   +1 more source

TLR4/MyD88/PI3K interactions regulate TLR4 signaling

Journal of Leukocyte Biology, 2009
AbstractTLRs activate immune responses by sensing microbial structures such as bacterial LPS, viral RNA, and endogenous “danger” molecules released by damaged host cells. MyD88 is an adapter protein that mediates signal transduction for most TLRs and leads to activation of NF-κB and MAPKs and production of proinflammatory cytokines.
Matthew J. Fenton, Michelle H. W. Laird, Stefanie N. Vogel, Darren J. Perkins, Wenji Piao, Sang Hoon Rhee, Andrei E. Medvedev   +6 more
openaire   +4 more sources

Decursin negatively regulates LPS-induced upregulation of the TLR4 and JNK signaling stimulated by the expression of PRP4 in vitro

Animal Cells and Systems, 2020
The current investigation was carried out to analyze the correlation of bacterial lipopolysaccharide (LPS) and pre-mRNA processing factor 4B (PRP4) in inducing inflammatory response and cell actin cytoskeleton rearrangement in macrophages (Raw 264.7) and
Muhammad Bilal Ahmed, Salman Ul Islam, Young Sup Lee   +2 more
doaj   +1 more source

PPAR γ/TLR4/TGF-β1 axis mediates the protection effect of erythropoietin on cyclosporin A-induced chronic nephropathy in rat

Renal Failure, 2020
Objective Nephrotoxicity is the main side effect of cyclosporine A and finding an effective combating method is urgent. The present study investigates the improving effect of erythropoietin (EPO) on cyclosporine A induce renal injury in rats and further ...
Bin Liu, Ping Tan
doaj   +1 more source

Targeting Toll-Like Receptor 4: a promising strategy to prevent type 1 diabetes occurrence or recurrence [PDF]

CellR4, 2020
TLR4 is a transmembrane receptor of the innate immune system that recognize LPS of gram-negative bacteria. Its stimulation induces pro-inflammatory responses and also modulates adaptive immunity.
M. Alibashe-Ahmed, T. Berney, L. Giovannoni, E. Berishvili   +3 more
doaj   +1 more source

Knockdown of circ_0003204 alleviates oxidative low-density lipoprotein-induced human umbilical vein endothelial cells injury: Circulating RNAs could explain atherosclerosis disease progression

Open Medicine, 2021
Atherosclerosis (AS) is a serious cardiovascular disease. Circular RNAs (circRNAs) play an important role in the progression of many diseases, including AS. However, the role of circ_0003204 in AS is not clear.
Su Qiuxia, Dong Xianhua, Tang Chonghui, Wei Xiaojie, Hao Youguo, Wu Jun   +5 more
doaj   +1 more source