Results 11 to 20 of about 175,490 (344)
Virulence, 2021 Whole-cell vaccines against Gram-negative bacteria commonly display high reactogenicity caused by the endotoxic activity of lipopolysaccharide (LPS), one of the major components of the bacterial outer membrane. Underacylation of the lipid A moiety of LPS
Jesús Pérez-Ortega +7 more
doaj +1 more source
International Journal of Molecular Sciences, 2022 TLR4/NF-κB is a key inflammatory signaling transduction pathway, closely involved in cell differentiation, proliferation, apoptosis, and pro-inflammatory response.
Caiyun Yu +3 more
semanticscholar +1 more source
Association between TLR4 and PTEN Involved in LPS-TLR4 Signaling Response [PDF]
BioMed Research International, 2016 In this study, we explored the potential mechanisms of how PTEN regulating LPS induced TLR4 signaling pathway. The initial findings from ELISA demonstrate that PTEN influences TNF-αsecretion by its lipid phosphatase activity. Subsequently, western blot, immunoprecipitation assay, and immunofluorescence were performed to explore the activation process ...
Huahua Yin +8 more
openaire +3 more sources
The Prophylactic Use of Bovine Colostrum in a Murine Model of TNBS-Induced Colitis
Animals, 2020 This study investigated the effects of a short-term administration of bovine colostrum (BC) in a TNBS model of induced colitis. Colitis was induced by TNBS treatment after seven days of BC (BC group, n = 12) or saline (control group, n = 12 ...
Laura Menchetti +13 more
doaj +1 more source
Nature Communications, 2021 TLR4 signaling plays key roles in the innate immune response to microbial infection. Innate immune cells encounter different mechanical cues in both health and disease to adapt their behaviors.
Jing Geng +15 more
semanticscholar +1 more source
Biallelic TLR4 deficiency in humans
Journal of Allergy and Clinical Immunology, 2023 Toll-like receptors (TLRs) mediate functions for host defense and inflammatory responses. TLR4 recognizes LPS, a component of gram-negative bacteria as well as host-derived endogenous ligands such as S100A8 and S100A9 proteins.We sought to report phenotype and cellular function of individuals with complete TLR4 deficiency.We performed genome sequencing
Melania Capitani +20 more
openaire +3 more sources
The role of Toll-like receptors in chemoradiotherapy-induced gastrointestinal mucositis
口腔疾病防治, 2021 Mucositis is a common gastrointestinal complication in cancer patients undergoing chemoradiotherapy, including oral mucositis and gastrointestinal mucositis, with clinical manifestations of oral ulcers, vomiting, diarrhea and pain that seriously reduce ...
JI Ling +3 more
doaj +1 more source
TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling
Cellular and Molecular Life Sciences, 2020 Toll-like receptor (TLR) 4 belongs to the TLR family of receptors inducing pro-inflammatory responses to invading pathogens. TLR4 is activated by lipopolysaccharide (LPS, endotoxin) of Gram-negative bacteria and sequentially triggers two signaling ...
A. Ciesielska +2 more
semanticscholar +1 more source
Pathogens, 2020 Bovine mastitis is the inflammatory reaction of the mammary gland and is commonly caused by bacterial infections in high-yielding dairy cows. The detailed investigation of the immunotranscriptomic response of bovine mammary epithelial (BME) cells to ...
Md. Aminul Islam +12 more
doaj +1 more source
Flower extract of Caragana sinica. ameliorates Dss-induced ulcerative colitis by affecting TLR4/NF-κB and TLR4/MAPK signaling pathway in a mouse model [PDF]
Iranian Journal of Basic Medical Sciences, 2021 Objective(s): This study aimed to find out the protective effects and preliminary mechanisms of the flower extract of Caragana sinica (FEC) on dextran sulfate sodium salt (DSS)-induced colitis.Materials and Methods: The ulcerative colitis models of mice ...
Ting Li +9 more
doaj +1 more source