Results 231 to 240 of about 237,895 (332)

Tlr4 Sinyal Yolağının Modellenmesi

, 2012
A principal challenge for the life sciences is to understand the organization and dynamics of those components that make up a living system. Understanding the systems of cellular processes is very similar to solving many body problems including complex interactions, in this case among a large number of genes, proteins and other molecules.
openaire   +1 more source

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

Immunomodulatory Effect of <i>Artemisia annua</i> L. Water Extract on Meat-Type Sheep via Activating TLR4/NF-κB Signaling Pathways. [PDF]

Animals (Basel)
Gang G, Gao R, Guo S, Xin Y, Jin X, Xing Y, Yan S, Xu Y, Shi B.   +8 more
europepmc   +1 more source

TLR4 in Atherogenesis

Journal of the American College of Cardiology, 2018
openaire   +1 more source

Mechanisms of spinal glial activation in chemotherapy‐induced peripheral neuropathy: Focus on microglia and astrocytes

Ibrain, EarlyView.
Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley   +1 more source

Toll-like receptor 4 inhibition sensitizes non-small cell lung cancer to radiotherapy. [PDF]

Cancer Biol Ther
Haroun R, Rutihinda C, Diallo AH, Ordonez JP, Nassri S, Shams A, Pacheco MFM, Saidi NE, Bouchard L, Turgeon GA, Gris D, Tai LH, Oweida AJ.   +12 more
europepmc   +1 more source

Pre‐diagnostic immunological markers of bacterial translocation and liver cancer risk: A nested case–control analysis of 12 prospective cohorts

International Journal of Cancer, EarlyView.
What's New? Disruption of the gut–liver axis has been suggested to play an important role in liver carcinogenesis. However, limited prospective research has explored associations between potentially harmful gut‐derived bacterial products and liver cancer risk.
Cody Z. Watling, Peter T. Campbell, Barry I. Graubard, Yanyu Wang, Andrew T. Gewirtz, Xuehong Zhang, Matthew J. Barnett, Julie E. Buring, Yu Chen, A. Heather Eliassen, J. Michael Gaziano, Jonathan N. Hofmann, Wen‐Yi Huang, Jae H. Kang, Jill Koshiol, Erikka Loftfield, I‐Min Lee, Steven C. Moore, Lorelei A. Mucci, Marian L. Neuhouser, Christina C. Newton, Mark P. Purdue, Howard D. Sesso, Martha Shrubsole, Rashmi Sinha, Lesley Tinker, Matthew Triplette, Caroline Y. Um, Kala Visvanathan, Eleanor L. Watts, Jean Wactawski‐Wende, Walter Willett, Fen Wu, Wei Zheng, Dinesh Barupal, Jessica L. Petrick, Katherine A. McGlynn   +36 more
wiley   +1 more source

Atractylenolide I alleviates the experimental allergic response in mice by suppressing TLR4/NF-kB/NLRP3 signalling

Open Life Sciences
Cai Weiran, Zhang Zhijun, Shi Chenyan, Sun Ru, Ju Han, Dong Xuelin, Teng Lei   +6 more
doaj   +1 more source

Targeting the TLR4 axis with microbiota-oriented interventions and innovations in diabetes therapy: a narrative review. [PDF]

Front Immunol
Nikolaidis CG, Gyriki D, Stavropoulou E, Karlafti E, Didangelos T, Tsigalou C, Thanopoulou A.   +6 more
europepmc   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source