Toll-Like Receptor 4 Modulates Small Intestine Neuromuscular Function through Nitrergic and Purinergic Pathways [PDF]
, 2017 Objective: Toll-like receptors (TLRs) play a pivotal role in the homeostatic microflora-host crosstalk. TLR4-mediated modulation of both motility and enteric neuronal survival has been reported mainly for colon with limited information on the role of ...
Cecilia Giulivi +12 more
core +3 more sources
Renal Failure, 2020 Objective Nephrotoxicity is the main side effect of cyclosporine A and finding an effective combating method is urgent. The present study investigates the improving effect of erythropoietin (EPO) on cyclosporine A induce renal injury in rats and further ...
Bin Liu, Ping Tan
doaj +1 more source
Genetic variation of TLR4 influences immunoendocrine stress response: an observational study in cardiac surgical patients [PDF]
, 2011 Introduction: Systemic inflammation (e.g. following surgery) involves Toll-like receptor (TLR) signaling and leads to an endocrine stress response. This study aims to investigate a possible influence of TLR2 and TLR4 single nucleotide polymorphisms (SNPs)
Boehm, Olaf +9 more
core +2 more sources
Endothelial toll-like receptor 4 maintains lung integrity via epigenetic suppression of p16INK4a. [PDF]
, 2019 We previously reported that the canonical innate immune receptor toll-like receptor 4 (TLR4) is critical in maintaining lung integrity. However, the molecular mechanisms via which TLR4 mediates its effect remained unclear.
Ardito, Taylor +10 more
core +1 more source
Morphine activates neuroinflammation in a manner parallel to endotoxin [PDF]
, 2012 Opioids create a neuroinflammatory response within the CNS, compromising opioid-induced analgesia and contributing to various unwanted actions. How this occurs is unknown but has been assumed to be via classic opioid receptors.
A. A. Somogyi +42 more
core +2 more sources
Biallelic TLR4 deficiency in humans
Journal of Allergy and Clinical Immunology, 2023 Toll-like receptors (TLRs) mediate functions for host defense and inflammatory responses. TLR4 recognizes LPS, a component of gram-negative bacteria as well as host-derived endogenous ligands such as S100A8 and S100A9 proteins.We sought to report phenotype and cellular function of individuals with complete TLR4 deficiency.We performed genome sequencing
Melania Capitani +20 more
openaire +3 more sources
Targeting Toll-Like Receptor 4: a promising strategy to prevent type 1 diabetes occurrence or recurrence [PDF]
CellR4, 2020 TLR4 is a transmembrane receptor of the innate immune system that recognize LPS of gram-negative bacteria. Its stimulation induces pro-inflammatory responses and also modulates adaptive immunity.
M. Alibashe-Ahmed +3 more
doaj +1 more source
Gene dynamics of toll-like receptor 4 through a population bottleneck in an insular population of water voles (Arvicola amphibius) [PDF]
, 2015 Acknowledgments We would like to thank all colleagues who have contributed to fieldwork and sampling during this study. We would especially like to thank Marius Wenzel and Sandra Telfer for collaboration with different aspects of the study, and Dave ...
Douglas, Alex +3 more
core +2 more sources
Electronegative LDL Promotes Inflammation and Triglyceride Accumulation in Macrophages
Cells, 2020 Electronegative low-density lipoprotein (LDL) (LDL(−)), a modified LDL that is present in blood and exerts atherogenic effects on endothelial cells and monocytes.
Núria Puig +7 more
doaj +1 more source
Loss of ATF3 exacerbates liver damage through the activation of mTOR/p70S6K/ HIF-1α signaling pathway in liver inflammatory injury. [PDF]
, 2018 Activating transcription factor 3 (ATF3) is a stress-induced transcription factor that plays important roles in regulating immune and metabolic homeostasis.
Jiang, Bin +9 more
core +2 more sources