Results 21 to 30 of about 175,490 (344)

Ursolic acid induces the production of IL6 and chemokines in both adipocytes and adipose tissue

Adipocyte, 2020
Adipose tissue inflammation plays an important role in the regulation of glucose and lipids metabolism. It is unknown whether Ursolic acid (UA) could regulate adipose tissue inflammation, though it can regulate inflammation in many other tissues. In this
Bin Feng, Yingguo Zhu, Lijun Yan, Hui Yan, Xiaohua Huang, Dandan Jiang, Zhen Li, Lun Hua, Yong Zhuo, Zhengfeng Fang, Lianqiang Che, Yan Lin, Shengyu Xu, Chao Huang, Yuanfeng Zou, Lixia Li, De Wu   +16 more
doaj   +1 more source

The Defensive Action of LYRM03 on LPS-Induced Acute Lung Injury by NF-κB/TLR4/NLRP3 Signals

Journal of Investigative Surgery, 2021
The aim of the current investigation was to study the role of 3-amino-2-hydroxy-4-phenyl-valyl-isoleucine (LYRM03) in lipopolysaccharide (LPS)-induced acute lung injury (ALI) and investigate its potential pathogenesis.
Bin Wang, Jiaoyue Wang, Daopeng Lu, Na Qi, Qin Liu   +4 more
doaj   +1 more source

Expression and polymorphism of lTLR4 receptors in pathogenesis of chronic obstructive pulmonary disease: a modern view

Медицинская иммунология, 2021
Chronic obstructive pulmonary disease (COPD) is a progressive disease characterized by irreversible or partially reversible obstruction of the bronchial tree. Currently, there are many proven links in the COPD etiopathogenesis, among which a pivotal role
V. A. Beloglazov, I. A. Yatskov, Rean Hayrievna Useinova   +2 more
doaj   +1 more source

TLR4/MyD88/PI3K interactions regulate TLR4 signaling

Journal of Leukocyte Biology, 2009
AbstractTLRs activate immune responses by sensing microbial structures such as bacterial LPS, viral RNA, and endogenous “danger” molecules released by damaged host cells. MyD88 is an adapter protein that mediates signal transduction for most TLRs and leads to activation of NF-κB and MAPKs and production of proinflammatory cytokines.
Matthew J. Fenton, Michelle H. W. Laird, Stefanie N. Vogel, Darren J. Perkins, Wenji Piao, Sang Hoon Rhee, Andrei E. Medvedev   +6 more
openaire   +4 more sources

Toll-like receptor 4 (TLR4) antagonists as potential therapeutics for intestinal inflammation

Indian Journal of Gastroenterology, 2021
Gastrointestinal inflammation is a hallmark of highly prevalent disorders, including cancer treatment–induced mucositis and ulcerative colitis. These disorders cause debilitating symptoms, have a significant impact on quality of life, and are poorly ...
Janine S. Y. Tam, J. Coller, P. Hughes, C. Prestidge, J. Bowen   +4 more
semanticscholar   +1 more source

Decursin negatively regulates LPS-induced upregulation of the TLR4 and JNK signaling stimulated by the expression of PRP4 in vitro

Animal Cells and Systems, 2020
The current investigation was carried out to analyze the correlation of bacterial lipopolysaccharide (LPS) and pre-mRNA processing factor 4B (PRP4) in inducing inflammatory response and cell actin cytoskeleton rearrangement in macrophages (Raw 264.7) and
Muhammad Bilal Ahmed, Salman Ul Islam, Young Sup Lee   +2 more
doaj   +1 more source

Impact of HMGB1, RAGE, and TLR4 in Alzheimer’s Disease (AD): From Risk Factors to Therapeutic Targeting

Cells, 2020
Alzheimer’s disease (AD) is a devastating neurodegenerative disorder and a leading cause of dementia, with accumulation of amyloid-beta (Aβ) and neurofibrillary tangles (NFTs) as defining pathological features. AD presents a serious global health concern
Y. Paudel, Efthalia Angelopoulou, C. Piperi, Iekhsan Othman, K. Aamir, M. Shaikh   +5 more
semanticscholar   +1 more source

PPAR γ/TLR4/TGF-β1 axis mediates the protection effect of erythropoietin on cyclosporin A-induced chronic nephropathy in rat

Renal Failure, 2020
Objective Nephrotoxicity is the main side effect of cyclosporine A and finding an effective combating method is urgent. The present study investigates the improving effect of erythropoietin (EPO) on cyclosporine A induce renal injury in rats and further ...
Bin Liu, Ping Tan
doaj   +1 more source

Toll-Like Receptor 4 (TLR4)/Opioid Receptor Pathway Crosstalk and Impact on Opioid Analgesia, Immune Function, and Gastrointestinal Motility

Frontiers in Immunology, 2020
Toll-like receptor 4 (TLR4) recognizes exogenous pathogen-associated molecular patterns (PAMPs) and endogenous danger-associated molecular patterns (DAMPs) and initiates the innate immune response.
Peng Zhang, Meirong Yang, Chunhua Chen, Liu Liu, Xinchuan Wei, Si Zeng   +5 more
semanticscholar   +1 more source

Identification of Yak’s TLR4 Alternative Spliceosomes and Bioinformatic Analysis of TLR4 Protein Structure and Function [PDF]

Animals, 2020
In this study, the yak’s TLR4 gene alternative spliceosomes were investigated using PCR amplification and cloning to improve disease-resistance in yak and promote efficient utilization of yak’s resources. qRT-PCR was used to determine the expression levels of two alternatively spliced transcripts of the TLR4 gene in seven distinct tissues.
Xingdong Wang, Jie Pei, Pengjia Bao, Chunnian Liang, Min Chu, Shaoke Guo, Ping Yan, Xian Guo   +7 more
openaire   +4 more sources