Results 21 to 30 of about 131,931 (297)
Postulates for validating TLR4 agonists [PDF]
European Journal of Immunology, 2015 TLRs play a central role in the innate immune response, recognizing a variety of molecular structures characteristic of pathogens. Although TLR4, together with its co‐receptor myeloid differentiation‐2 (MD‐2), recognize bacterial LPS and therefore Gram‐negative bacterial infections, it also plays a key role in many other pathophysiological processes ...
Mateja Manček-Keber, Roman Jerala
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Identification of Yak’s TLR4 Alternative Spliceosomes and Bioinformatic Analysis of TLR4 Protein Structure and Function [PDF]
Animals, 2020 In this study, the yak’s TLR4 gene alternative spliceosomes were investigated using PCR amplification and cloning to improve disease-resistance in yak and promote efficient utilization of yak’s resources. qRT-PCR was used to determine the expression levels of two alternatively spliced transcripts of the TLR4 gene in seven distinct tissues.
Xingdong Wang +7 more
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Open Life Sciences, 2022 We investigated the role of the interaction between the Notch and Toll-like receptor 4 (TLR4) pathways in septic myocardial injury. The sepsis model was induced in rats with lipopolysaccharide (LPS). Rats were divided into control, LPS, LPS + TAK242 ((6R)
Liu Ziyang +7 more
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Effect of Lipopolysaccharide from Rhodobacter sphaeroides on Inflammatory Pathway and Oxidative Stress in Renal Ischemia/Reperfusion Injury in Male Rats [PDF]
Archives of Razi Institute, 2021 Ischemia/reperfusion injury (IRI) is caused by a sudden temporary impairment of the blood flow to the particular organ. The IRI of the kidneys is one of the main causes of acute kidney injury.
M Aal-Aaboda, A. R Abu Raghif, N. R Hadi
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TLR4-Targeting Therapeutics: Structural Basis and Computer-Aided Drug Discovery Approaches
Molecules, 2020 The integration of computational techniques into drug development has led to a substantial increase in the knowledge of structural, chemical, and biological data.
Qurat ul Ain +2 more
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Interaction of Opioids with TLR4—Mechanisms and Ramifications [PDF]
Cancers, 2021 The innate immune receptor toll-like receptor 4 (TLR4) is known as a sensor for the gram-negative bacterial cell wall component lipopolysaccharide (LPS). TLR4 activation leads to a strong pro-inflammatory response in macrophages; however, it is also recognised to play a key role in cancer.
Mai Mahmoud Gabr +6 more
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مقایسه بیان ژن های لاکتوفرین و TLR4 در سلول های سوماتیک شیر گاو هلشتاین، بومی گیلان و آمیخته‌های حاصل از آنها [PDF]
تحقیقات تولیدات دامی, 2016 هدف تحقیق حاضر مقایسه بیان ژنهای لاکتوفرین و TLR4 در سلولهای سوماتیک شیر گاو و بررسی تفاوتهای ژنتیکی و آمیختهگری بر بیان ژنهای سیستم ایمنی و همچنین اثرات ورم پستان بر بیان ژنهای مذکور است.
پری ناز رضوانی +3 more
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TLR4 and HMGB1: partners in crime? [PDF]
Kidney International, 2011 Chen et al. confirmed the role of Toll-like receptor 4 (TLR4) in ischemic kidney injury using mice harboring spontaneous disabling mutations of the receptor and generated chimeras between TLR4-/- and TLR4+/+ mice. The major findings demonstrate the necessity of TLR4 in leukocytes, as well as in epithelial and endothelial cells, for the full-blown ...
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Diabetes, Metabolic Syndrome and Obesity, 2020 Zhaoping Wang,1 Xiaolin Ni,1,2 Li Zhang,1 Liang Sun,1 Xiaoquan Zhu,1 Qi Zhou,1 Ze Yang,1 Huiping Yuan1 1The MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, Beijing, People’s Republic of China; 2Graduate School of
Wang Z +7 more
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Drug Design, Development and Therapy, 2023 Mingsheng Lyu,1,2 Jingbo Qin,3 Shuaiyang Huang,2 Dongmei Shao,4 Guirui Huang,2 Fan Yang,5,6 Xuefeng Gong,7 Shiyu Zhang,2 Zhijie Zhang,2 Ji Wang,6 Hongsheng Cui2 1Center of Respiratory Disease, Dongzhimen Hospital, Beijing University of Chinese Medicine ...
Lyu M +10 more
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