Results 21 to 30 of about 274,305 (384)

TLR4 and Insulin Resistance [PDF]

Gastroenterology Research and Practice, 2010
Chronic inflammation is a key feature of insulin resistance and obesity. Toll-Like Receptor 4 (TLR4), involved in modulating innate immunity, is an important mediator of insulin resistance and its comorbidities. TLR4 contributes to the development of insulin resistance and inflammation through its activation by elevated exogenous ligands (e.g., dietary
Jane J. Kim, Dorothy D. Sears
openaire   +4 more sources

Pharmacological Effects of Polyphenol Phytochemicals on the Intestinal Inflammation via Targeting TLR4/NF-κB Signaling Pathway

International Journal of Molecular Sciences, 2022
TLR4/NF-κB is a key inflammatory signaling transduction pathway, closely involved in cell differentiation, proliferation, apoptosis, and pro-inflammatory response.
Caiyun Yu, D. Wang, Zaibin Yang, Tian Wang   +3 more
semanticscholar   +1 more source

The Prophylactic Use of Bovine Colostrum in a Murine Model of TNBS-Induced Colitis

Animals, 2020
This study investigated the effects of a short-term administration of bovine colostrum (BC) in a TNBS model of induced colitis. Colitis was induced by TNBS treatment after seven days of BC (BC group, n = 12) or saline (control group, n = 12 ...
Laura Menchetti, Giulio Curone, Iulia Elena Filipescu, Olimpia Barbato, Leonardo Leonardi, Gabriella Guelfi, Giovanna Traina, Patrizia Casagrande-Proietti, Federica Riva, Anna Beatrice Casano, Federica Piro, Daniele Vigo, Alda Quattrone, Gabriele Brecchia   +13 more
doaj   +1 more source

The role of Toll-like receptors in chemoradiotherapy-induced gastrointestinal mucositis

口腔疾病防治, 2021
Mucositis is a common gastrointestinal complication in cancer patients undergoing chemoradiotherapy, including oral mucositis and gastrointestinal mucositis, with clinical manifestations of oral ulcers, vomiting, diarrhea and pain that seriously reduce ...
JI Ling, WANG Jiahe, WANG Jiantao, Wang Yan   +3 more
doaj   +1 more source

TLR4 signalling via Piezo1 engages and enhances the macrophage mediated host response during bacterial infection

Nature Communications, 2021
TLR4 signaling plays key roles in the innate immune response to microbial infection. Innate immune cells encounter different mechanical cues in both health and disease to adapt their behaviors.
Jing Geng, Yiran Shi, Jinjia Zhang, Bingying Yang, Ping Wang, Weihong Yuan, Hao Zhao, Junhong Li, Funiu Qin, Lixin Hong, Changchuan Xie, Xianming Deng, Yujie Sun, Congying Wu, Lanfen Chen, Dawang Zhou   +15 more
semanticscholar   +1 more source

TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling

Cellular and Molecular Life Sciences, 2020
Toll-like receptor (TLR) 4 belongs to the TLR family of receptors inducing pro-inflammatory responses to invading pathogens. TLR4 is activated by lipopolysaccharide (LPS, endotoxin) of Gram-negative bacteria and sequentially triggers two signaling ...
A. Ciesielska, Marta Matyjek, K. Kwiatkowska   +2 more
semanticscholar   +1 more source

Transcriptome Analysis of The Inflammatory Responses of Bovine Mammary Epithelial Cells: Exploring Immunomodulatory Target Genes for Bovine Mastitis

Pathogens, 2020
Bovine mastitis is the inflammatory reaction of the mammary gland and is commonly caused by bacterial infections in high-yielding dairy cows. The detailed investigation of the immunotranscriptomic response of bovine mammary epithelial (BME) cells to ...
Md. Aminul Islam, Michihiro Takagi, Kohtaro Fukuyama, Ryoya Komatsu, Leonardo Albarracin, Tomonori Nochi, Yoshihito Suda, Wakako Ikeda-Ohtsubo, Victor Rutten, Willem van Eden, Julio Villena, Hisashi Aso, Haruki Kitazawa   +12 more
doaj   +1 more source

Ursolic acid induces the production of IL6 and chemokines in both adipocytes and adipose tissue

Adipocyte, 2020
Adipose tissue inflammation plays an important role in the regulation of glucose and lipids metabolism. It is unknown whether Ursolic acid (UA) could regulate adipose tissue inflammation, though it can regulate inflammation in many other tissues. In this
Bin Feng, Yingguo Zhu, Lijun Yan, Hui Yan, Xiaohua Huang, Dandan Jiang, Zhen Li, Lun Hua, Yong Zhuo, Zhengfeng Fang, Lianqiang Che, Yan Lin, Shengyu Xu, Chao Huang, Yuanfeng Zou, Lixia Li, De Wu   +16 more
doaj   +1 more source

Paroxetine effect on expression of TLR2 and TLR4 genes in PBMCs of mentally normal individuals [PDF]

مجله پزشکی دانشگاه علوم پزشکی تبریز, 2021
Background: Paroxetine is one of the well-known antidepressants. Recent studies have focused on paroxetine’s probable immuno-modulatory effects, since findings have indicated inflammation’s role in the pathophysiology of depression.
Fatemeh Ganjalishahi, Anahid Hemmatpur, Mahdi Dehghan manshadi, Hossein Hadi nedoushan, Alireza Karimollah   +4 more
doaj   +1 more source

Hypoxia Preconditioning Increases Survival and Decreases Expression of Toll-like Receptor 4 in Pulmonary Artery Endothelial Cells Exposed to Lipopolysaccharide [PDF]

, 2013
Pulmonary or systemic infections and hypoxemic respiratory failure are among the leading causes of admission to intensive care units, and these conditions frequently exist in sequence or in tandem.
Ali, Irshad, Audi, Said H., Densmore, John C., Husnain, Fouad, Jacobs, Elizabeth R., Konduri, G. Ganesh, Medhora, Meetha, Nanchal, Rahul   +7 more
core   +2 more sources