Results 31 to 40 of about 237,895 (332)
Targeting danger molecules in tendinopathy: the HMGB1/TLR4 axis [PDF]
, 2017 Objectives: To seek evidence of the danger molecule, high-mobility group protein B1 (HMGB1) expression in human tendinopathy and thereafter, to explore mechanisms where HMGB1 may regulate inflammatory mediators and matrix regulation in human tendinopathy.
Akbar, Moeed +10 more
core +1 more source
Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence [PDF]
, 2005 Viral immune evasion strategies target key aspects of the host antiviral response. Recently, it has been recognized that Toll-like receptors (TLRs) have a role in innate defense against viruses.
Bartlett, Nathan W +8 more
core +3 more sources
Postulates for validating TLR4 agonists [PDF]
European Journal of Immunology, 2015 TLRs play a central role in the innate immune response, recognizing a variety of molecular structures characteristic of pathogens. Although TLR4, together with its co‐receptor myeloid differentiation‐2 (MD‐2), recognize bacterial LPS and therefore Gram‐negative bacterial infections, it also plays a key role in many other pathophysiological processes ...
Mateja, Manček-Keber, Roman, Jerala
openaire +2 more sources
Ivermectin decreases inflammation and imiquimod–induced psoriasis-like skin lesions in rat via targeting TLR4 / p65 NF-κB [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): Psoriasis is a chronic skin disease that usually manifests as white and silver spots on the skin. Because of its anti-inflammatory properties, we investigated the effects of ivermectin (IVM) on imiquimod (IMQ)-induced psoriasis in rats ...
Tayebeh Noori +2 more
doaj +1 more source
Animal Cells and Systems, 2020 Indole-6-carboxaldehyde (I6CA), an indole derivative isolated from the marine brown algae Sargassum thunbergii, is known to have several beneficial effects, but no studies on immune regulation have been conducted.
Cheol Park +11 more
doaj +1 more source
TLR4-Targeting Therapeutics: Structural Basis and Computer-Aided Drug Discovery Approaches
Molecules, 2020 The integration of computational techniques into drug development has led to a substantial increase in the knowledge of structural, chemical, and biological data.
Qurat ul Ain +2 more
doaj +1 more source
Association between TLR4 and PTEN Involved in LPS-TLR4 Signaling Response
BioMed Research International, 2016 In this study, we explored the potential mechanisms of how PTEN regulating LPS induced TLR4 signaling pathway. The initial findings from ELISA demonstrate that PTEN influences TNF-αsecretion by its lipid phosphatase activity. Subsequently, western blot, immunoprecipitation assay, and immunofluorescence were performed to explore the activation process ...
Huahua Yin +8 more
openaire +3 more sources
TLR4 rs1927914 polymorphism contributes to serum TLR4 levels in patients with aortic aneurysm
Experimental and Molecular Pathology, 2021 Toll-like receptor 4 (TLR4) is a crucial regulator of inflammatory reactions and vascular remodeling. Elevated TLR4 expression has been proved to be correlated with an increased risk of aortic aneurysm (AA). This study aimed to explore the influence of TLR4 gene polymorphisms on TLR4 expression levels and its probable functional significance in AA ...
Tan, Li +5 more
openaire +2 more sources
Acta Biomedica Scientifica, 2023 The aim of the study. To identify the frequency of occurrence of TLR4 Asp299Gly (rs4986790) gene polymorphism and to establish its contribution to the development of organ dysfunction in patients with severe pneumonia associated with A/H1N1 influenza ...
A. V. Malyarchikov, K. G. Shapovalov
doaj +1 more source
Drug Design, Development and Therapy, 2023 Mingsheng Lyu,1,2 Jingbo Qin,3 Shuaiyang Huang,2 Dongmei Shao,4 Guirui Huang,2 Fan Yang,5,6 Xuefeng Gong,7 Shiyu Zhang,2 Zhijie Zhang,2 Ji Wang,6 Hongsheng Cui2 1Center of Respiratory Disease, Dongzhimen Hospital, Beijing University of Chinese Medicine ...
Lyu M +10 more
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