Results 31 to 40 of about 222,436 (284)

Postulates for validating TLR4 agonists [PDF]

European Journal of Immunology, 2015
TLRs play a central role in the innate immune response, recognizing a variety of molecular structures characteristic of pathogens. Although TLR4, together with its co‐receptor myeloid differentiation‐2 (MD‐2), recognize bacterial LPS and therefore Gram‐negative bacterial infections, it also plays a key role in many other pathophysiological processes ...
Mateja, Manček-Keber, Roman, Jerala
openaire   +2 more sources

Targeting danger molecules in tendinopathy: the HMGB1/TLR4 axis [PDF]

, 2017
Objectives: To seek evidence of the danger molecule, high-mobility group protein B1 (HMGB1) expression in human tendinopathy and thereafter, to explore mechanisms where HMGB1 may regulate inflammatory mediators and matrix regulation in human tendinopathy.
Akbar, Moeed, Crowe, Lindsay A.N., Garcia-Melchor, Emma, Gilchrist, Derek S., Kerr, Shauna C., Kitson, Susan M., McInnes, Iain B., Millar, Neal L., Murrell, George A.C., Nelis, Briana, Reilly, James H.   +10 more
core   +1 more source

Ivermectin decreases inflammation and imiquimod–induced psoriasis-like skin lesions in rat via targeting TLR4 / p65 NF-κB [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Psoriasis is a chronic skin disease that usually manifests as white and silver spots on the skin. Because of its anti-inflammatory properties, we investigated the effects of ivermectin (IVM) on imiquimod (IMQ)-induced psoriasis in rats ...
Tayebeh Noori, Antoni Sureda, Samira Shirooie   +2 more
doaj   +1 more source

TLR4 knockdown by miRNA-140-5p improves tendinopathy: an in vitr o study

Archives of Medical Science, 2020
Introduction The purpose of this study was to determine whether TLR4 knockdown induced by miRNA-140-5p improves tendinopathy in an in vitro experiment. Material and methods Extraction of tendon-derived stem cells (TDSCs) from SD rats was performed using
Tu Jun, Guo Ruipeng, Xu Bin
doaj   +1 more source

Association between TLR4 and PTEN Involved in LPS-TLR4 Signaling Response

BioMed Research International, 2016
In this study, we explored the potential mechanisms of how PTEN regulating LPS induced TLR4 signaling pathway. The initial findings from ELISA demonstrate that PTEN influences TNF-αsecretion by its lipid phosphatase activity. Subsequently, western blot, immunoprecipitation assay, and immunofluorescence were performed to explore the activation process ...
Huahua Yin, Yan Tan, Xiaofeng Wu, Hong Yan, Feng Liu, Yuanzhang Yao, Jianxin Jiang, Qi Wan, Lei Li   +8 more
openaire   +3 more sources

TLR4 rs1927914 polymorphism contributes to serum TLR4 levels in patients with aortic aneurysm

Experimental and Molecular Pathology, 2021
Toll-like receptor 4 (TLR4) is a crucial regulator of inflammatory reactions and vascular remodeling. Elevated TLR4 expression has been proved to be correlated with an increased risk of aortic aneurysm (AA). This study aimed to explore the influence of TLR4 gene polymorphisms on TLR4 expression levels and its probable functional significance in AA ...
Tan, Li, Jingjing, Jing, Nannan, Dong, Xiaozheng, Liu, Chunyan, Ma, Jun, Yang   +5 more
openaire   +2 more sources

Loss of ATF3 exacerbates liver damage through the activation of mTOR/p70S6K/ HIF-1α signaling pathway in liver inflammatory injury. [PDF]

, 2018
Activating transcription factor 3 (ATF3) is a stress-induced transcription factor that plays important roles in regulating immune and metabolic homeostasis.
Jiang, Bin, Jiang, Longfeng, Ke, Bibo, Li, Changyong, Lu, Ling, Ni, Xuhao, Wang, Han, Wang, Xuehao, Zhang, Feng, Zhu, Qiang   +9 more
core   +2 more sources

Bacterial TLR4 and NOD2 signaling linked to reduced mitochondrial energy function in active inflammatory bowel disease

Gut Microbes, 2020
Inflammatory bowel disease (IBD) has been linked to active signaling with bacterial components and reduced mitochondrial ATP production; however, synergism between both of these disease characteristics remains unclear.
Emmanuelle Ruiz, Harrison M. Penrose, Sandra Heller, Hani Nakhoul, Melody Baddoo, Erik F. Flemington, Emad Kandil, Suzana D. Savkovic   +7 more
doaj   +1 more source

TLR4 and NLRP3 Caspase 1- IL-1β- Axis are not Involved in Colon Ascendens Stent Peritonitis (Casp)-Associated Heart Disease [PDF]

, 2018
Hemodynamic collapse and myocardial dysfunction are among the major causes ofdeath in severe sepsis. The purpose of this study was to assess the role played by TLR4and by the NLRP3 inflammasome in the cardiac dysfunction that occurs after ...
Branda, Hugo Justino, Carvalho, Adriana Bastos, Fernandez Ruocco, Maria Julieta, Ferreira, Fabiano, López Alarcón, Maria Micaela, Medei, Emiliano, Neto Paiva, Claudia, Paula Neto, Heitor A., Peroba Ramos, Isalira, Sepúlveda, Marisa Noemí, Vila Petroff, Martin Gerarde   +10 more
core   +2 more sources

Tuo-Min-Ding-Chuan Decoction Alleviates Airway Inflammations in the Allergic Asthmatic Mice Model by Regulating TLR4-NLRP3 Pathway-Mediated Pyroptosis: A Network Pharmacology and Experimental Verification Study

Drug Design, Development and Therapy, 2023
Mingsheng Lyu,1,2 Jingbo Qin,3 Shuaiyang Huang,2 Dongmei Shao,4 Guirui Huang,2 Fan Yang,5,6 Xuefeng Gong,7 Shiyu Zhang,2 Zhijie Zhang,2 Ji Wang,6 Hongsheng Cui2 1Center of Respiratory Disease, Dongzhimen Hospital, Beijing University of Chinese Medicine ...
Lyu M, Qin J, Huang S, Shao D, Huang G, Yang F, Gong X, Zhang S, Zhang Z, Wang J, Cui H   +10 more
doaj