Results 31 to 40 of about 175,490 (344)
Ciprofloxacin and levofloxacin attenuate microglia inflammatory response via TLR4/NF-kB pathway
Journal of Neuroinflammation, 2019 Neuroinflammation is the response of the central nervous system to events that interfere with tissue homeostasis and represents a common denominator in virtually all neurological diseases.
M. Zusso +8 more
semanticscholar +1 more source
Frontiers in Neuroscience, 2020 Accumulating evidence has indicated that activation of microglia and neuroinflammation reaction play a prominent role in Alzheimer’s disease (AD). Inhibition of toll-like receptor 4 (TLR4) has been shown to be associated with immune responses and brain ...
Weigang Cui +5 more
semanticscholar +1 more source
Frontiers in Immunology, 2020 The innate immune response to lipopolysaccharide is essential for host defense against Gram-negative bacteria. In response to bacterial infection, the TLR4/MD-2 complex that is expressed on the surface of macrophages, monocytes, dendritic, and epithelial
A. Zamyatina, H. Heine
semanticscholar +1 more source
Effects of three types of fresh Rehmannia glutinosa improve lipopolysaccharide-induced acute kidney injury in sepsis through the estrogen receptor pathway [PDF]
Iranian Journal of Basic Medical Sciences, 2023 Objective(s): To explore the effects and mechanism of three types of fresh Rehmannia glutinosa, namely Beijing No. 3 (BJ3H), Huaizhong No. 1 (HZ1H), and Taisheng (TS) on lipopolysaccharide (LPS)-induced acute kidney injury in the sepsis (S-AKI) mice ...
Meng Liu +11 more
doaj +1 more source
Cell Death and Disease, 2020 Neuroinflammation plays a crucial role in the secondary phase of spinal cord injury (SCI), and is initiated following the activation of toll-like receptor 4 (TLR4). However, the downstream mechanism remains unknown.
Shun Xu +9 more
semanticscholar +1 more source
Postulates for validating TLR4 agonists [PDF]
European Journal of Immunology, 2015 TLRs play a central role in the innate immune response, recognizing a variety of molecular structures characteristic of pathogens. Although TLR4, together with its co‐receptor myeloid differentiation‐2 (MD‐2), recognize bacterial LPS and therefore Gram‐negative bacterial infections, it also plays a key role in many other pathophysiological processes ...
Mateja Manček-Keber, Roman Jerala
openaire +3 more sources
Interaction of Opioids with TLR4—Mechanisms and Ramifications [PDF]
Cancers, 2021 The innate immune receptor toll-like receptor 4 (TLR4) is known as a sensor for the gram-negative bacterial cell wall component lipopolysaccharide (LPS). TLR4 activation leads to a strong pro-inflammatory response in macrophages; however, it is also recognised to play a key role in cancer.
Mai Mahmoud Gabr +6 more
openaire +3 more sources
TLR4 and HMGB1: partners in crime? [PDF]
Kidney International, 2011 Chen et al. confirmed the role of Toll-like receptor 4 (TLR4) in ischemic kidney injury using mice harboring spontaneous disabling mutations of the receptor and generated chimeras between TLR4-/- and TLR4+/+ mice. The major findings demonstrate the necessity of TLR4 in leukocytes, as well as in epithelial and endothelial cells, for the full-blown ...
openaire +3 more sources
GINGIVAL FIBROBLAST MICROVESICLES MODULATE PRO-B CELLS APOPTOSIS IN SPECIFIC EXPERIMENTAL CONDITIONS
Romanian Journal of Oral Rehabilitation, 2023 Aim of the study The fast development of the tumor mass in acute lymphoblastic leukemia is dependent not only on the rate of cell proliferation, but also on the rate of apoptosis, with NR4A1 governing both tumor cell survival and death.
Carmen (Amititeloaie) Gentimir +3 more
doaj
Targeting Toll-Like Receptor 4: a promising strategy to prevent type 1 diabetes occurrence or recurrence [PDF]
CellR4, 2020 TLR4 is a transmembrane receptor of the innate immune system that recognize LPS of gram-negative bacteria. Its stimulation induces pro-inflammatory responses and also modulates adaptive immunity.
M. Alibashe-Ahmed +3 more
doaj +1 more source