Results 31 to 40 of about 131,931 (297)

TLR4 rs1927914 polymorphism contributes to serum TLR4 levels in patients with aortic aneurysm

Experimental and Molecular Pathology, 2021
Toll-like receptor 4 (TLR4) is a crucial regulator of inflammatory reactions and vascular remodeling. Elevated TLR4 expression has been proved to be correlated with an increased risk of aortic aneurysm (AA). This study aimed to explore the influence of TLR4 gene polymorphisms on TLR4 expression levels and its probable functional significance in AA ...
Chunyan Ma, Jingjing Jing, Nannan Dong, Jun Yang, Tan Li, Xiaozheng Liu   +5 more
openaire   +3 more sources

GINGIVAL FIBROBLAST MICROVESICLES MODULATE PRO-B CELLS APOPTOSIS IN SPECIFIC EXPERIMENTAL CONDITIONS

Romanian Journal of Oral Rehabilitation, 2023
Aim of the study The fast development of the tumor mass in acute lymphoblastic leukemia is dependent not only on the rate of cell proliferation, but also on the rate of apoptosis, with NR4A1 governing both tumor cell survival and death.
Carmen (Amititeloaie) Gentimir, Gabriela Geleţu, Andreea (Tibeică) Iordan, Marcel Costuleanu   +3 more
doaj  

The role of Toll-like receptor 4 gene polymorphism in the development of organ dysfunction in patients with severe pneumonia associated with A/H1N1 influenza

Acta Biomedica Scientifica, 2023
The aim of the study. To identify the frequency of occurrence of TLR4 Asp299Gly (rs4986790) gene polymorphism and to establish its contribution to the development of organ dysfunction in patients with severe pneumonia associated with A/H1N1 influenza ...
A. V. Malyarchikov, K. G. Shapovalov
doaj   +1 more source

TLR4 endocytosis and endosomal TLR4 signaling are distinct and independent outcomes of TLR4 activation

EMBO Reports
Abstract Toll-like receptor 4 (TLR4) signaling at the plasma membrane and in endosomes results in distinct contributions to inflammation and host defence. Current understanding indicates that endocytosis of cell surface-activated TLR4 is required to enable subsequent signaling from endosomes.
Thomas E Schultz, Carmen D Mathmann, Leslie C Domínguez Cadena, Timothy W Muusse, Hyoyoung Kim, James W Wells, Glen C Ulett, Jessica A Hamerman, Andrew J Brooks, Bostjan Kobe, Matthew J Sweet, Katryn J Stacey, Antje Blumenthal   +12 more
openaire   +2 more sources

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Ivermectin decreases inflammation and imiquimod–induced psoriasis-like skin lesions in rat via targeting TLR4 / p65 NF-κB [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Psoriasis is a chronic skin disease that usually manifests as white and silver spots on the skin. Because of its anti-inflammatory properties, we investigated the effects of ivermectin (IVM) on imiquimod (IMQ)-induced psoriasis in rats ...
Tayebeh Noori, Antoni Sureda, Samira Shirooie   +2 more
doaj   +1 more source

Expression and polymorphism of lTLR4 receptors in pathogenesis of chronic obstructive pulmonary disease: a modern view

Медицинская иммунология, 2021
Chronic obstructive pulmonary disease (COPD) is a progressive disease characterized by irreversible or partially reversible obstruction of the bronchial tree. Currently, there are many proven links in the COPD etiopathogenesis, among which a pivotal role
V. A. Beloglazov, I. A. Yatskov, Rean Hayrievna Useinova   +2 more
doaj   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Toll-like receptor 4 signaling-mediated responses are critically engaged in optimal host protection against highly virulent Mycobacterium tuberculosis K infection

Virulence, 2020
Toll-like receptors (TLRs) play critical roles in the innate recognition of Mycobacterium tuberculosis (Mtb) by host immune cells. However, controversy has arisen regarding the role of TLR4 in determining the outcomes of Mtb infection.
Jaehun Park, Hongmin Kim, Kee Woong Kwon, Hong-Hee Choi, Soon Myung Kang, Jung Joo Hong, Sung Jae Shin   +6 more
doaj   +1 more source

DOKing TLR4 signals

The Journal of Experimental Medicine, 2005
Two adaptor proteins prevent cells from overreacting to bacterial lipopolysaccaride (LPS), report Shinohara et al. on page 333. Dok-1 and Dok-2 dampen intracellular signals from the LPS receptor, Toll-like receptor 4 (TLR4), which may help explain how cells mount a potent response to invading bacteria without also triggering destructive inflammatory ...
openaire   +3 more sources