Results 41 to 50 of about 274,305 (384)

Toll-Like Receptor 4 (TLR4)/Opioid Receptor Pathway Crosstalk and Impact on Opioid Analgesia, Immune Function, and Gastrointestinal Motility

Frontiers in Immunology, 2020
Toll-like receptor 4 (TLR4) recognizes exogenous pathogen-associated molecular patterns (PAMPs) and endogenous danger-associated molecular patterns (DAMPs) and initiates the innate immune response.
Peng Zhang, Meirong Yang, Chunhua Chen, Liu Liu, Xinchuan Wei, Si Zeng   +5 more
semanticscholar   +1 more source

Morphine activates neuroinflammation in a manner parallel to endotoxin [PDF]

, 2012
Opioids create a neuroinflammatory response within the CNS, compromising opioid-induced analgesia and contributing to various unwanted actions. How this occurs is unknown but has been assumed to be via classic opioid receptors.
A. A. Somogyi, A. J. de Jesus, A. Reddy, Barochia, Bevan, Bokhari, Dziarski, H. Yin, Hargreaves, Hoshino, Hutchinson, Hutchinson, Hutchinson, Hutchinson, Hutchinson, Hutchinson, J. Thomas, Jacquet, Joce, K. Cheng, K. Ramos, Kirikae, L. C. Loram, L. R. Watkins, Lewis, Li, Liu, Liu, M. R. Hutchinson, Manavalan, Milligan, Nagyoszi, Narita, Ohto, Park, Resman, Rice, Slivka, Takeuchi, Viriyakosol, Watkins, X. Wang, Youn   +42 more
core   +2 more sources

Toll-like receptor 4 (TLR4) antagonists as potential therapeutics for intestinal inflammation

Indian Journal of Gastroenterology, 2021
Gastrointestinal inflammation is a hallmark of highly prevalent disorders, including cancer treatment–induced mucositis and ulcerative colitis. These disorders cause debilitating symptoms, have a significant impact on quality of life, and are poorly ...
Janine S. Y. Tam, J. Coller, P. Hughes, C. Prestidge, J. Bowen   +4 more
semanticscholar   +1 more source

Genetic variation of TLR4 influences immunoendocrine stress response: an observational study in cardiac surgical patients [PDF]

, 2011
Introduction: Systemic inflammation (e.g. following surgery) involves Toll-like receptor (TLR) signaling and leads to an endocrine stress response. This study aims to investigate a possible influence of TLR2 and TLR4 single nucleotide polymorphisms (SNPs)
Boehm, Olaf, Bornstein, Stefan R., Grotemeyer, Dirk, Hamann, Lutz, Koch, Alexander, Kurt, Muhammed, Schott, Matthias, Schumann, Ralf R., Schwenke, Carsten, Zacharowski, Kai   +9 more
core   +2 more sources

TLR4/MyD88/PI3K interactions regulate TLR4 signaling

Journal of Leukocyte Biology, 2009
AbstractTLRs activate immune responses by sensing microbial structures such as bacterial LPS, viral RNA, and endogenous “danger” molecules released by damaged host cells. MyD88 is an adapter protein that mediates signal transduction for most TLRs and leads to activation of NF-κB and MAPKs and production of proinflammatory cytokines.
Michelle H W, Laird, Sang Hoon, Rhee, Darren J, Perkins, Andrei E, Medvedev, Wenji, Piao, Matthew J, Fenton, Stefanie N, Vogel   +6 more
openaire   +3 more sources

Interaction of Opioids with TLR4—Mechanisms and Ramifications [PDF]

Cancers, 2021
The innate immune receptor toll-like receptor 4 (TLR4) is known as a sensor for the gram-negative bacterial cell wall component lipopolysaccharide (LPS). TLR4 activation leads to a strong pro-inflammatory response in macrophages; however, it is also recognised to play a key role in cancer.
Mai Mahmoud Gabr, Iqira Saeed, Jared A. Miles, Benjamin P. Ross, Paul Nicholas Shaw, Markus W. Hollmann, Marie-Odile Parat   +6 more
openaire   +3 more sources

Inflammatory response modulation by epinephrine and norepinephrine

RUDN Journal of Medicine, 2023
Relevance. Inflammation is a defense response of an organism to a pathogen. It appears in order to maintain homeostasis and is regulated by the immune, nervous, and endocrine systems.
Svetlana V. Guryanova, Artem S. Ferberg, Ilya A. Sigmatulin   +2 more
doaj   +1 more source

Endothelial toll-like receptor 4 maintains lung integrity via epigenetic suppression of p16INK4a. [PDF]

, 2019
We previously reported that the canonical innate immune receptor toll-like receptor 4 (TLR4) is critical in maintaining lung integrity. However, the molecular mechanisms via which TLR4 mediates its effect remained unclear.
Ardito, Taylor, Hwangbo, Cheol, Kim, So-Jin, Lee, Patty J, Li, Alfred, Min, Jin-Na, Peng, Tien, Sauler, Maor, Shan, Peiying, Zhang, Xuchen, Zhang, Yi   +10 more
core   +1 more source

Ciprofloxacin and levofloxacin attenuate microglia inflammatory response via TLR4/NF-kB pathway

Journal of Neuroinflammation, 2019
Neuroinflammation is the response of the central nervous system to events that interfere with tissue homeostasis and represents a common denominator in virtually all neurological diseases.
M. Zusso, Valentina Lunardi, D. Franceschini, A. Pagetta, R. Lo, S. Stifani, A. Frigo, P. Giusti, S. Moro   +8 more
semanticscholar   +1 more source

Inhibition of TLR4 Induces M2 Microglial Polarization and Provides Neuroprotection via the NLRP3 Inflammasome in Alzheimer’s Disease

Frontiers in Neuroscience, 2020
Accumulating evidence has indicated that activation of microglia and neuroinflammation reaction play a prominent role in Alzheimer’s disease (AD). Inhibition of toll-like receptor 4 (TLR4) has been shown to be associated with immune responses and brain ...
Weigang Cui, Chunli Sun, Yuqi Ma, Songtao Wang, Xianwei Wang, Yinghua Zhang   +5 more
semanticscholar   +1 more source