Results 41 to 50 of about 175,490 (344)
Electronegative LDL Promotes Inflammation and Triglyceride Accumulation in Macrophages
Cells, 2020 Electronegative low-density lipoprotein (LDL) (LDL(−)), a modified LDL that is present in blood and exerts atherogenic effects on endothelial cells and monocytes.
Núria Puig +7 more
doaj +1 more source
Oxidative Medicine and Cellular Longevity, 2020 Background It is widely accepted that inflammation may contribute to cognitive impairment in patients with vascular dementia (VD). Our prior clinical researches have reported that acupuncture can alleviate cognitive function in VD, but the underlying ...
Lu Wang +8 more
semanticscholar +1 more source
STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1β expression
Nature Communications, 2020 Detection of microbial components such as lipopolysaccharide (LPS) by Toll-like receptor 4 (TLR4) on macrophages induces a robust pro-inflammatory response that is dependent on metabolic reprogramming. These innate metabolic changes have been compared to
Jesse J. Balic +14 more
semanticscholar +1 more source
TLR4 Signaling Pathway Modulators as Potential Therapeutics in Inflammation and Sepsis
Vaccines, 2017 Toll-Like Receptor 4 (TLR4) signal pathway plays an important role in initiating the innate immune response and its activation by bacterial endotoxin is responsible for chronic and acute inflammatory disorders that are becoming more and more frequent in ...
N. Kuzmich +5 more
semanticscholar +1 more source
TLR4 rs1927914 polymorphism contributes to serum TLR4 levels in patients with aortic aneurysm
Experimental and Molecular Pathology, 2021 Toll-like receptor 4 (TLR4) is a crucial regulator of inflammatory reactions and vascular remodeling. Elevated TLR4 expression has been proved to be correlated with an increased risk of aortic aneurysm (AA). This study aimed to explore the influence of TLR4 gene polymorphisms on TLR4 expression levels and its probable functional significance in AA ...
Chunyan Ma +5 more
openaire +3 more sources
Ivermectin decreases inflammation and imiquimod–induced psoriasis-like skin lesions in rat via targeting TLR4 / p65 NF-κB [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): Psoriasis is a chronic skin disease that usually manifests as white and silver spots on the skin. Because of its anti-inflammatory properties, we investigated the effects of ivermectin (IVM) on imiquimod (IMQ)-induced psoriasis in rats ...
Tayebeh Noori +2 more
doaj +1 more source
Insight Into TLR4-Mediated Immunomodulation in Normal Pregnancy and Related Disorders
Frontiers in Immunology, 2020 Unlike organ transplants where an immunosuppressive environment is required, a successful pregnancy involves an extremely robust, dynamic, and responsive maternal immune system to maintain the development of the fetus.
P. Firmal +2 more
semanticscholar +1 more source
EMBO ReportsAbstract Toll-like receptor 4 (TLR4) signaling at the plasma membrane and in endosomes results in distinct contributions to inflammation and host defence. Current understanding indicates that endocytosis of cell surface-activated TLR4 is required to enable subsequent signaling from endosomes.
Thomas E Schultz +12 more
openaire +2 more sources
FEBS Letters, EarlyView.Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu +17 more
wiley +1 more source
Asian Pacific Journal of Tropical BiomedicineObjective: To evaluate the anti-inflammatory effect of black cumin seed oil (BCSO) and its nanoemulsion on lipopolysaccharide (LPS)-induced liver injury in mice. Methods: LPS-induced acute liver injury mouse model was used to evaluate the effects of BCSO
Hesham Haffez +3 more
doaj +1 more source