Results 51 to 60 of about 274,305 (384)
Frontiers in Immunology, 2020 The innate immune response to lipopolysaccharide is essential for host defense against Gram-negative bacteria. In response to bacterial infection, the TLR4/MD-2 complex that is expressed on the surface of macrophages, monocytes, dendritic, and epithelial
A. Zamyatina, H. Heine
semanticscholar +1 more source
The effect of a high-intensity interval training with Portulaca oleracea supplementation on Irisin and TLR4 in the liver tissue of rats with non-alcoholic fatty liver disease [PDF]
مجله علوم پزشکی فیض (پیوسته), 2023 Background: Lifestyle modification through dietary interventions and exercise training is still one of the most effective ways to treat non-alcoholic fatty liver disease.
Majid Farah Nia +3 more
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Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence [PDF]
, 2005 Viral immune evasion strategies target key aspects of the host antiviral response. Recently, it has been recognized that Toll-like receptors (TLRs) have a role in innate defense against viruses.
Bartlett, Nathan W +8 more
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Cell Death and Disease, 2020 Neuroinflammation plays a crucial role in the secondary phase of spinal cord injury (SCI), and is initiated following the activation of toll-like receptor 4 (TLR4). However, the downstream mechanism remains unknown.
Shun Xu +9 more
semanticscholar +1 more source
Targeting danger molecules in tendinopathy: the HMGB1/TLR4 axis [PDF]
, 2017 Objectives: To seek evidence of the danger molecule, high-mobility group protein B1 (HMGB1) expression in human tendinopathy and thereafter, to explore mechanisms where HMGB1 may regulate inflammatory mediators and matrix regulation in human tendinopathy.
Akbar, Moeed +10 more
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Oxidative Medicine and Cellular Longevity, 2020 Background It is widely accepted that inflammation may contribute to cognitive impairment in patients with vascular dementia (VD). Our prior clinical researches have reported that acupuncture can alleviate cognitive function in VD, but the underlying ...
Lu Wang +8 more
semanticscholar +1 more source
Postulates for validating TLR4 agonists [PDF]
European Journal of Immunology, 2015 TLRs play a central role in the innate immune response, recognizing a variety of molecular structures characteristic of pathogens. Although TLR4, together with its co‐receptor myeloid differentiation‐2 (MD‐2), recognize bacterial LPS and therefore Gram‐negative bacterial infections, it also plays a key role in many other pathophysiological processes ...
Mateja, Manček-Keber, Roman, Jerala
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TLR4 rs1927914 polymorphism contributes to serum TLR4 levels in patients with aortic aneurysm
Experimental and Molecular Pathology, 2021 Toll-like receptor 4 (TLR4) is a crucial regulator of inflammatory reactions and vascular remodeling. Elevated TLR4 expression has been proved to be correlated with an increased risk of aortic aneurysm (AA). This study aimed to explore the influence of TLR4 gene polymorphisms on TLR4 expression levels and its probable functional significance in AA ...
Tan, Li +5 more
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STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1β expression
Nature Communications, 2020 Detection of microbial components such as lipopolysaccharide (LPS) by Toll-like receptor 4 (TLR4) on macrophages induces a robust pro-inflammatory response that is dependent on metabolic reprogramming. These innate metabolic changes have been compared to
Jesse J. Balic +14 more
semanticscholar +1 more source
TLR4 knockdown by miRNA-140-5p improves tendinopathy: an in vitr o study
Archives of Medical Science, 2020 Introduction The purpose of this study was to determine whether TLR4 knockdown induced by miRNA-140-5p improves tendinopathy in an in vitro experiment. Material and methods Extraction of tendon-derived stem cells (TDSCs) from SD rats was performed using
Tu Jun, Guo Ruipeng, Xu Bin
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