Results 51 to 60 of about 262,575 (239)

Toll-Like Receptor 4 and Inflammatory Micro-Environment of Pancreatic Islets in Type-2 Diabetes Mellitus: A Therapeutic Perspective

open access: yesDiabetes, Metabolic Syndrome and Obesity, 2020
Zhaoping Wang,1 Xiaolin Ni,1,2 Li Zhang,1 Liang Sun,1 Xiaoquan Zhu,1 Qi Zhou,1 Ze Yang,1 Huiping Yuan1 1The MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, Beijing, People’s Republic of China; 2Graduate School of
Wang Z   +7 more
doaj  

Tuo-Min-Ding-Chuan Decoction Alleviates Airway Inflammations in the Allergic Asthmatic Mice Model by Regulating TLR4-NLRP3 Pathway-Mediated Pyroptosis: A Network Pharmacology and Experimental Verification Study

open access: yesDrug Design, Development and Therapy, 2023
Mingsheng Lyu,1,2 Jingbo Qin,3 Shuaiyang Huang,2 Dongmei Shao,4 Guirui Huang,2 Fan Yang,5,6 Xuefeng Gong,7 Shiyu Zhang,2 Zhijie Zhang,2 Ji Wang,6 Hongsheng Cui2 1Center of Respiratory Disease, Dongzhimen Hospital, Beijing University of Chinese Medicine ...
Lyu M   +10 more
doaj  

Silencing TLR4 using an ultrasound-targeted microbubble destruction-based shRNA system reduces ischemia-induced seizures in hyperglycemic rats

open access: yesOpen Life Sciences, 2022
The toll-like receptor 4 (TLR4) pathway is involved in seizures. We investigated whether ultrasound-targeted microbubble destruction (UTMD)-mediated delivery of short hairpin RNA (shRNA) targeting the TLR4 gene (shRNA-TLR4) can reduce ischemia-induced ...
Chen Jia   +4 more
doaj   +1 more source

TLR4 and NLRP3 Caspase 1- IL-1β- Axis are not Involved in Colon Ascendens Stent Peritonitis (Casp)-Associated Heart Disease [PDF]

open access: yes, 2018
Hemodynamic collapse and myocardial dysfunction are among the major causes ofdeath in severe sepsis. The purpose of this study was to assess the role played by TLR4and by the NLRP3 inflammasome in the cardiac dysfunction that occurs after ...
Branda, Hugo Justino   +10 more
core   +2 more sources

STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1β expression

open access: yesNature Communications, 2020
Detection of microbial components such as lipopolysaccharide (LPS) by Toll-like receptor 4 (TLR4) on macrophages induces a robust pro-inflammatory response that is dependent on metabolic reprogramming. These innate metabolic changes have been compared to
Jesse J. Balic   +14 more
semanticscholar   +1 more source

Toll-like receptor (TLR) 2 and TLR4 gene expression in canine heart [PDF]

open access: yes, 2007
Toll-like receptors (TLRs) are archetypal pattern recognition receptors of immediate importance for an efficacious innate immune response. TLRs exhibit marked differential tissue activity and their levels within a discrete cell type can be highly dynamic.
Blecha, Frank   +2 more
core   +2 more sources

TLR4 Signaling Pathway Modulators as Potential Therapeutics in Inflammation and Sepsis

open access: yesVaccines, 2017
Toll-Like Receptor 4 (TLR4) signal pathway plays an important role in initiating the innate immune response and its activation by bacterial endotoxin is responsible for chronic and acute inflammatory disorders that are becoming more and more frequent in ...
N. Kuzmich   +5 more
semanticscholar   +1 more source

Insight Into TLR4-Mediated Immunomodulation in Normal Pregnancy and Related Disorders

open access: yesFrontiers in Immunology, 2020
Unlike organ transplants where an immunosuppressive environment is required, a successful pregnancy involves an extremely robust, dynamic, and responsive maternal immune system to maintain the development of the fetus.
P. Firmal   +2 more
semanticscholar   +1 more source

GINGIVAL FIBROBLAST MICROVESICLES MODULATE PRO-B CELLS APOPTOSIS IN SPECIFIC EXPERIMENTAL CONDITIONS

open access: yesRomanian Journal of Oral Rehabilitation, 2023
Aim of the study The fast development of the tumor mass in acute lymphoblastic leukemia is dependent not only on the rate of cell proliferation, but also on the rate of apoptosis, with NR4A1 governing both tumor cell survival and death.
Carmen (Amititeloaie) Gentimir   +3 more
doaj  

Toll-like receptor-mediated signaling cascade as a regulator of the inflammation network during alcoholic liver disease [PDF]

open access: yes, 2014
Chronic abuse of alcohol leads to various histological abnormalities in the liver. These are conditions collectively known as alcoholic liver disease (ALD). Currently, ALD is considered to be one of the major causes of death worldwide.
Alisi, A., Ceccarelli, S, Nobili, V
core   +1 more source

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