Results 51 to 60 of about 175,490 (344)

Tuo-Min-Ding-Chuan Decoction Alleviates Airway Inflammations in the Allergic Asthmatic Mice Model by Regulating TLR4-NLRP3 Pathway-Mediated Pyroptosis: A Network Pharmacology and Experimental Verification Study

open access: yesDrug Design, Development and Therapy, 2023
Mingsheng Lyu,1,2 Jingbo Qin,3 Shuaiyang Huang,2 Dongmei Shao,4 Guirui Huang,2 Fan Yang,5,6 Xuefeng Gong,7 Shiyu Zhang,2 Zhijie Zhang,2 Ji Wang,6 Hongsheng Cui2 1Center of Respiratory Disease, Dongzhimen Hospital, Beijing University of Chinese Medicine ...
Lyu M   +10 more
doaj  

The immunostimulatory effect of indole-6-carboxaldehyde isolated from Sargassum thunbergii (Mertens) Kuntze in RAW 264.7 macrophages

open access: yesAnimal Cells and Systems, 2020
Indole-6-carboxaldehyde (I6CA), an indole derivative isolated from the marine brown algae Sargassum thunbergii, is known to have several beneficial effects, but no studies on immune regulation have been conducted.
Cheol Park   +11 more
doaj   +1 more source

TLR4-Targeting Therapeutics: Structural Basis and Computer-Aided Drug Discovery Approaches

open access: yesMolecules, 2020
The integration of computational techniques into drug development has led to a substantial increase in the knowledge of structural, chemical, and biological data.
Qurat ul Ain   +2 more
doaj   +1 more source

TLR4 signaling and macrophage inflammatory responses are dampened by GIV/Girdin

open access: yesProceedings of the National Academy of Sciences of the United States of America, 2020
Significance To ensure immunity, and yet limit pathology, inflammatory responses must be confined within the proverbial “Goldilocks zone.” TLR4 is the prototypical sensor that orchestrates inflammatory responses through a series of well-characterized ...
Lee Swanson   +12 more
semanticscholar   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

open access: yesFEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan   +2 more
wiley   +1 more source

EXPRESSION FEATURES OF TOLL-LIKE RECEPTOR 2 AND TOLL-LIKE RECEPTOR 4 IN CHILDREN WITH ASTHMA

open access: yesМедицинская иммунология, 2017
Currently actively  discussed  the  role  of innate immunity receptors, in particular TLRs  in the immunopathogenesis of bronchial asthma (BA).The aim of our work was to study the expression of ТLR2 and TLR4 on the nasal mucosal cells and peripheral ...
L. V. Gankovskaya   +7 more
doaj   +1 more source

Role of TLR4 in the gut-brain axis in Parkinson’s disease: a translational study from men to mice

open access: yesGut, 2018
Objective Recent evidence suggesting an important role of gut-derived inflammation in brain disorders has opened up new directions to explore the possible role of the gut-brain axis in neurodegenerative diseases.
P. Perez‐Pardo   +13 more
semanticscholar   +1 more source

Beta amyloid aggregates induce sensitised TLR4 signalling causing long-term potentiation deficit and rat neuronal cell death

open access: yesCommunications Biology, 2020
The molecular events causing memory loss and neuronal cell death in Alzheimer’s disease (AD) over time are still unknown. Here we found that picomolar concentrations of soluble oligomers of synthetic beta amyloid (Aβ42) aggregates incubated with BV2 ...
Craig D. Hughes   +9 more
semanticscholar   +1 more source

DOKing TLR4 signals

open access: yesThe Journal of Experimental Medicine, 2005
Two adaptor proteins prevent cells from overreacting to bacterial lipopolysaccaride (LPS), report Shinohara et al. on page 333. Dok-1 and Dok-2 dampen intracellular signals from the LPS receptor, Toll-like receptor 4 (TLR4), which may help explain how cells mount a potent response to invading bacteria without also triggering destructive inflammatory ...
openaire   +3 more sources

TLR2 and TLR4 in Ischemia Reperfusion Injury [PDF]

open access: yesMediators of Inflammation, 2010
Ischemia reperfusion (I/R) injury refers to the tissue damage which occurs when blood supply returns to tissue after a period of ischemia and is associated with trauma, stroke, myocardial infarction, and solid organ transplantation. Although the cause of this injury is multifactorial, increasing experimental evidence suggests an important role for the ...
A. E. Parker   +3 more
openaire   +4 more sources

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