Toll-like Receptor Expression Patterns in the Female Reproductive Tract of Sheep [PDF]
AnimalsToll-like receptors (TLRs) play crucial roles in innate immunity, but their function in reproduction remains poorly understood. This study investigated the expression patterns and localization of TLR1-9 in the reproductive system of Hu sheep and their ...
Zhibo Wang +8 more
doaj +2 more sources
Identification and experimental validation of biomarkers associated with macrophages in myocardial ischemia-reperfusion injury [PDF]
Scientific ReportsMyocardial ischemia-reperfusion injury (MIRI) is a complex process leading to substantial myocardial damage. Macrophages play a pivotal role in tissue development and homeostasis.
Xiaojie Jiang +3 more
doaj +2 more sources
The effect of combination therapy on Bevacizumab, Carmustine, and Metformin chemotherapy drugs on the fluctuating performance expression of TLR2, TLR6, and IL-6 genes in the cell line of brain glioblastoma [PDF]
Cancer Cell InternationalObjective Glioblastoma, one of the most aggressive brain tumors, is distinguished by its resistance to standard treatments. So, studying practical therapeutic methods is of great importance.
Seyedeh Elham Norollahi +10 more
doaj +2 more sources
Innate Immunity Toll‐Like Triad TLR6‐1‐10 and Its Diversity in Distinct Horse Breeds [PDF]
Veterinary Medicine and ScienceToll‐like receptors (TLRs) play important roles in innate immunity and developmental processes. Due to their nature as molecular pattern recognition receptors, their genetic diversity may reflect the effects of various pathogen pressures.
Karla Stejskalova +4 more
doaj +2 more sources
NFKB1 genetic variation and allergic rhinitis susceptibility: a study in the Chinese Han population [PDF]
Scientific ReportsAllergic rhinitis (AR), a highly prevalent inflammatory disorder of the upper respiratory tract, demonstrates strong genetic determinants. TLR6 and NFKB1 variants were genotyped to assess the associations with AR susceptibility. Blood samples from 992 AR
Haiying Wang +5 more
doaj +2 more sources
Hepatocyte Toll‐like receptors contribute to the hepcidin inflammatory response to pathogens and pathogen‐derived ligands [PDF]
HemaSphereIron restriction is a critical pathomechanism underlying the Anemia of Inflammation and an innate immune response limiting the replication of extracellular pathogens.
Katharina Bonitz +9 more
doaj +2 more sources
Current Oncology, 2023 Most so-called “beneficial bacteria” in gut microbiota are Gram-positive, and TLR6 recognizes the peptidoglycan (PGN) present in their cell walls. We hypothesized that a high TLR6 expression status predicts a more favorable prognosis after esophagectomy.
Yusuke Sato +12 more
doaj +1 more source
Activation of TLR2 and TLR6 by Dengue NS1 Protein and Its Implications in the Immunopathogenesis of Dengue Virus Infection. [PDF]
PLoS Pathogens, 2015 Dengue virus (DV) infection is the most prevalent mosquito-borne viral disease and its manifestation has been shown to be contributed in part by the host immune responses. In this study, pathogen recognition receptors, Toll-like receptor (TLR) 2 and TLR6
Jincheng Chen +2 more
doaj +1 more source
TLR1/TLR2 heterodimers play an important role in the recognition of Borrelia spirochetes. [PDF]
PLoS ONE, 2011 After infection with Borrelia species, the risk for developing Lyme disease varies significantly between individuals. Recognition of Borrelia by the immune system is mediated by pattern recognition receptors (PRRs), such as TLRs.
Marije Oosting +7 more
doaj +1 more source
HGG Advances, 2022 Summary: Human genetic diversity can have profound effects on health outcomes upon exposure to infectious agents. For infections with Chlamydia trachomatis (C.
Alyson B. Barnes +5 more
doaj +1 more source