Results 91 to 100 of about 16,414 (200)

Surface-Expressed TLR6 Participates in the Recognition of Diacylated Lipopeptide and Peptidoglycan in Human Cells [PDF]

The Journal of Immunology, 2005
Abstract Recognition of microbial components by TLR2 requires cooperation with other TLRs. TLR6 has been shown to be required for the recognition of diacylated lipoproteins and lipopeptides derived from mycoplasma and to activate the NF-κB signaling cascade in conjunction with TLR2.
Yoshiya, Nakao, Kenji, Funami, Satomi, Kikkawa, Mitsue, Taniguchi, Miyuki, Nishiguchi, Yasuhiro, Fukumori, Tsukasa, Seya, Misako, Matsumoto   +7 more
openaire   +2 more sources

Toll-like receptor gene polymorphisms are associated with allergic rhinitis: a case control study [PDF]

, 2012
10.1186/1471-2350-13-66BMC Medical Genetics13 ...
Andiappan, Anand Kumar, Cardell, Lars-Olaf, Halldén, Christer,, Lund University., Lund University., Nilsson, Daniel, Säll, Torbjörn,, Tim, Chew Fook, Yun, Wang De   +8 more
core   +3 more sources

Lung organoids as a human system for Mycobacteria infection modeling and drug testing

The FEBS Journal, Volume 293, Issue 6, Page 1587-1611, March 2026.
Mycobacterial infections, including tuberculosis (TB) and infections by nontuberculous mycobacteria (NTM), are still public health issues. In 2023, TB caused 1.25 million deaths, while NTM remain a clinical challenge for patients with cystic fibrosis (CF).
Stephen Adonai Leon‐Icaza, Romain Vergé, Raoul Mazars, Laurence Berry, Céline Cougoule   +4 more
wiley   +1 more source

Variants in toll-like receptor 9 gene influence susceptibility to tuberculosis in a Mexican population [PDF]

, 2013
Background: The control of Mycobacterium tuberculosis (Mtb) infection begins with the recognition of mycobacterial structural components by toll like receptors (TLRs) and other pattern recognition receptors.
Angeles, Javier, Baez-Saldaña, Renata, Barquera, Rodrigo, Campos, Lizeth, Carrera-Eusebio, Aida, Cruz-Lagunas, Alfredo, Fernández-Plata, Rosario, García-Sancho Figueroa, Ma Cecilia, Gopal, Radha, Granados, Julio, Khader, Shabaana A, Mendoza-Milla, Criselda, Ramírez-Bravo, Salomón, Torres-García, Diana, Vargas-Alarcón, Gilberto, Yunis, Edmond J, Zuñiga, Joaquin   +16 more
core   +1 more source

Comparative Transcriptomic Analysis of Human Macrophages During Mycobacterium avium Versus Mycobacterium tuberculosis Infection

Molecular Microbiology, Volume 125, Issue 3, Page 185-202, March 2026.
Human macrophage transcriptomic responses to Mycobacterium avium (Mav), a major cause of nontuberculous lung disease, were compared to Mycobacterium tuberculosis (Mtb). Both infections activated overlapping immune pathways, including cytokine signaling and GPCRs involved in lipid metabolism, while phospholipases were more strongly regulated by Mav and ...
Gül Kilinç, Robin H. G. A. van den Biggelaar, Tom H. M. Ottenhoff, Leon H. Mei, Anno Saris   +4 more
wiley   +1 more source

Wolbachia endosymbionts induce neutrophil extracellular trap formation in human onchocerciasis [PDF]

, 2016
The endosymbiotic bacteria, Wolbachia, induce neutrophilic responses to the human helminth pathogen Onchocerca volvulus. The formation of Neutrophil Extracellular Traps (NETs), has been implicated in anti-microbial defence, but has not been identified in
Edwards, SW, Guimaraes, AF, Johnston, KL, Midgley, A, Pionnier, N, Tamarozzi, F, Taylor, MJ, Turner, JD   +7 more
core   +3 more sources

Crosstalk Between Intratumoral Microbes and Tumor Immunity: Implications for Tumor Therapy

Cancer Medicine, Volume 15, Issue 2, February 2026.
ABSTRACT Background Emerging studies indicate that microbes are present in tumor cells and immune cells. Intratumoral microbiota (ITM) constitute an important component of the tumor immune microenvironment (TIME) and have an important impact on tumor progression and treatment. Objective Through the general elaboration of ITM represented by bacteria and
Fengxue Li, Lili Qiao, Xinquan Liang, Yingying Zhang, Ning Liang, Jian Xie, Guodong Deng, Yuying Hao, Pingping Hu, Xue Wu, Fangjie Ding, Can Feng, Yiming Mu, Jiandong Zhang   +13 more
wiley   +1 more source

Ureaplasma parvum lipoproteins, including MB antigen, activate NF-κB through TLR1, TLR2 and TLR6 [PDF]

Microbiology, 2008
Ureaplasma species (Ureaplasma parvum and Ureaplasma urealyticum) are commonly isolated pathogens from the female reproductive tract and are associated with perinatal diseases in humans. Inappropriate induction of inflammatory responses may be involved in the occurrence of such diseases; however, pathogenic agents that induce the inflammatory response ...
Takashi, Shimizu, Yutaka, Kida, Koichi, Kuwano   +2 more
openaire   +2 more sources

Genetic variation in TLR genes in Ugandan and South African populations and comparison with HapMap data.

PLoS ONE, 2012
Genetic epidemiological studies of complex diseases often rely on data from the International HapMap Consortium for identification of single nucleotide polymorphisms (SNPs), particularly those that tag haplotypes.
Allison R Baker, Feiyou Qiu, April Kaur Randhawa, David J Horne, Mark D Adams, Muki Shey, Jill Barnholtz-Sloan, Harriet Mayanja-Kizza, Gilla Kaplan, Willem A Hanekom, W Henry Boom, Thomas R Hawn, Catherine M Stein, Tuberculosis Research Unit and South African Tuberculosis Vaccine Initiative Team   +13 more
doaj   +1 more source

TLR-dependent control of Francisella tularensis infection and host inflammatory responses. [PDF]

PLoS ONE, 2009
BACKGROUND:Francisella tularensis is the causative agent of tularemia and is classified as a Category A select agent. Recent studies have implicated TLR2 as a critical element in the host protective response to F.
Allison L Abplanalp, Ian R Morris, Bijaya K Parida, Judy M Teale, Michael T Berton   +4 more
doaj   +1 more source